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Phonological decisions require both the left and right supramarginal gyri.

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Phonological decisions require both the left and right supramarginal gyri. / Hartwigsen, Gesa; Baumgärtner, Annette; Price, Cathy J; Koehnke, Maria; Ulmer, Stephan; Siebner, Hartwig R.

In: P NATL ACAD SCI USA, Vol. 107, No. 38, 38, 2010, p. 16494-16499.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hartwigsen, G, Baumgärtner, A, Price, CJ, Koehnke, M, Ulmer, S & Siebner, HR 2010, 'Phonological decisions require both the left and right supramarginal gyri.', P NATL ACAD SCI USA, vol. 107, no. 38, 38, pp. 16494-16499. <http://www.ncbi.nlm.nih.gov/pubmed/20807747?dopt=Citation>

APA

Hartwigsen, G., Baumgärtner, A., Price, C. J., Koehnke, M., Ulmer, S., & Siebner, H. R. (2010). Phonological decisions require both the left and right supramarginal gyri. P NATL ACAD SCI USA, 107(38), 16494-16499. [38]. http://www.ncbi.nlm.nih.gov/pubmed/20807747?dopt=Citation

Vancouver

Hartwigsen G, Baumgärtner A, Price CJ, Koehnke M, Ulmer S, Siebner HR. Phonological decisions require both the left and right supramarginal gyri. P NATL ACAD SCI USA. 2010;107(38):16494-16499. 38.

Bibtex

@article{3b690c6a35fd4f21b5b9ad325bddbaaa,
title = "Phonological decisions require both the left and right supramarginal gyri.",
abstract = "Recent functional imaging studies demonstrated that both the left and right supramarginal gyri (SMG) are activated when healthy right-handed subjects make phonological word decisions. However, lesion studies typically report difficulties with phonological processing after left rather than right hemisphere damage. Here, we used a unique dual-site transcranial magnetic stimulation (TMS) approach to test whether the SMG in the right hemisphere contributes to modality-independent (i.e., auditory and visual) phonological decisions. To test task-specificity, we compared the effect of real or sham TMS during phonological, semantic, and perceptual decisions. To test laterality and anatomical specificity, we compared the effect of TMS over the left, right, or bilateral SMG and angular gyri. The accuracy and reaction times of phonological decisions were selectively disrupted relative to semantic and perceptual decisions when real TMS was applied over the left, right, or bilateral SMG. These effects were not observed for TMS over the angular gyri. A follow-up experiment indicated that the threshold-intensity for inducing a disruptive effect on phonological decisions was identical for unilateral TMS over the right or left SMG. Taken together, these findings provide converging evidence that the right SMG contributes to accurate and efficient phonological decisions in the healthy brain, with no evidence that the left and right SMG can compensate for one another during TMS. Our findings motivate detailed studies of phonological processing in patients with acute or long-term damage of the right SMG.",
keywords = "Adult, Humans, Male, Female, Young Adult, Magnetic Resonance Imaging, Brain Mapping, Functional Laterality physiology, Parietal Lobe physiology, Reaction Time physiology, Transcranial Magnetic Stimulation, Semantics, Auditory Perception, Decision Making, Language, Adult, Humans, Male, Female, Young Adult, Magnetic Resonance Imaging, Brain Mapping, Functional Laterality physiology, Parietal Lobe physiology, Reaction Time physiology, Transcranial Magnetic Stimulation, Semantics, Auditory Perception, Decision Making, Language",
author = "Gesa Hartwigsen and Annette Baumg{\"a}rtner and Price, {Cathy J} and Maria Koehnke and Stephan Ulmer and Siebner, {Hartwig R}",
year = "2010",
language = "Deutsch",
volume = "107",
pages = "16494--16499",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "38",

}

RIS

TY - JOUR

T1 - Phonological decisions require both the left and right supramarginal gyri.

AU - Hartwigsen, Gesa

AU - Baumgärtner, Annette

AU - Price, Cathy J

AU - Koehnke, Maria

AU - Ulmer, Stephan

AU - Siebner, Hartwig R

PY - 2010

Y1 - 2010

N2 - Recent functional imaging studies demonstrated that both the left and right supramarginal gyri (SMG) are activated when healthy right-handed subjects make phonological word decisions. However, lesion studies typically report difficulties with phonological processing after left rather than right hemisphere damage. Here, we used a unique dual-site transcranial magnetic stimulation (TMS) approach to test whether the SMG in the right hemisphere contributes to modality-independent (i.e., auditory and visual) phonological decisions. To test task-specificity, we compared the effect of real or sham TMS during phonological, semantic, and perceptual decisions. To test laterality and anatomical specificity, we compared the effect of TMS over the left, right, or bilateral SMG and angular gyri. The accuracy and reaction times of phonological decisions were selectively disrupted relative to semantic and perceptual decisions when real TMS was applied over the left, right, or bilateral SMG. These effects were not observed for TMS over the angular gyri. A follow-up experiment indicated that the threshold-intensity for inducing a disruptive effect on phonological decisions was identical for unilateral TMS over the right or left SMG. Taken together, these findings provide converging evidence that the right SMG contributes to accurate and efficient phonological decisions in the healthy brain, with no evidence that the left and right SMG can compensate for one another during TMS. Our findings motivate detailed studies of phonological processing in patients with acute or long-term damage of the right SMG.

AB - Recent functional imaging studies demonstrated that both the left and right supramarginal gyri (SMG) are activated when healthy right-handed subjects make phonological word decisions. However, lesion studies typically report difficulties with phonological processing after left rather than right hemisphere damage. Here, we used a unique dual-site transcranial magnetic stimulation (TMS) approach to test whether the SMG in the right hemisphere contributes to modality-independent (i.e., auditory and visual) phonological decisions. To test task-specificity, we compared the effect of real or sham TMS during phonological, semantic, and perceptual decisions. To test laterality and anatomical specificity, we compared the effect of TMS over the left, right, or bilateral SMG and angular gyri. The accuracy and reaction times of phonological decisions were selectively disrupted relative to semantic and perceptual decisions when real TMS was applied over the left, right, or bilateral SMG. These effects were not observed for TMS over the angular gyri. A follow-up experiment indicated that the threshold-intensity for inducing a disruptive effect on phonological decisions was identical for unilateral TMS over the right or left SMG. Taken together, these findings provide converging evidence that the right SMG contributes to accurate and efficient phonological decisions in the healthy brain, with no evidence that the left and right SMG can compensate for one another during TMS. Our findings motivate detailed studies of phonological processing in patients with acute or long-term damage of the right SMG.

KW - Adult

KW - Humans

KW - Male

KW - Female

KW - Young Adult

KW - Magnetic Resonance Imaging

KW - Brain Mapping

KW - Functional Laterality physiology

KW - Parietal Lobe physiology

KW - Reaction Time physiology

KW - Transcranial Magnetic Stimulation

KW - Semantics

KW - Auditory Perception

KW - Decision Making

KW - Language

KW - Adult

KW - Humans

KW - Male

KW - Female

KW - Young Adult

KW - Magnetic Resonance Imaging

KW - Brain Mapping

KW - Functional Laterality physiology

KW - Parietal Lobe physiology

KW - Reaction Time physiology

KW - Transcranial Magnetic Stimulation

KW - Semantics

KW - Auditory Perception

KW - Decision Making

KW - Language

M3 - SCORING: Zeitschriftenaufsatz

VL - 107

SP - 16494

EP - 16499

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 38

M1 - 38

ER -