Phase III study of doxorubicin/cyclophosphamide with concomitant versus sequential docetaxel as adjuvant treatment in patients with human epidermal growth factor receptor 2-normal, node-positive breast cancer: BCIRG-005 trial.

  • Wolfgang Eiermann
  • Tadeusz Pienkowski
  • John Crown
  • Saeed Sadeghi
  • Miguel Martin
  • Arlene Chan
  • Mansoor Saleh
  • Sandeep Sehdev
  • Louise Provencher
  • Vladimir Semiglazov
  • Michael Press
  • Guido Sauter
  • Mary-Ann Lindsay
  • Alessandro Riva
  • Marc Buyse
  • Philippe Drevot
  • Henry Taupin
  • John R Mackey

Related Research units

Abstract

Anthracyclines, taxanes, and alkylating agents are among the most active agents in treatment of adjuvant breast cancer (BC), but the optimal schedule for their administration is unknown. We performed an adjuvant trial to compare the sequential regimen of doxorubicin with cyclophosphamide (AC) followed by docetaxel (ie, AC>T) with the combination regimen of TAC.

Bibliographical data

Original languageEnglish
Article number29
ISSN0732-183X
Publication statusPublished - 2011
pubmed 21911726