Pharmacological dissociation of novelty responses in the human brain
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Pharmacological dissociation of novelty responses in the human brain. / Bunzeck, Nico; Guitart-Masip, Marc; Dolan, Raymond J; Duzel, Emrah.
In: CEREB CORTEX, Vol. 24, No. 5, 01.05.2014, p. 1351-60.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Pharmacological dissociation of novelty responses in the human brain
AU - Bunzeck, Nico
AU - Guitart-Masip, Marc
AU - Dolan, Raymond J
AU - Duzel, Emrah
PY - 2014/5/1
Y1 - 2014/5/1
N2 - Repeated processing of the same information is associated with decreased neuronal responses, termed repetition suppression (RS). Although RS effects (i.e., the difference in activity between novel and repeated stimuli) have been demonstrated within several brain regions, such as the medial temporal lobe, their precise neural mechanisms still remain unclear. Here, we used functional magnetic resonance imaging together with psychopharmacology in 48 healthy human subjects, demonstrating that RS effects within the mesolimbic system are differentially modulated by cholinergic and dopaminergic stimulation. The dopamine precursor levodopa (100 mg) attenuated RS within the hippocampus, parahippocampal cortex, and substantia nigra/ventral tegmental area, and the degree of this reduction correlated with recognition memory performance 24 h later. The acetylcholinesterase inhibitor galantamine (8 mg), in contrast, reversed RS into repetition enhancement, showing no relationship to subsequent recognition memory. This suggests that novelty sensitive neural populations of the mesolimbic system can dynamically shift their responses depending on the balance of cholinergic and dopaminergic neurotransmission, and these shifts can influence memory retention.
AB - Repeated processing of the same information is associated with decreased neuronal responses, termed repetition suppression (RS). Although RS effects (i.e., the difference in activity between novel and repeated stimuli) have been demonstrated within several brain regions, such as the medial temporal lobe, their precise neural mechanisms still remain unclear. Here, we used functional magnetic resonance imaging together with psychopharmacology in 48 healthy human subjects, demonstrating that RS effects within the mesolimbic system are differentially modulated by cholinergic and dopaminergic stimulation. The dopamine precursor levodopa (100 mg) attenuated RS within the hippocampus, parahippocampal cortex, and substantia nigra/ventral tegmental area, and the degree of this reduction correlated with recognition memory performance 24 h later. The acetylcholinesterase inhibitor galantamine (8 mg), in contrast, reversed RS into repetition enhancement, showing no relationship to subsequent recognition memory. This suggests that novelty sensitive neural populations of the mesolimbic system can dynamically shift their responses depending on the balance of cholinergic and dopaminergic neurotransmission, and these shifts can influence memory retention.
KW - Attention
KW - Body Weight
KW - Brain
KW - Brain Mapping
KW - Cholinesterase Inhibitors
KW - Dopamine Agents
KW - Exploratory Behavior
KW - Female
KW - Galantamine
KW - Healthy Volunteers
KW - Humans
KW - Levodopa
KW - Magnetic Resonance Imaging
KW - Male
KW - Neural Pathways
KW - Photic Stimulation
KW - Reaction Time
KW - Recognition (Psychology)
KW - Repression, Psychology
KW - Young Adult
U2 - 10.1093/cercor/bhs420
DO - 10.1093/cercor/bhs420
M3 - SCORING: Journal article
C2 - 23307638
VL - 24
SP - 1351
EP - 1360
JO - CEREB CORTEX
JF - CEREB CORTEX
SN - 1047-3211
IS - 5
ER -