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Phyto-oestrogens and colorectal cancer risk: a systematic review and dose-response meta-analysis of observational studies

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Phyto-oestrogens and colorectal cancer risk: a systematic review and dose-response meta-analysis of observational studies. / Jiang, Ruijingfang; Botma, Akke; Rudolph, Anja; Hüsing, Anika; Chang-Claude, Jenny.

In: BRIT J NUTR, Vol. 116, No. 12, 12.2016, p. 2115-2128.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jiang, R, Botma, A, Rudolph, A, Hüsing, A & Chang-Claude, J 2016, 'Phyto-oestrogens and colorectal cancer risk: a systematic review and dose-response meta-analysis of observational studies', BRIT J NUTR, vol. 116, no. 12, pp. 2115-2128. https://doi.org/10.1017/S0007114516004360

APA

Jiang, R., Botma, A., Rudolph, A., Hüsing, A., & Chang-Claude, J. (2016). Phyto-oestrogens and colorectal cancer risk: a systematic review and dose-response meta-analysis of observational studies. BRIT J NUTR, 116(12), 2115-2128. https://doi.org/10.1017/S0007114516004360

Vancouver

Jiang R, Botma A, Rudolph A, Hüsing A, Chang-Claude J. Phyto-oestrogens and colorectal cancer risk: a systematic review and dose-response meta-analysis of observational studies. BRIT J NUTR. 2016 Dec;116(12):2115-2128. https://doi.org/10.1017/S0007114516004360

Bibtex

@article{42c3f674871b4aecb6cd63e5d0043ce2,
title = "Phyto-oestrogens and colorectal cancer risk: a systematic review and dose-response meta-analysis of observational studies",
abstract = "Epidemiological studies suggest that soya consumption as a source of phyto-oestrogens and isoflavones may be associated with a reduced risk of colorectal cancer. However, findings have not yet been synthesised for all groups of phyto-oestrogens. A meta-analysis was conducted to quantify the association between phyto-oestrogens and colorectal cancer risk. Relevant observational studies published up to June 2016 were identified by searching MEDLINE, EMBASE and Cochrane Library databases. Study-specific relative risks (RR) were pooled in both categorical and dose-response meta-analyses. Out of seventeen identified studies, sixteen were included in the meta-analysis. Comparing the highest with the lowest intake category, inverse associations for phyto-oestrogens overall and by subgroup were observed but were statistically significant in case-controls studies and not in cohort studies. The pooled RR in case-control studies were 0·76 (95 % CI 0·69, 0·84), 0·77 (95 % CI 0·69, 0·85) and 0·70 (95 % CI 0·56, 0·89) for phyto-oestrogens, isoflavones and lignans, respectively, whereas the corresponding pooled RR were 0·95 (95 % CI 0·85, 1·06), 0·94 (95 % CI 0·84, 1·05) and 1·00 (95 % CI 0·64, 1·57) in cohort studies. Dose-response analysis yielded an 8 % reduced risk of colorectal neoplasms for every 20 mg/d increase in isoflavones intake in Asians (pooled RR 0·92; 95 % CI 0·86, 0·97). A non-linear inverse association with colorectal cancer risk was found for lignans intake, but no association for circulating enterolactone concentrations was observed. Thus, study heterogeneity precludes a rigorous conclusion regarding an effect of high exposure to isoflavones on risk of colorectal cancer. Current evidence for an association with lignans exposure is limited. Further prospective studies, particularly evaluating lignans, are warranted to clarify the association between different phyto-oestrogens and colorectal cancer risk.",
keywords = "Adenoma, Animals, Colorectal Neoplasms, Evidence-Based Medicine, Female, Functional Food, Healthy Diet, Humans, Incidence, Isoflavones, Lignans, Male, Observational Studies as Topic, Phytoestrogens, Reproducibility of Results, Risk, Sex Factors, Soy Foods, Comparative Study, Journal Article, Meta-Analysis, Review",
author = "Ruijingfang Jiang and Akke Botma and Anja Rudolph and Anika H{\"u}sing and Jenny Chang-Claude",
year = "2016",
month = dec,
doi = "10.1017/S0007114516004360",
language = "English",
volume = "116",
pages = "2115--2128",
journal = "BRIT J NUTR",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Phyto-oestrogens and colorectal cancer risk: a systematic review and dose-response meta-analysis of observational studies

AU - Jiang, Ruijingfang

AU - Botma, Akke

AU - Rudolph, Anja

AU - Hüsing, Anika

AU - Chang-Claude, Jenny

PY - 2016/12

Y1 - 2016/12

N2 - Epidemiological studies suggest that soya consumption as a source of phyto-oestrogens and isoflavones may be associated with a reduced risk of colorectal cancer. However, findings have not yet been synthesised for all groups of phyto-oestrogens. A meta-analysis was conducted to quantify the association between phyto-oestrogens and colorectal cancer risk. Relevant observational studies published up to June 2016 were identified by searching MEDLINE, EMBASE and Cochrane Library databases. Study-specific relative risks (RR) were pooled in both categorical and dose-response meta-analyses. Out of seventeen identified studies, sixteen were included in the meta-analysis. Comparing the highest with the lowest intake category, inverse associations for phyto-oestrogens overall and by subgroup were observed but were statistically significant in case-controls studies and not in cohort studies. The pooled RR in case-control studies were 0·76 (95 % CI 0·69, 0·84), 0·77 (95 % CI 0·69, 0·85) and 0·70 (95 % CI 0·56, 0·89) for phyto-oestrogens, isoflavones and lignans, respectively, whereas the corresponding pooled RR were 0·95 (95 % CI 0·85, 1·06), 0·94 (95 % CI 0·84, 1·05) and 1·00 (95 % CI 0·64, 1·57) in cohort studies. Dose-response analysis yielded an 8 % reduced risk of colorectal neoplasms for every 20 mg/d increase in isoflavones intake in Asians (pooled RR 0·92; 95 % CI 0·86, 0·97). A non-linear inverse association with colorectal cancer risk was found for lignans intake, but no association for circulating enterolactone concentrations was observed. Thus, study heterogeneity precludes a rigorous conclusion regarding an effect of high exposure to isoflavones on risk of colorectal cancer. Current evidence for an association with lignans exposure is limited. Further prospective studies, particularly evaluating lignans, are warranted to clarify the association between different phyto-oestrogens and colorectal cancer risk.

AB - Epidemiological studies suggest that soya consumption as a source of phyto-oestrogens and isoflavones may be associated with a reduced risk of colorectal cancer. However, findings have not yet been synthesised for all groups of phyto-oestrogens. A meta-analysis was conducted to quantify the association between phyto-oestrogens and colorectal cancer risk. Relevant observational studies published up to June 2016 were identified by searching MEDLINE, EMBASE and Cochrane Library databases. Study-specific relative risks (RR) were pooled in both categorical and dose-response meta-analyses. Out of seventeen identified studies, sixteen were included in the meta-analysis. Comparing the highest with the lowest intake category, inverse associations for phyto-oestrogens overall and by subgroup were observed but were statistically significant in case-controls studies and not in cohort studies. The pooled RR in case-control studies were 0·76 (95 % CI 0·69, 0·84), 0·77 (95 % CI 0·69, 0·85) and 0·70 (95 % CI 0·56, 0·89) for phyto-oestrogens, isoflavones and lignans, respectively, whereas the corresponding pooled RR were 0·95 (95 % CI 0·85, 1·06), 0·94 (95 % CI 0·84, 1·05) and 1·00 (95 % CI 0·64, 1·57) in cohort studies. Dose-response analysis yielded an 8 % reduced risk of colorectal neoplasms for every 20 mg/d increase in isoflavones intake in Asians (pooled RR 0·92; 95 % CI 0·86, 0·97). A non-linear inverse association with colorectal cancer risk was found for lignans intake, but no association for circulating enterolactone concentrations was observed. Thus, study heterogeneity precludes a rigorous conclusion regarding an effect of high exposure to isoflavones on risk of colorectal cancer. Current evidence for an association with lignans exposure is limited. Further prospective studies, particularly evaluating lignans, are warranted to clarify the association between different phyto-oestrogens and colorectal cancer risk.

KW - Adenoma

KW - Animals

KW - Colorectal Neoplasms

KW - Evidence-Based Medicine

KW - Female

KW - Functional Food

KW - Healthy Diet

KW - Humans

KW - Incidence

KW - Isoflavones

KW - Lignans

KW - Male

KW - Observational Studies as Topic

KW - Phytoestrogens

KW - Reproducibility of Results

KW - Risk

KW - Sex Factors

KW - Soy Foods

KW - Comparative Study

KW - Journal Article

KW - Meta-Analysis

KW - Review

U2 - 10.1017/S0007114516004360

DO - 10.1017/S0007114516004360

M3 - SCORING: Journal article

C2 - 28091359

VL - 116

SP - 2115

EP - 2128

JO - BRIT J NUTR

JF - BRIT J NUTR

SN - 0007-1145

IS - 12

ER -