PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent.
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PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent. / Gourni, Eleni; Demmer, Oliver; Schottelius, Margret; D'Alessandria, Calogero; Schulz, Stefan; Dijkgraaf, Ingrid; Schumacher, Udo; Schwaiger, Markus; Kessler, Horst; Wester, Hans-Jürgen.
In: J NUCL MED, Vol. 52, No. 11, 11, 2011, p. 1803-1810.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent.
AU - Gourni, Eleni
AU - Demmer, Oliver
AU - Schottelius, Margret
AU - D'Alessandria, Calogero
AU - Schulz, Stefan
AU - Dijkgraaf, Ingrid
AU - Schumacher, Udo
AU - Schwaiger, Markus
AU - Kessler, Horst
AU - Wester, Hans-Jürgen
PY - 2011
Y1 - 2011
N2 - The overexpression of the chemokine receptor CXCR4 plays an important role in oncology, since together with its endogenous ligand, the stromal cell-derived factor (SDF1-?), CXCR4 is involved in tumor development, growth, and organ-specific metastasis. As part of our ongoing efforts to develop highly specific CXCR4-targeted imaging probes and with the aim to assess the suitability of this ligand for first proof-of-concept studies in humans, we further evaluated the new (68)Ga-labeled high-affinity cyclic CXCR4 ligand, (68)Ga-CPCR4-2 (cyclo(D-Tyr(1)-[NMe]-D-Orn(2)-[4-(aminomethyl) benzoic acid,(68)Ga-DOTA]-Arg(3)-2-Nal(4)-Gly(5))).
AB - The overexpression of the chemokine receptor CXCR4 plays an important role in oncology, since together with its endogenous ligand, the stromal cell-derived factor (SDF1-?), CXCR4 is involved in tumor development, growth, and organ-specific metastasis. As part of our ongoing efforts to develop highly specific CXCR4-targeted imaging probes and with the aim to assess the suitability of this ligand for first proof-of-concept studies in humans, we further evaluated the new (68)Ga-labeled high-affinity cyclic CXCR4 ligand, (68)Ga-CPCR4-2 (cyclo(D-Tyr(1)-[NMe]-D-Orn(2)-[4-(aminomethyl) benzoic acid,(68)Ga-DOTA]-Arg(3)-2-Nal(4)-Gly(5))).
KW - Animals
KW - Humans
KW - Female
KW - Mice
KW - Protein Transport
KW - Substrate Specificity
KW - Isotope Labeling
KW - Gene Expression Regulation, Neoplastic
KW - Binding, Competitive
KW - Contrast Media/chemistry/diagnostic use/metabolism/pharmacokinetics
KW - Frozen Sections
KW - Gallium Radioisotopes/diagnostic use
KW - Hydrophobic and Hydrophilic Interactions
KW - Jurkat Cells
KW - Lung Neoplasms/metabolism/pathology/radionuclide imaging
KW - Peptides, Cyclic/chemistry/diagnostic use/metabolism/pharmacokinetics
KW - Positron-Emission Tomography
KW - Receptors, CXCR4/metabolism
KW - Small Cell Lung Carcinoma/metabolism/pathology/radionuclide imaging
KW - Animals
KW - Humans
KW - Female
KW - Mice
KW - Protein Transport
KW - Substrate Specificity
KW - Isotope Labeling
KW - Gene Expression Regulation, Neoplastic
KW - Binding, Competitive
KW - Contrast Media/chemistry/diagnostic use/metabolism/pharmacokinetics
KW - Frozen Sections
KW - Gallium Radioisotopes/diagnostic use
KW - Hydrophobic and Hydrophilic Interactions
KW - Jurkat Cells
KW - Lung Neoplasms/metabolism/pathology/radionuclide imaging
KW - Peptides, Cyclic/chemistry/diagnostic use/metabolism/pharmacokinetics
KW - Positron-Emission Tomography
KW - Receptors, CXCR4/metabolism
KW - Small Cell Lung Carcinoma/metabolism/pathology/radionuclide imaging
M3 - SCORING: Journal article
VL - 52
SP - 1803
EP - 1810
JO - J NUCL MED
JF - J NUCL MED
SN - 0161-5505
IS - 11
M1 - 11
ER -
