Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference

TY - JOUR

T1 - Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference

AU - Kirchhof, Paulus

AU - Breithardt, Günter

AU - Aliot, Etienne

AU - Al Khatib, Sana

AU - Apostolakis, Stavros

AU - Auricchio, Angelo

AU - Bailleul, Christophe

AU - Bax, Jeroen

AU - Benninger, Gerlinde

AU - Blomstrom-Lundqvist, Carina

AU - Boersma, Lucas

AU - Boriani, Giuseppe

AU - Brandes, Axel

AU - Brown, Helen

AU - Brueckmann, Martina

AU - Calkins, Hugh

AU - Casadei, Barbara

AU - Clemens, Andreas

AU - Crijns, Harry

AU - Derwand, Roland

AU - Dobrev, Dobromir

AU - Ezekowitz, Michael

AU - Fetsch, Thomas

AU - Gerth, Andrea

AU - Gillis, Anne

AU - Gulizia, Michele

AU - Hack, Guido

AU - Haegeli, Laurent

AU - Hatem, Stephane

AU - Häusler, Karl Georg

AU - Heidbüchel, Hein

AU - Hernandez-Brichis, Jessica

AU - Jais, Pierre

AU - Kappenberger, Lukas

AU - Kautzner, Joseph

AU - Kim, Steven

AU - Kuck, Karl-Heinz

AU - Lane, Deirdre

AU - Leute, Angelika

AU - Lewalter, Thorsten

AU - Meyer, Ralf

AU - Mont, Lluis

AU - Moses, Gregory

AU - Mueller, Markus

AU - Münzel, Felix

AU - Näbauer, Michael

AU - Nielsen, Jens Cosedis

AU - Oeff, Michael

AU - Oto, Ali

AU - Pieske, Burkert

AU - Pisters, Ron

AU - Potpara, Tatjana

AU - Rasmussen, Lars

AU - Ravens, Ursula

AU - Reiffel, James

AU - Richard-Lordereau, Isabelle

AU - Schäfer, Herbert

AU - Schotten, Ulrich

AU - Stegink, Wim

AU - Stein, Kenneth

AU - Steinbeck, Gerhard

AU - Szumowski, Lukasz

AU - Tavazzi, Luigi

AU - Themistoclakis, Sakis

AU - Thomitzek, Karen

AU - Van Gelder, Isabelle C

AU - von Stritzky, Berndt

AU - Vincent, Alphons

AU - Werring, David

AU - Willems, Stephan

AU - Lip, Gregory Y H

AU - Camm, A John

PY - 2013/11

Y1 - 2013/11

N2 - The management of atrial fibrillation (AF) has seen marked changes in past years, with the introduction of new oral anticoagulants, new antiarrhythmic drugs, and the emergence of catheter ablation as a common intervention for rhythm control. Furthermore, new technologies enhance our ability to detect AF. Most clinical management decisions in AF patients can be based on validated parameters that encompass type of presentation, clinical factors, electrocardiogram analysis, and cardiac imaging. Despite these advances, patients with AF are still at increased risk for death, stroke, heart failure, and hospitalizations. During the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association (AFNET/EHRA) consensus conference, we identified the following opportunities to personalize management of AF in a better manner with a view to improve outcomes by integrating atrial morphology and damage, brain imaging, information on genetic predisposition, systemic or local inflammation, and markers for cardiac strain. Each of these promising avenues requires validation in the context of existing risk factors in patients. More importantly, a new taxonomy of AF may be needed based on the pathophysiological type of AF to allow personalized management of AF to come to full fruition. Continued translational research efforts are needed to personalize management of this prevalent disease in a better manner. All the efforts are expected to improve the management of patients with AF based on personalized therapy.

AB - The management of atrial fibrillation (AF) has seen marked changes in past years, with the introduction of new oral anticoagulants, new antiarrhythmic drugs, and the emergence of catheter ablation as a common intervention for rhythm control. Furthermore, new technologies enhance our ability to detect AF. Most clinical management decisions in AF patients can be based on validated parameters that encompass type of presentation, clinical factors, electrocardiogram analysis, and cardiac imaging. Despite these advances, patients with AF are still at increased risk for death, stroke, heart failure, and hospitalizations. During the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association (AFNET/EHRA) consensus conference, we identified the following opportunities to personalize management of AF in a better manner with a view to improve outcomes by integrating atrial morphology and damage, brain imaging, information on genetic predisposition, systemic or local inflammation, and markers for cardiac strain. Each of these promising avenues requires validation in the context of existing risk factors in patients. More importantly, a new taxonomy of AF may be needed based on the pathophysiological type of AF to allow personalized management of AF to come to full fruition. Continued translational research efforts are needed to personalize management of this prevalent disease in a better manner. All the efforts are expected to improve the management of patients with AF based on personalized therapy.

KW - Atrial Fibrillation/diagnosis

KW - Biomarkers/blood

KW - Brain/pathology

KW - Disease Management

KW - Echocardiography

KW - Electrocardiography

KW - Humans

KW - Magnetic Resonance Imaging

KW - Precision Medicine/methods

KW - Risk Factors

KW - Treatment Outcome

U2 - 10.1093/europace/eut232

DO - 10.1093/europace/eut232

M3 - SCORING: Journal article

C2 - 23981824

VL - 15

SP - 1540

EP - 1556

JO - EUROPACE

JF - EUROPACE

SN - 1099-5129

IS - 11

ER -