Physiological aspects of cardiac tissue engineering.
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Physiological aspects of cardiac tissue engineering. / Eschenhagen, Thomas; Eder, Alexandra; Vollert, Ingra; Hansen, Arne.
In: AM J PHYSIOL-HEART C, Vol. 303, No. 2, 2, 2012, p. 133-143.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Physiological aspects of cardiac tissue engineering.
AU - Eschenhagen, Thomas
AU - Eder, Alexandra
AU - Vollert, Ingra
AU - Hansen, Arne
PY - 2012
Y1 - 2012
N2 - Cardiac tissue engineering aims at repairing the diseased heart and developing cardiac tissues for basic research and predictive toxicology applications. Since the first description of engineered heart tissue 15 years ago, major development steps were directed toward these three goals. Technical innovations led to improved three-dimensional cardiac tissue structure and near physiological contractile force development. Automation and standardization allow medium throughput screening. Larger constructs composed of many small engineered heart tissues or stacked cell sheet tissues were tested for cardiac repair and were associated with functional improvements in rats. Whether these approaches can be simply transferred to larger animals or the human patients remains to be tested. The availability of an unrestricted human cardiac myocyte cell source from human embryonic stem cells or human-induced pluripotent stem cells is a major breakthrough. This review summarizes current tissue engineering techniques with their strengths and limitations and possible future applications.
AB - Cardiac tissue engineering aims at repairing the diseased heart and developing cardiac tissues for basic research and predictive toxicology applications. Since the first description of engineered heart tissue 15 years ago, major development steps were directed toward these three goals. Technical innovations led to improved three-dimensional cardiac tissue structure and near physiological contractile force development. Automation and standardization allow medium throughput screening. Larger constructs composed of many small engineered heart tissues or stacked cell sheet tissues were tested for cardiac repair and were associated with functional improvements in rats. Whether these approaches can be simply transferred to larger animals or the human patients remains to be tested. The availability of an unrestricted human cardiac myocyte cell source from human embryonic stem cells or human-induced pluripotent stem cells is a major breakthrough. This review summarizes current tissue engineering techniques with their strengths and limitations and possible future applications.
KW - Animals
KW - Humans
KW - Mice
KW - Rats
KW - Tissue Engineering/methods
KW - Heart/physiology
KW - Embryonic Stem Cells/physiology
KW - Heart Diseases/therapy
KW - Pluripotent Stem Cells/physiology
KW - Animals
KW - Humans
KW - Mice
KW - Rats
KW - Tissue Engineering/methods
KW - Heart/physiology
KW - Embryonic Stem Cells/physiology
KW - Heart Diseases/therapy
KW - Pluripotent Stem Cells/physiology
M3 - SCORING: Journal article
VL - 303
SP - 133
EP - 143
JO - AM J PHYSIOL-HEART C
JF - AM J PHYSIOL-HEART C
SN - 0363-6135
IS - 2
M1 - 2
ER -