PHOTORECEPTOR DAMAGE IN TERSON SYNDROME
Standard
PHOTORECEPTOR DAMAGE IN TERSON SYNDROME. / Szeligowski, Tomasz; Fu, Dun J; Fernandez-Ledo, Noa; Birtel, Johannes; Aslam, Sher A; Patel, Chetan K; Xue, Kanmin; Charbel Issa, Peter.
In: RETINA-J RET VIT DIS, Vol. 43, No. 9, 01.09.2023, p. 1557-1562.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - PHOTORECEPTOR DAMAGE IN TERSON SYNDROME
AU - Szeligowski, Tomasz
AU - Fu, Dun J
AU - Fernandez-Ledo, Noa
AU - Birtel, Johannes
AU - Aslam, Sher A
AU - Patel, Chetan K
AU - Xue, Kanmin
AU - Charbel Issa, Peter
PY - 2023/9/1
Y1 - 2023/9/1
N2 - PURPOSE: To describe photoreceptor damage in patients with Terson syndrome as a potential cause for inconsistent clinical outcomes.METHODS: Clinical evaluation and retinal imaging in six patients.RESULTS: Four patients were women and two men, with an average age of 46.8 years (SD 8.9). Four patients suffered aneurysmal subarachnoid hemorrhage, one vertebral artery dissection, and one superior sagittal sinus thrombosis. In 11 eyes, a consistent pattern of outer retinal changes within the central retina affecting the ellipsoid zone and the outer nuclear layer was observed, indicating photoreceptor damage. Areas of photoreceptor damage showed poor spatial correlation with intraocular hemorrhage, particularly subinternal limiting membrane hemorrhage. The observed retinal abnormalities demonstrated incomplete recovery over long-term follow-up 3.5 to 8 years posthemorrhage, irrespective of surgical or conservative treatment strategy, and had variable impact on the patients' visual function.CONCLUSION: The observations suggest that photoreceptor damage in Terson syndrome likely represents a distinct manifestation of this condition, which could be caused by transient ischemia of the outer retina secondary to acute rise in intracranial pressure.
AB - PURPOSE: To describe photoreceptor damage in patients with Terson syndrome as a potential cause for inconsistent clinical outcomes.METHODS: Clinical evaluation and retinal imaging in six patients.RESULTS: Four patients were women and two men, with an average age of 46.8 years (SD 8.9). Four patients suffered aneurysmal subarachnoid hemorrhage, one vertebral artery dissection, and one superior sagittal sinus thrombosis. In 11 eyes, a consistent pattern of outer retinal changes within the central retina affecting the ellipsoid zone and the outer nuclear layer was observed, indicating photoreceptor damage. Areas of photoreceptor damage showed poor spatial correlation with intraocular hemorrhage, particularly subinternal limiting membrane hemorrhage. The observed retinal abnormalities demonstrated incomplete recovery over long-term follow-up 3.5 to 8 years posthemorrhage, irrespective of surgical or conservative treatment strategy, and had variable impact on the patients' visual function.CONCLUSION: The observations suggest that photoreceptor damage in Terson syndrome likely represents a distinct manifestation of this condition, which could be caused by transient ischemia of the outer retina secondary to acute rise in intracranial pressure.
KW - Male
KW - Humans
KW - Female
KW - Middle Aged
KW - Vitreous Hemorrhage/etiology
KW - Macula Lutea
KW - Retina
KW - Subarachnoid Hemorrhage/complications
KW - Visual Acuity
KW - Tomography, Optical Coherence/methods
U2 - 10.1097/IAE.0000000000003842
DO - 10.1097/IAE.0000000000003842
M3 - SCORING: Journal article
C2 - 37253246
VL - 43
SP - 1557
EP - 1562
JO - RETINA-J RET VIT DIS
JF - RETINA-J RET VIT DIS
SN - 0275-004X
IS - 9
ER -