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Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study

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Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study. / Eyl, Ruth Elisa; Thong, Melissa S Y; Carr, Prudence R; Jansen, Lina; Koch-Gallenkamp, Lena; Hoffmeister, Michael; Chang-Claude, Jenny; Brenner, Hermann; Arndt, Volker.

In: BMC CANCER, Vol. 20, No. 1, 18.05.2020, p. 438.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Eyl, RE, Thong, MSY, Carr, PR, Jansen, L, Koch-Gallenkamp, L, Hoffmeister, M, Chang-Claude, J, Brenner, H & Arndt, V 2020, 'Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study', BMC CANCER, vol. 20, no. 1, pp. 438. https://doi.org/10.1186/s12885-020-06918-x

APA

Eyl, R. E., Thong, M. S. Y., Carr, P. R., Jansen, L., Koch-Gallenkamp, L., Hoffmeister, M., Chang-Claude, J., Brenner, H., & Arndt, V. (2020). Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study. BMC CANCER, 20(1), 438. https://doi.org/10.1186/s12885-020-06918-x

Vancouver

Eyl RE, Thong MSY, Carr PR, Jansen L, Koch-Gallenkamp L, Hoffmeister M et al. Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study. BMC CANCER. 2020 May 18;20(1):438. https://doi.org/10.1186/s12885-020-06918-x

Bibtex

@article{7cfffe9a679043df9a0bb7f45bfdee5b,
title = "Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study",
abstract = "BACKGROUND: Evidence suggests that physical activity (PA) is beneficial for reducing fatigue in colorectal cancer (CRC) survivors. However, little is known regarding long-term effects of PA on fatigue and whether pre-diagnosis PA is associated with less fatigue in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term fatigue in CRC survivors.METHODS: This study used a German population-based cohort of 1781 individuals, diagnosed with CRC in 2003-2014, and alive at five-year follow-up (5YFU). Physical activity was assessed at diagnosis and at 5YFU. Fatigue was assessed by the Fatigue Assessment Questionnaire and the EORTC Quality of Life Questionnaire-Core 30 fatigue subscale at 5YFU. Multivariable linear regression was used to explore associations between pre- and post-diagnosis PA and fatigue at 5YFU.RESULTS: No evidence was found that pre-diagnosis PA was associated with less fatigue in long-term CRC survivors. Pre-diagnosis work-related PA and vigorous PA were even associated with higher levels of physical (Beta ({\ss}) = 2.52, 95% confidence interval (CI) = 1.14-3.90; {\ss} = 2.03, CI = 0.65-3.41), cognitive ({\ss} = 0.17, CI = 0.05-0.28; {\ss} = 0.13, CI = 0.01-0.25), and affective fatigue ({\ss} = 0.26, CI = 0.07-0.46; {\ss} = 0.21, CI = 0.02-0.40). In cross-sectional analyses, post-diagnosis PA was strongly associated with lower fatigue on all scales.CONCLUSIONS: In this study, pre-diagnosis PA does not appear to be associated with less fatigue among long-term CRC survivors. Our results support the importance of ongoing PA in long-term CRC survivors. Our findings might be used as a basis for further research on specific PA interventions to improve the long-term outcome of CRC survivors.",
author = "Eyl, {Ruth Elisa} and Thong, {Melissa S Y} and Carr, {Prudence R} and Lina Jansen and Lena Koch-Gallenkamp and Michael Hoffmeister and Jenny Chang-Claude and Hermann Brenner and Volker Arndt",
year = "2020",
month = may,
day = "18",
doi = "10.1186/s12885-020-06918-x",
language = "English",
volume = "20",
pages = "438",
journal = "BMC CANCER",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study

AU - Eyl, Ruth Elisa

AU - Thong, Melissa S Y

AU - Carr, Prudence R

AU - Jansen, Lina

AU - Koch-Gallenkamp, Lena

AU - Hoffmeister, Michael

AU - Chang-Claude, Jenny

AU - Brenner, Hermann

AU - Arndt, Volker

PY - 2020/5/18

Y1 - 2020/5/18

N2 - BACKGROUND: Evidence suggests that physical activity (PA) is beneficial for reducing fatigue in colorectal cancer (CRC) survivors. However, little is known regarding long-term effects of PA on fatigue and whether pre-diagnosis PA is associated with less fatigue in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term fatigue in CRC survivors.METHODS: This study used a German population-based cohort of 1781 individuals, diagnosed with CRC in 2003-2014, and alive at five-year follow-up (5YFU). Physical activity was assessed at diagnosis and at 5YFU. Fatigue was assessed by the Fatigue Assessment Questionnaire and the EORTC Quality of Life Questionnaire-Core 30 fatigue subscale at 5YFU. Multivariable linear regression was used to explore associations between pre- and post-diagnosis PA and fatigue at 5YFU.RESULTS: No evidence was found that pre-diagnosis PA was associated with less fatigue in long-term CRC survivors. Pre-diagnosis work-related PA and vigorous PA were even associated with higher levels of physical (Beta (ß) = 2.52, 95% confidence interval (CI) = 1.14-3.90; ß = 2.03, CI = 0.65-3.41), cognitive (ß = 0.17, CI = 0.05-0.28; ß = 0.13, CI = 0.01-0.25), and affective fatigue (ß = 0.26, CI = 0.07-0.46; ß = 0.21, CI = 0.02-0.40). In cross-sectional analyses, post-diagnosis PA was strongly associated with lower fatigue on all scales.CONCLUSIONS: In this study, pre-diagnosis PA does not appear to be associated with less fatigue among long-term CRC survivors. Our results support the importance of ongoing PA in long-term CRC survivors. Our findings might be used as a basis for further research on specific PA interventions to improve the long-term outcome of CRC survivors.

AB - BACKGROUND: Evidence suggests that physical activity (PA) is beneficial for reducing fatigue in colorectal cancer (CRC) survivors. However, little is known regarding long-term effects of PA on fatigue and whether pre-diagnosis PA is associated with less fatigue in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term fatigue in CRC survivors.METHODS: This study used a German population-based cohort of 1781 individuals, diagnosed with CRC in 2003-2014, and alive at five-year follow-up (5YFU). Physical activity was assessed at diagnosis and at 5YFU. Fatigue was assessed by the Fatigue Assessment Questionnaire and the EORTC Quality of Life Questionnaire-Core 30 fatigue subscale at 5YFU. Multivariable linear regression was used to explore associations between pre- and post-diagnosis PA and fatigue at 5YFU.RESULTS: No evidence was found that pre-diagnosis PA was associated with less fatigue in long-term CRC survivors. Pre-diagnosis work-related PA and vigorous PA were even associated with higher levels of physical (Beta (ß) = 2.52, 95% confidence interval (CI) = 1.14-3.90; ß = 2.03, CI = 0.65-3.41), cognitive (ß = 0.17, CI = 0.05-0.28; ß = 0.13, CI = 0.01-0.25), and affective fatigue (ß = 0.26, CI = 0.07-0.46; ß = 0.21, CI = 0.02-0.40). In cross-sectional analyses, post-diagnosis PA was strongly associated with lower fatigue on all scales.CONCLUSIONS: In this study, pre-diagnosis PA does not appear to be associated with less fatigue among long-term CRC survivors. Our results support the importance of ongoing PA in long-term CRC survivors. Our findings might be used as a basis for further research on specific PA interventions to improve the long-term outcome of CRC survivors.

U2 - 10.1186/s12885-020-06918-x

DO - 10.1186/s12885-020-06918-x

M3 - SCORING: Journal article

C2 - 32423448

VL - 20

SP - 438

JO - BMC CANCER

JF - BMC CANCER

SN - 1471-2407

IS - 1

ER -