Pharmacokinetics of meropenem during advanced organ support (ADVOS®) and continuous renal replacement therapy
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Pharmacokinetics of meropenem during advanced organ support (ADVOS®) and continuous renal replacement therapy. / König, Christina; Kluge, Stefan; Fuhrmann, Valentin; Jarczak, Dominik.
In: INT J ARTIF ORGANS, Vol. 44, No. 10, 10.2021, p. 783-786.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Pharmacokinetics of meropenem during advanced organ support (ADVOS®) and continuous renal replacement therapy
AU - König, Christina
AU - Kluge, Stefan
AU - Fuhrmann, Valentin
AU - Jarczak, Dominik
PY - 2021/10
Y1 - 2021/10
N2 - The advanced organ support (ADVOS) system allows to eliminate water-soluble as well as protein-bound molecules. Despite its clinical features, to date nothing is known about the elimination of clinically relevant drugs such as antiinfectives. Therefore, we report a case treated with ADVOS, continuous renal replacement therapy (CRRT), and meropenem (1 g 8-hourly) for empiric sepsis therapy monitored by meropenem drug levels. ADVOS showed more efficient elimination of meropenem compared to CRRT which has to be considered when evaluating dosing regimens.
AB - The advanced organ support (ADVOS) system allows to eliminate water-soluble as well as protein-bound molecules. Despite its clinical features, to date nothing is known about the elimination of clinically relevant drugs such as antiinfectives. Therefore, we report a case treated with ADVOS, continuous renal replacement therapy (CRRT), and meropenem (1 g 8-hourly) for empiric sepsis therapy monitored by meropenem drug levels. ADVOS showed more efficient elimination of meropenem compared to CRRT which has to be considered when evaluating dosing regimens.
U2 - 10.1177/03913988211021101
DO - 10.1177/03913988211021101
M3 - SCORING: Journal article
C2 - 34144656
VL - 44
SP - 783
EP - 786
JO - INT J ARTIF ORGANS
JF - INT J ARTIF ORGANS
SN - 0391-3988
IS - 10
ER -