Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks

Maike Möller; Ame Abdu Haji; Jan Hoffmann; Arne May

doi:10.1177/0333102417738248

Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks

Standard

Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks. / Möller, Maike; Haji, Ame Abdu; Hoffmann, Jan; May, Arne.

In: CEPHALALGIA, Vol. 38, No. 8, 07.2018, p. 1498-1502.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Möller, M, Haji, AA, Hoffmann, J & May, A 2018, 'Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks', CEPHALALGIA, vol. 38, no. 8, pp. 1498-1502. https://doi.org/10.1177/0333102417738248

APA

Möller, M., Haji, A. A., Hoffmann, J., & May, A. (2018). Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks. CEPHALALGIA, 38(8), 1498-1502. https://doi.org/10.1177/0333102417738248

Vancouver

Möller M, Haji AA, Hoffmann J, May A. Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks. CEPHALALGIA. 2018 Jul;38(8):1498-1502. https://doi.org/10.1177/0333102417738248

Bibtex

@article{bb2149374d05413eb53c660f86faa033,

title = "Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks",

abstract = "Background Recently it has been suggested that low frequency stimulation of the sphenopalatine ganglion (SPG) may provoke cluster-like attacks in cluster headache (CH) patients. The question arises whether a robust activation of cranial autonomic symptoms is sufficient to trigger CH attacks. Methods Kinetic oscillation stimulation (KOS) of the nasal mucosa generates ipsilateral marked autonomic symptoms, among which lacrimation is quantitatively measurable. KOS was applied to 29 CH-patients, including both episodic and chronic course. We measured lacrimation at rest and during stimulation, and assessed CH attacks within 24 hours after the experiment. Results Autonomic symptoms including lacrimation were robust and significantly generated, compared to rest. Six patients were lost to follow-up, but did not develop an attack during their stay in the clinic. Of the remaining 23 patients, none developed an attack in the next 4 hours after stimulation, despite marked cranial autonomic symptoms during stimulation. Discussion Peripheral stimulation close to the SPG generated a strong parasympathetic response. However, this stimulation was not sufficient to induce CH attacks, which suggests that a central component is crucial to attack generation.",

keywords = "Journal Article",

author = "Maike M{\"o}ller and Haji, {Ame Abdu} and Jan Hoffmann and Arne May",

year = "2018",

month = jul,

doi = "10.1177/0333102417738248",

language = "English",

volume = "38",

pages = "1498--1502",

journal = "CEPHALALGIA",

issn = "0333-1024",

publisher = "SAGE Publications",

number = "8",

}

RIS

TY - JOUR

T1 - Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks

AU - Möller, Maike

AU - Haji, Ame Abdu

AU - Hoffmann, Jan

AU - May, Arne

PY - 2018/7

Y1 - 2018/7

N2 - Background Recently it has been suggested that low frequency stimulation of the sphenopalatine ganglion (SPG) may provoke cluster-like attacks in cluster headache (CH) patients. The question arises whether a robust activation of cranial autonomic symptoms is sufficient to trigger CH attacks. Methods Kinetic oscillation stimulation (KOS) of the nasal mucosa generates ipsilateral marked autonomic symptoms, among which lacrimation is quantitatively measurable. KOS was applied to 29 CH-patients, including both episodic and chronic course. We measured lacrimation at rest and during stimulation, and assessed CH attacks within 24 hours after the experiment. Results Autonomic symptoms including lacrimation were robust and significantly generated, compared to rest. Six patients were lost to follow-up, but did not develop an attack during their stay in the clinic. Of the remaining 23 patients, none developed an attack in the next 4 hours after stimulation, despite marked cranial autonomic symptoms during stimulation. Discussion Peripheral stimulation close to the SPG generated a strong parasympathetic response. However, this stimulation was not sufficient to induce CH attacks, which suggests that a central component is crucial to attack generation.

AB - Background Recently it has been suggested that low frequency stimulation of the sphenopalatine ganglion (SPG) may provoke cluster-like attacks in cluster headache (CH) patients. The question arises whether a robust activation of cranial autonomic symptoms is sufficient to trigger CH attacks. Methods Kinetic oscillation stimulation (KOS) of the nasal mucosa generates ipsilateral marked autonomic symptoms, among which lacrimation is quantitatively measurable. KOS was applied to 29 CH-patients, including both episodic and chronic course. We measured lacrimation at rest and during stimulation, and assessed CH attacks within 24 hours after the experiment. Results Autonomic symptoms including lacrimation were robust and significantly generated, compared to rest. Six patients were lost to follow-up, but did not develop an attack during their stay in the clinic. Of the remaining 23 patients, none developed an attack in the next 4 hours after stimulation, despite marked cranial autonomic symptoms during stimulation. Discussion Peripheral stimulation close to the SPG generated a strong parasympathetic response. However, this stimulation was not sufficient to induce CH attacks, which suggests that a central component is crucial to attack generation.

KW - Journal Article

U2 - 10.1177/0333102417738248

DO - 10.1177/0333102417738248

M3 - SCORING: Journal article

C2 - 29082823

VL - 38

SP - 1498

EP - 1502

JO - CEPHALALGIA

JF - CEPHALALGIA

SN - 0333-1024

IS - 8

ER -