Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial

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@article{d91db73d56de4304b7e48041ddcab031,
title = "Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial",
abstract = "Background It remains unknown whether there is a causal relationship between intraoperative hypotension and postoperative neurocognitive disorders. We tested the hypothesis that personalised—compared to routine—intraoperative blood pressure management reduces the incidence of postoperative neurocognitive disorders in patients having major noncardiac surgery. Methods In this single-centre trial, 328 elective major noncardiac surgery patients were randomly allocated to receive personalised blood pressure management (i.e. maintaining intraoperative mean arterial pressure [MAP] above preoperative baseline MAP from automated 24-h blood pressure monitoring) or routine blood pressure management (i.e. maintaining MAP above 65 mm Hg). The primary outcome was the incidence of neurocognitive disorders (composite of delayed neurocognitive recovery and delirium) between postoperative days 3 and 7. Results The primary outcome, neurocognitive disorders, occurred in 18 of 147 patients (12%) assigned to personalised and 21 of 148 patients (14%) assigned to routine blood pressure management (odds ratio [OR]=0.84, 95% confidence interval [CI]: 0.40–1.75, P=0.622). Delayed neurocognitive recovery occurred in 17 of 146 patients (12%) assigned to personalised and 17 of 145 patients (12%) assigned to routine blood pressure management (OR=0.99, 95% CI: 0.45–2.17, P=0.983). Delirium occurred in 2 of 157 patients (1%) assigned to personalised and 4 of 158 patients (3%) assigned to routine blood pressure management (OR=0.50, 95% CI: 0.04–3.53, P=0.684). Conclusions Personalised intraoperative blood pressure management maintaining preoperative baseline MAP neither reduced the incidence of the composite primary outcome neurocognitive disorders between postoperative days 3 and 7 nor the incidences of the components of the composite primary outcome—delayed neurocognitive recovery and delirium—compared to routine blood pressure management in patients having major noncardiac surgery. Clinical trial registration ClinicalTrials.gov (NCT03442907).",
keywords = "anaesthesia, cardiovascular dynamics, haemodynamic monitoring, individualised, morbidity, mortality, randomised controlled trial",
author = "Nicklas, {Julia Y.} and Alina Bergholz and Francesco D{\"a}ke and Pham, {Hanh H.D.} and Marie-Christin Rabe and Hanna Schlichting and Sophia Skrovanek and Moritz Flick and Karim Kouz and Marlene Fischer and Cynthia Olotu and Izbicki, {Jakob R.} and Oliver Mann and Margit Fisch and Barbara Schmalfeldt and Karl-Heinz Frosch and Thomas Renn{\'e} and Linda Krause and Christian Z{\"o}llner and Bernd Saugel",
note = "{\textcopyright} 2024 The Author(s).",
year = "2024",
month = sep,
doi = "10.1016/j.bjao.2024.100294",
language = "English",
volume = "11",
pages = "100294",
journal = "BJA Open",
issn = "2772-6096",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial

AU - Nicklas, Julia Y.

AU - Bergholz, Alina

AU - Däke, Francesco

AU - Pham, Hanh H.D.

AU - Rabe, Marie-Christin

AU - Schlichting, Hanna

AU - Skrovanek, Sophia

AU - Flick, Moritz

AU - Kouz, Karim

AU - Fischer, Marlene

AU - Olotu, Cynthia

AU - Izbicki, Jakob R.

AU - Mann, Oliver

AU - Fisch, Margit

AU - Schmalfeldt, Barbara

AU - Frosch, Karl-Heinz

AU - Renné, Thomas

AU - Krause, Linda

AU - Zöllner, Christian

AU - Saugel, Bernd

N1 - © 2024 The Author(s).

PY - 2024/9

Y1 - 2024/9

N2 - Background It remains unknown whether there is a causal relationship between intraoperative hypotension and postoperative neurocognitive disorders. We tested the hypothesis that personalised—compared to routine—intraoperative blood pressure management reduces the incidence of postoperative neurocognitive disorders in patients having major noncardiac surgery. Methods In this single-centre trial, 328 elective major noncardiac surgery patients were randomly allocated to receive personalised blood pressure management (i.e. maintaining intraoperative mean arterial pressure [MAP] above preoperative baseline MAP from automated 24-h blood pressure monitoring) or routine blood pressure management (i.e. maintaining MAP above 65 mm Hg). The primary outcome was the incidence of neurocognitive disorders (composite of delayed neurocognitive recovery and delirium) between postoperative days 3 and 7. Results The primary outcome, neurocognitive disorders, occurred in 18 of 147 patients (12%) assigned to personalised and 21 of 148 patients (14%) assigned to routine blood pressure management (odds ratio [OR]=0.84, 95% confidence interval [CI]: 0.40–1.75, P=0.622). Delayed neurocognitive recovery occurred in 17 of 146 patients (12%) assigned to personalised and 17 of 145 patients (12%) assigned to routine blood pressure management (OR=0.99, 95% CI: 0.45–2.17, P=0.983). Delirium occurred in 2 of 157 patients (1%) assigned to personalised and 4 of 158 patients (3%) assigned to routine blood pressure management (OR=0.50, 95% CI: 0.04–3.53, P=0.684). Conclusions Personalised intraoperative blood pressure management maintaining preoperative baseline MAP neither reduced the incidence of the composite primary outcome neurocognitive disorders between postoperative days 3 and 7 nor the incidences of the components of the composite primary outcome—delayed neurocognitive recovery and delirium—compared to routine blood pressure management in patients having major noncardiac surgery. Clinical trial registration ClinicalTrials.gov (NCT03442907).

AB - Background It remains unknown whether there is a causal relationship between intraoperative hypotension and postoperative neurocognitive disorders. We tested the hypothesis that personalised—compared to routine—intraoperative blood pressure management reduces the incidence of postoperative neurocognitive disorders in patients having major noncardiac surgery. Methods In this single-centre trial, 328 elective major noncardiac surgery patients were randomly allocated to receive personalised blood pressure management (i.e. maintaining intraoperative mean arterial pressure [MAP] above preoperative baseline MAP from automated 24-h blood pressure monitoring) or routine blood pressure management (i.e. maintaining MAP above 65 mm Hg). The primary outcome was the incidence of neurocognitive disorders (composite of delayed neurocognitive recovery and delirium) between postoperative days 3 and 7. Results The primary outcome, neurocognitive disorders, occurred in 18 of 147 patients (12%) assigned to personalised and 21 of 148 patients (14%) assigned to routine blood pressure management (odds ratio [OR]=0.84, 95% confidence interval [CI]: 0.40–1.75, P=0.622). Delayed neurocognitive recovery occurred in 17 of 146 patients (12%) assigned to personalised and 17 of 145 patients (12%) assigned to routine blood pressure management (OR=0.99, 95% CI: 0.45–2.17, P=0.983). Delirium occurred in 2 of 157 patients (1%) assigned to personalised and 4 of 158 patients (3%) assigned to routine blood pressure management (OR=0.50, 95% CI: 0.04–3.53, P=0.684). Conclusions Personalised intraoperative blood pressure management maintaining preoperative baseline MAP neither reduced the incidence of the composite primary outcome neurocognitive disorders between postoperative days 3 and 7 nor the incidences of the components of the composite primary outcome—delayed neurocognitive recovery and delirium—compared to routine blood pressure management in patients having major noncardiac surgery. Clinical trial registration ClinicalTrials.gov (NCT03442907).

KW - anaesthesia

KW - cardiovascular dynamics

KW - haemodynamic monitoring

KW - individualised

KW - morbidity

KW - mortality

KW - randomised controlled trial

U2 - 10.1016/j.bjao.2024.100294

DO - 10.1016/j.bjao.2024.100294

M3 - SCORING: Journal article

C2 - 39050403

VL - 11

SP - 100294

JO - BJA Open

JF - BJA Open

SN - 2772-6096

ER -