Physical activity and risks of breast and colorectal cancer
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Physical activity and risks of breast and colorectal cancer : a Mendelian randomisation analysis. / Papadimitriou, Nikos; Dimou, Niki; Tsilidis, Konstantinos K; Banbury, Barbara; Martin, Richard M; Lewis, Sarah J; Kazmi, Nabila; Robinson, Timothy M; Albanes, Demetrius; Aleksandrova, Krasimira; Berndt, Sonja I; Timothy Bishop, D; Brenner, Hermann; Buchanan, Daniel D; Bueno-de-Mesquita, Bas; Campbell, Peter T; Castellví-Bel, Sergi; Chan, Andrew T; Chang-Claude, Jenny; Ellingjord-Dale, Merete; Figueiredo, Jane C; Gallinger, Steven J; Giles, Graham G; Giovannucci, Edward; Gruber, Stephen B; Gsur, Andrea; Hampe, Jochen; Hampel, Heather; Harlid, Sophia; Harrison, Tabitha A; Hoffmeister, Michael; Hopper, John L; Hsu, Li; María Huerta, José; Huyghe, Jeroen R; Jenkins, Mark A; Keku, Temitope O; Kühn, Tilman; La Vecchia, Carlo; Le Marchand, Loic; Li, Christopher I; Li, Li; Lindblom, Annika; Lindor, Noralane M; Lynch, Brigid; Markowitz, Sanford D; Masala, Giovanna; May, Anne M; Milne, Roger; Monninkhof, Evelyn; Moreno, Lorena; Moreno, Victor; Newcomb, Polly A; Offit, Kenneth; Perduca, Vittorio; Pharoah, Paul D P; Platz, Elizabeth A; Potter, John D; Rennert, Gad; Riboli, Elio; Sánchez, Maria-Jose; Schmit, Stephanie L; Schoen, Robert E; Severi, Gianluca; Sieri, Sabina; Slattery, Martha L; Song, Mingyang; Tangen, Catherine M; Thibodeau, Stephen N; Travis, Ruth C; Trichopoulou, Antonia; Ulrich, Cornelia M; van Duijnhoven, Franzel J B; Van Guelpen, Bethany; Vodicka, Pavel; White, Emily; Wolk, Alicja; Woods, Michael O; Wu, Anna H; Peters, Ulrike; Gunter, Marc J; Murphy, Neil.
In: NAT COMMUN, Vol. 11, No. 1, 30.01.2020, p. 597.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Physical activity and risks of breast and colorectal cancer
T2 - a Mendelian randomisation analysis
AU - Papadimitriou, Nikos
AU - Dimou, Niki
AU - Tsilidis, Konstantinos K
AU - Banbury, Barbara
AU - Martin, Richard M
AU - Lewis, Sarah J
AU - Kazmi, Nabila
AU - Robinson, Timothy M
AU - Albanes, Demetrius
AU - Aleksandrova, Krasimira
AU - Berndt, Sonja I
AU - Timothy Bishop, D
AU - Brenner, Hermann
AU - Buchanan, Daniel D
AU - Bueno-de-Mesquita, Bas
AU - Campbell, Peter T
AU - Castellví-Bel, Sergi
AU - Chan, Andrew T
AU - Chang-Claude, Jenny
AU - Ellingjord-Dale, Merete
AU - Figueiredo, Jane C
AU - Gallinger, Steven J
AU - Giles, Graham G
AU - Giovannucci, Edward
AU - Gruber, Stephen B
AU - Gsur, Andrea
AU - Hampe, Jochen
AU - Hampel, Heather
AU - Harlid, Sophia
AU - Harrison, Tabitha A
AU - Hoffmeister, Michael
AU - Hopper, John L
AU - Hsu, Li
AU - María Huerta, José
AU - Huyghe, Jeroen R
AU - Jenkins, Mark A
AU - Keku, Temitope O
AU - Kühn, Tilman
AU - La Vecchia, Carlo
AU - Le Marchand, Loic
AU - Li, Christopher I
AU - Li, Li
AU - Lindblom, Annika
AU - Lindor, Noralane M
AU - Lynch, Brigid
AU - Markowitz, Sanford D
AU - Masala, Giovanna
AU - May, Anne M
AU - Milne, Roger
AU - Monninkhof, Evelyn
AU - Moreno, Lorena
AU - Moreno, Victor
AU - Newcomb, Polly A
AU - Offit, Kenneth
AU - Perduca, Vittorio
AU - Pharoah, Paul D P
AU - Platz, Elizabeth A
AU - Potter, John D
AU - Rennert, Gad
AU - Riboli, Elio
AU - Sánchez, Maria-Jose
AU - Schmit, Stephanie L
AU - Schoen, Robert E
AU - Severi, Gianluca
AU - Sieri, Sabina
AU - Slattery, Martha L
AU - Song, Mingyang
AU - Tangen, Catherine M
AU - Thibodeau, Stephen N
AU - Travis, Ruth C
AU - Trichopoulou, Antonia
AU - Ulrich, Cornelia M
AU - van Duijnhoven, Franzel J B
AU - Van Guelpen, Bethany
AU - Vodicka, Pavel
AU - White, Emily
AU - Wolk, Alicja
AU - Woods, Michael O
AU - Wu, Anna H
AU - Peters, Ulrike
AU - Gunter, Marc J
AU - Murphy, Neil
PY - 2020/1/30
Y1 - 2020/1/30
N2 - Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
AB - Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
KW - Accelerometry
KW - Breast Neoplasms/genetics
KW - Colorectal Neoplasms/genetics
KW - Exercise
KW - Female
KW - Genetic Predisposition to Disease
KW - Humans
KW - Mendelian Randomization Analysis
KW - Odds Ratio
KW - Polymorphism, Single Nucleotide/genetics
KW - Risk Factors
U2 - 10.1038/s41467-020-14389-8
DO - 10.1038/s41467-020-14389-8
M3 - SCORING: Journal article
C2 - 32001714
VL - 11
SP - 597
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -