Pharmakoökonomie der Akne--Bewertung von Nutzen und Wirtschaftlichkeit
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Pharmakoökonomie der Akne--Bewertung von Nutzen und Wirtschaftlichkeit. / Radtke, Marc A; Schäfer, Ines; Augustin, Matthias.
In: J DTSCH DERMATOL GES, Vol. 8 Suppl 1, 01.03.2010, p. S105-14.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Pharmakoökonomie der Akne--Bewertung von Nutzen und Wirtschaftlichkeit
AU - Radtke, Marc A
AU - Schäfer, Ines
AU - Augustin, Matthias
PY - 2010/3/1
Y1 - 2010/3/1
N2 - INTRODUCTION: Acne belongs to the most common skin diseases and has a prevalence in the adolescence of nearly 100% and in adults of about 4%. The quality of life indes is significantly reduced und has impact on daily activities and social life and physical and psychological well being as well. The socioeconomic relevance is based not only on its prevalence but on direct and indirect costs. For acne therapy the knowledge on therapeutic costs is of importance but the cost benefit ratio as well.GOAL: Evidence of therapeutic costs in acne and economic benefit of the therapy.METHODS: Systematic review of Cochrane data.RESULTS: Calculations reveal general costs of acne treatment in Germany over 400 Mill.Euro per year. For the treatment with topical retinoids, BPO and antibiotics as well as systemic drugs only a few studies on costeffectiveness are available. For topical treatments results are not conclusive and dependent on the different health systems. New topical combinations may have a better economic outcome, however, more studies are needed. With regard to systemic therapies of moderate to severe acne based on the international references the costbenefit ratio favours the treatment with oral isotretinoin on the longterm outcome. Superiority is based on the relationship of costs and clinical outcome and the increased quality of life as well (cost-benefit ratio). It has to be emphazised that only longterm observations over years will lead to a valid calculation of costs and benefit. FACIT: Taking the high social and quality of life impact into consideration an early, well targeted and effective therapy is prevailing. Initial higher cost are balanced by a high quality of outcome under experienced dermatological supervision. The patients benefit is ranked over the final costs because of its medical, social and ethical aspects. To sample more differentiated data on pharmacoeconomic aspects well designed new clinical studies are to be set up.
AB - INTRODUCTION: Acne belongs to the most common skin diseases and has a prevalence in the adolescence of nearly 100% and in adults of about 4%. The quality of life indes is significantly reduced und has impact on daily activities and social life and physical and psychological well being as well. The socioeconomic relevance is based not only on its prevalence but on direct and indirect costs. For acne therapy the knowledge on therapeutic costs is of importance but the cost benefit ratio as well.GOAL: Evidence of therapeutic costs in acne and economic benefit of the therapy.METHODS: Systematic review of Cochrane data.RESULTS: Calculations reveal general costs of acne treatment in Germany over 400 Mill.Euro per year. For the treatment with topical retinoids, BPO and antibiotics as well as systemic drugs only a few studies on costeffectiveness are available. For topical treatments results are not conclusive and dependent on the different health systems. New topical combinations may have a better economic outcome, however, more studies are needed. With regard to systemic therapies of moderate to severe acne based on the international references the costbenefit ratio favours the treatment with oral isotretinoin on the longterm outcome. Superiority is based on the relationship of costs and clinical outcome and the increased quality of life as well (cost-benefit ratio). It has to be emphazised that only longterm observations over years will lead to a valid calculation of costs and benefit. FACIT: Taking the high social and quality of life impact into consideration an early, well targeted and effective therapy is prevailing. Initial higher cost are balanced by a high quality of outcome under experienced dermatological supervision. The patients benefit is ranked over the final costs because of its medical, social and ethical aspects. To sample more differentiated data on pharmacoeconomic aspects well designed new clinical studies are to be set up.
KW - Acne Vulgaris
KW - Adolescent
KW - Adult
KW - Child
KW - Cost-Benefit Analysis
KW - Cross-Sectional Studies
KW - Drug Costs
KW - Germany
KW - Humans
KW - National Health Programs
KW - Quality of Life
KW - Young Adult
U2 - 10.1111/j.1610-0387.2009.07175.x
DO - 10.1111/j.1610-0387.2009.07175.x
M3 - SCORING: Zeitschriftenaufsatz
C2 - 20482687
VL - 8 Suppl 1
SP - S105-14
JO - J DTSCH DERMATOL GES
JF - J DTSCH DERMATOL GES
SN - 1610-0379
ER -