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Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

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Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. / Suez, Jotham; Cohen, Yotam; Valdés-Mas, Rafael; Mor, Uria; Dori-Bachash, Mally; Federici, Sara; Zmora, Niv; Leshem, Avner; Heinemann, Melina; Linevsky, Raquel; Zur, Maya; Ben-Zeev Brik, Rotem; Bukimer, Aurelie; Eliyahu-Miller, Shimrit; Metz, Alona; Fischbein, Ruthy; Sharov, Olga; Malitsky, Sergey; Itkin, Maxim; Stettner, Noa; Harmelin, Alon; Shapiro, Hagit; Stein-Thoeringer, Christoph K; Segal, Eran; Elinav, Eran.

In: CELL, Vol. 185, No. 18, 01.09.2022, p. 3307-3328.e19.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Suez, J, Cohen, Y, Valdés-Mas, R, Mor, U, Dori-Bachash, M, Federici, S, Zmora, N, Leshem, A, Heinemann, M, Linevsky, R, Zur, M, Ben-Zeev Brik, R, Bukimer, A, Eliyahu-Miller, S, Metz, A, Fischbein, R, Sharov, O, Malitsky, S, Itkin, M, Stettner, N, Harmelin, A, Shapiro, H, Stein-Thoeringer, CK, Segal, E & Elinav, E 2022, 'Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance', CELL, vol. 185, no. 18, pp. 3307-3328.e19. https://doi.org/10.1016/j.cell.2022.07.016

APA

Suez, J., Cohen, Y., Valdés-Mas, R., Mor, U., Dori-Bachash, M., Federici, S., Zmora, N., Leshem, A., Heinemann, M., Linevsky, R., Zur, M., Ben-Zeev Brik, R., Bukimer, A., Eliyahu-Miller, S., Metz, A., Fischbein, R., Sharov, O., Malitsky, S., Itkin, M., ... Elinav, E. (2022). Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. CELL, 185(18), 3307-3328.e19. https://doi.org/10.1016/j.cell.2022.07.016

Vancouver

Suez J, Cohen Y, Valdés-Mas R, Mor U, Dori-Bachash M, Federici S et al. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. CELL. 2022 Sep 1;185(18):3307-3328.e19. https://doi.org/10.1016/j.cell.2022.07.016

Bibtex

@article{afea67bbfaec4bbf8c043b37a44b7d9a,
title = "Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance",
abstract = "Non-nutritive sweeteners (NNS) are commonly integrated into human diet and presumed to be inert; however, animal studies suggest that they may impact the microbiome and downstream glycemic responses. We causally assessed NNS impacts in humans and their microbiomes in a randomized-controlled trial encompassing 120 healthy adults, administered saccharin, sucralose, aspartame, and stevia sachets for 2 weeks in doses lower than the acceptable daily intake, compared with controls receiving sachet-contained vehicle glucose or no supplement. As groups, each administered NNS distinctly altered stool and oral microbiome and plasma metabolome, whereas saccharin and sucralose significantly impaired glycemic responses. Importantly, gnotobiotic mice conventionalized with microbiomes from multiple top and bottom responders of each of the four NNS-supplemented groups featured glycemic responses largely reflecting those noted in respective human donors, which were preempted by distinct microbial signals, as exemplified by sucralose. Collectively, human NNS consumption may induce person-specific, microbiome-dependent glycemic alterations, necessitating future assessment of clinical implications.",
keywords = "Adult, Animals, Aspartame/pharmacology, Blood Glucose, Humans, Mice, Microbiota, Non-Nutritive Sweeteners/analysis, Saccharin/pharmacology",
author = "Jotham Suez and Yotam Cohen and Rafael Vald{\'e}s-Mas and Uria Mor and Mally Dori-Bachash and Sara Federici and Niv Zmora and Avner Leshem and Melina Heinemann and Raquel Linevsky and Maya Zur and {Ben-Zeev Brik}, Rotem and Aurelie Bukimer and Shimrit Eliyahu-Miller and Alona Metz and Ruthy Fischbein and Olga Sharov and Sergey Malitsky and Maxim Itkin and Noa Stettner and Alon Harmelin and Hagit Shapiro and Stein-Thoeringer, {Christoph K} and Eran Segal and Eran Elinav",
note = "Copyright {\textcopyright} 2022 Elsevier Inc. All rights reserved.",
year = "2022",
month = sep,
day = "1",
doi = "10.1016/j.cell.2022.07.016",
language = "English",
volume = "185",
pages = "3307--3328.e19",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "18",

}

RIS

TY - JOUR

T1 - Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

AU - Suez, Jotham

AU - Cohen, Yotam

AU - Valdés-Mas, Rafael

AU - Mor, Uria

AU - Dori-Bachash, Mally

AU - Federici, Sara

AU - Zmora, Niv

AU - Leshem, Avner

AU - Heinemann, Melina

AU - Linevsky, Raquel

AU - Zur, Maya

AU - Ben-Zeev Brik, Rotem

AU - Bukimer, Aurelie

AU - Eliyahu-Miller, Shimrit

AU - Metz, Alona

AU - Fischbein, Ruthy

AU - Sharov, Olga

AU - Malitsky, Sergey

AU - Itkin, Maxim

AU - Stettner, Noa

AU - Harmelin, Alon

AU - Shapiro, Hagit

AU - Stein-Thoeringer, Christoph K

AU - Segal, Eran

AU - Elinav, Eran

N1 - Copyright © 2022 Elsevier Inc. All rights reserved.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Non-nutritive sweeteners (NNS) are commonly integrated into human diet and presumed to be inert; however, animal studies suggest that they may impact the microbiome and downstream glycemic responses. We causally assessed NNS impacts in humans and their microbiomes in a randomized-controlled trial encompassing 120 healthy adults, administered saccharin, sucralose, aspartame, and stevia sachets for 2 weeks in doses lower than the acceptable daily intake, compared with controls receiving sachet-contained vehicle glucose or no supplement. As groups, each administered NNS distinctly altered stool and oral microbiome and plasma metabolome, whereas saccharin and sucralose significantly impaired glycemic responses. Importantly, gnotobiotic mice conventionalized with microbiomes from multiple top and bottom responders of each of the four NNS-supplemented groups featured glycemic responses largely reflecting those noted in respective human donors, which were preempted by distinct microbial signals, as exemplified by sucralose. Collectively, human NNS consumption may induce person-specific, microbiome-dependent glycemic alterations, necessitating future assessment of clinical implications.

AB - Non-nutritive sweeteners (NNS) are commonly integrated into human diet and presumed to be inert; however, animal studies suggest that they may impact the microbiome and downstream glycemic responses. We causally assessed NNS impacts in humans and their microbiomes in a randomized-controlled trial encompassing 120 healthy adults, administered saccharin, sucralose, aspartame, and stevia sachets for 2 weeks in doses lower than the acceptable daily intake, compared with controls receiving sachet-contained vehicle glucose or no supplement. As groups, each administered NNS distinctly altered stool and oral microbiome and plasma metabolome, whereas saccharin and sucralose significantly impaired glycemic responses. Importantly, gnotobiotic mice conventionalized with microbiomes from multiple top and bottom responders of each of the four NNS-supplemented groups featured glycemic responses largely reflecting those noted in respective human donors, which were preempted by distinct microbial signals, as exemplified by sucralose. Collectively, human NNS consumption may induce person-specific, microbiome-dependent glycemic alterations, necessitating future assessment of clinical implications.

KW - Adult

KW - Animals

KW - Aspartame/pharmacology

KW - Blood Glucose

KW - Humans

KW - Mice

KW - Microbiota

KW - Non-Nutritive Sweeteners/analysis

KW - Saccharin/pharmacology

U2 - 10.1016/j.cell.2022.07.016

DO - 10.1016/j.cell.2022.07.016

M3 - SCORING: Journal article

C2 - 35987213

VL - 185

SP - 3307-3328.e19

JO - CELL

JF - CELL

SN - 0092-8674

IS - 18

ER -