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Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort

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Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort. / Shi, Yanyan; Strobl, Ralf; Apfelbacher, Christian; Bahmer, Thomas; Geisler, Ramsia; Heuschmann, Peter; Horn, Anna; Hoven, Hanno; Keil, Thomas; Krawczak, Michael; Krist, Lilian; Lemhöfer, Christina; Lieb, Wolfgang; Lorenz-Depiereux, Bettina; Mikolajczyk, Rafael; Montellano, Felipe A; Reese, Jens Peter; Schreiber, Stefan; Skoetz, Nicole; Störk, Stefan; Vehreschild, Jörg Janne; Witzenrath, Martin; Grill, Eva; NAPKON Study Group.

In: INFECTION, Vol. 51, No. 6, 12.2023, p. 1679-1694.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Shi, Y, Strobl, R, Apfelbacher, C, Bahmer, T, Geisler, R, Heuschmann, P, Horn, A, Hoven, H, Keil, T, Krawczak, M, Krist, L, Lemhöfer, C, Lieb, W, Lorenz-Depiereux, B, Mikolajczyk, R, Montellano, FA, Reese, JP, Schreiber, S, Skoetz, N, Störk, S, Vehreschild, JJ, Witzenrath, M, Grill, E & NAPKON Study Group 2023, 'Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort', INFECTION, vol. 51, no. 6, pp. 1679-1694. https://doi.org/10.1007/s15010-023-02043-6

APA

Shi, Y., Strobl, R., Apfelbacher, C., Bahmer, T., Geisler, R., Heuschmann, P., Horn, A., Hoven, H., Keil, T., Krawczak, M., Krist, L., Lemhöfer, C., Lieb, W., Lorenz-Depiereux, B., Mikolajczyk, R., Montellano, F. A., Reese, J. P., Schreiber, S., Skoetz, N., ... NAPKON Study Group (2023). Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort. INFECTION, 51(6), 1679-1694. https://doi.org/10.1007/s15010-023-02043-6

Vancouver

Shi Y, Strobl R, Apfelbacher C, Bahmer T, Geisler R, Heuschmann P et al. Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort. INFECTION. 2023 Dec;51(6):1679-1694. https://doi.org/10.1007/s15010-023-02043-6

Bibtex

@article{179f701e379c45ff80061f41f20c5d89,
title = "Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort",
abstract = "PURPOSE: We aimed to assess symptoms in patients after SARS-CoV-2 infection and to identify factors predicting prolonged time to symptom-free.METHODS: COVIDOM/NAPKON-POP is a population-based prospective cohort of adults whose first on-site visits were scheduled ≥ 6 months after a positive SARS-CoV-2 PCR test. Retrospective data including self-reported symptoms and time to symptom-free were collected during the survey before a site visit. In the survival analyses, being symptom-free served as the event and time to be symptom-free as the time variable. Data were visualized with Kaplan-Meier curves, differences were tested with log-rank tests. A stratified Cox proportional hazard model was used to estimate adjusted hazard ratios (aHRs) of predictors, with aHR < 1 indicating a longer time to symptom-free.RESULTS: Of 1175 symptomatic participants included in the present analysis, 636 (54.1%) reported persistent symptoms after 280 days (SD 68) post infection. 25% of participants were free from symptoms after 18 days [quartiles: 14, 21]. Factors associated with prolonged time to symptom-free were age 49-59 years compared to < 49 years (aHR 0.70, 95% CI 0.56-0.87), female sex (aHR 0.78, 95% CI 0.65-0.93), lower educational level (aHR 0.77, 95% CI 0.64-0.93), living with a partner (aHR 0.81, 95% CI 0.66-0.99), low resilience (aHR 0.65, 95% CI 0.47-0.90), steroid treatment (aHR 0.22, 95% CI 0.05-0.90) and no medication (aHR 0.74, 95% CI 0.62-0.89) during acute infection.CONCLUSION: In the studied population, COVID-19 symptoms had resolved in one-quarter of participants within 18 days, and in 34.5% within 28 days. Over half of the participants reported COVID-19-related symptoms 9 months after infection. Symptom persistence was predominantly determined by participant's characteristics that are difficult to modify.",
author = "Yanyan Shi and Ralf Strobl and Christian Apfelbacher and Thomas Bahmer and Ramsia Geisler and Peter Heuschmann and Anna Horn and Hanno Hoven and Thomas Keil and Michael Krawczak and Lilian Krist and Christina Lemh{\"o}fer and Wolfgang Lieb and Bettina Lorenz-Depiereux and Rafael Mikolajczyk and Montellano, {Felipe A} and Reese, {Jens Peter} and Stefan Schreiber and Nicole Skoetz and Stefan St{\"o}rk and Vehreschild, {J{\"o}rg Janne} and Martin Witzenrath and Eva Grill and {NAPKON Study Group} and Addo, {Marylyn Martina}",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = dec,
doi = "10.1007/s15010-023-02043-6",
language = "English",
volume = "51",
pages = "1679--1694",
journal = "INFECTION",
issn = "0300-8126",
publisher = "Urban und Vogel",
number = "6",

}

RIS

TY - JOUR

T1 - Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort

AU - Shi, Yanyan

AU - Strobl, Ralf

AU - Apfelbacher, Christian

AU - Bahmer, Thomas

AU - Geisler, Ramsia

AU - Heuschmann, Peter

AU - Horn, Anna

AU - Hoven, Hanno

AU - Keil, Thomas

AU - Krawczak, Michael

AU - Krist, Lilian

AU - Lemhöfer, Christina

AU - Lieb, Wolfgang

AU - Lorenz-Depiereux, Bettina

AU - Mikolajczyk, Rafael

AU - Montellano, Felipe A

AU - Reese, Jens Peter

AU - Schreiber, Stefan

AU - Skoetz, Nicole

AU - Störk, Stefan

AU - Vehreschild, Jörg Janne

AU - Witzenrath, Martin

AU - Grill, Eva

AU - NAPKON Study Group

AU - Addo, Marylyn Martina

N1 - © 2023. The Author(s).

PY - 2023/12

Y1 - 2023/12

N2 - PURPOSE: We aimed to assess symptoms in patients after SARS-CoV-2 infection and to identify factors predicting prolonged time to symptom-free.METHODS: COVIDOM/NAPKON-POP is a population-based prospective cohort of adults whose first on-site visits were scheduled ≥ 6 months after a positive SARS-CoV-2 PCR test. Retrospective data including self-reported symptoms and time to symptom-free were collected during the survey before a site visit. In the survival analyses, being symptom-free served as the event and time to be symptom-free as the time variable. Data were visualized with Kaplan-Meier curves, differences were tested with log-rank tests. A stratified Cox proportional hazard model was used to estimate adjusted hazard ratios (aHRs) of predictors, with aHR < 1 indicating a longer time to symptom-free.RESULTS: Of 1175 symptomatic participants included in the present analysis, 636 (54.1%) reported persistent symptoms after 280 days (SD 68) post infection. 25% of participants were free from symptoms after 18 days [quartiles: 14, 21]. Factors associated with prolonged time to symptom-free were age 49-59 years compared to < 49 years (aHR 0.70, 95% CI 0.56-0.87), female sex (aHR 0.78, 95% CI 0.65-0.93), lower educational level (aHR 0.77, 95% CI 0.64-0.93), living with a partner (aHR 0.81, 95% CI 0.66-0.99), low resilience (aHR 0.65, 95% CI 0.47-0.90), steroid treatment (aHR 0.22, 95% CI 0.05-0.90) and no medication (aHR 0.74, 95% CI 0.62-0.89) during acute infection.CONCLUSION: In the studied population, COVID-19 symptoms had resolved in one-quarter of participants within 18 days, and in 34.5% within 28 days. Over half of the participants reported COVID-19-related symptoms 9 months after infection. Symptom persistence was predominantly determined by participant's characteristics that are difficult to modify.

AB - PURPOSE: We aimed to assess symptoms in patients after SARS-CoV-2 infection and to identify factors predicting prolonged time to symptom-free.METHODS: COVIDOM/NAPKON-POP is a population-based prospective cohort of adults whose first on-site visits were scheduled ≥ 6 months after a positive SARS-CoV-2 PCR test. Retrospective data including self-reported symptoms and time to symptom-free were collected during the survey before a site visit. In the survival analyses, being symptom-free served as the event and time to be symptom-free as the time variable. Data were visualized with Kaplan-Meier curves, differences were tested with log-rank tests. A stratified Cox proportional hazard model was used to estimate adjusted hazard ratios (aHRs) of predictors, with aHR < 1 indicating a longer time to symptom-free.RESULTS: Of 1175 symptomatic participants included in the present analysis, 636 (54.1%) reported persistent symptoms after 280 days (SD 68) post infection. 25% of participants were free from symptoms after 18 days [quartiles: 14, 21]. Factors associated with prolonged time to symptom-free were age 49-59 years compared to < 49 years (aHR 0.70, 95% CI 0.56-0.87), female sex (aHR 0.78, 95% CI 0.65-0.93), lower educational level (aHR 0.77, 95% CI 0.64-0.93), living with a partner (aHR 0.81, 95% CI 0.66-0.99), low resilience (aHR 0.65, 95% CI 0.47-0.90), steroid treatment (aHR 0.22, 95% CI 0.05-0.90) and no medication (aHR 0.74, 95% CI 0.62-0.89) during acute infection.CONCLUSION: In the studied population, COVID-19 symptoms had resolved in one-quarter of participants within 18 days, and in 34.5% within 28 days. Over half of the participants reported COVID-19-related symptoms 9 months after infection. Symptom persistence was predominantly determined by participant's characteristics that are difficult to modify.

U2 - 10.1007/s15010-023-02043-6

DO - 10.1007/s15010-023-02043-6

M3 - SCORING: Journal article

C2 - 37231313

VL - 51

SP - 1679

EP - 1694

JO - INFECTION

JF - INFECTION

SN - 0300-8126

IS - 6

ER -