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Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia

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Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia. / Montag, Christiane; Schöner, Johanna; Speck, Lucas Guilherme; Just, Sandra; Stuke, Frauke; Rentzsch, Johannes; Gallinat, Jürgen; Majić, Tomislav.

In: PLOS ONE, Vol. 15, No. 4, 2020, p. e0231257.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Montag, C, Schöner, J, Speck, LG, Just, S, Stuke, F, Rentzsch, J, Gallinat, J & Majić, T 2020, 'Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia', PLOS ONE, vol. 15, no. 4, pp. e0231257. https://doi.org/10.1371/journal.pone.0231257

APA

Montag, C., Schöner, J., Speck, L. G., Just, S., Stuke, F., Rentzsch, J., Gallinat, J., & Majić, T. (2020). Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia. PLOS ONE, 15(4), e0231257. https://doi.org/10.1371/journal.pone.0231257

Vancouver

Montag C, Schöner J, Speck LG, Just S, Stuke F, Rentzsch J et al. Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia. PLOS ONE. 2020;15(4):e0231257. https://doi.org/10.1371/journal.pone.0231257

Bibtex

@article{a704bad16d41439b851cbc44d106ad8e,
title = "Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia",
abstract = "Endogenous oxytocin has been associated with different aspects of social cognition in healthy subjects and patients with schizophrenia. In this pilot study, we investigated the relationship between plasma oxytocin and oxytocin level changes induced by empathy-eliciting, attachment-related movie scenes with correlates of cognitive and emotional empathy in patients and healthy controls. The Multifaceted Empathy Test (MET) and the Interpersonal Reactivity Index (IRI) were administered to patients with schizophrenia (N = 35, 12 females) and healthy controls (N = 35, 12 females) to estimate dimensions of cognitive and emotional empathy. Peripheral basal oxytocin concentrations and oxytocin responses to movie-based emotional stimuli were assessed using radioimmunoassay with sample extraction. In patients, induced oxytocin level changes were inversely correlated with MET cognitive empathy regarding negative emotional states. Controlling for non-social cognition and age revealed a significant negative association between basal oxytocin levels and MET cognitive empathy for positive emotions. In healthy subjects, oxytocin reactivity was inversely correlated with the IRI subscale {"}fantasy{"}. Oxytocin was not related to any measure of emotional empathy. A hyper-reactive oxytocin system might be linked to impaired cognitive empathy as a part of a dysfunctional regulative circuit of attachment-related emotions and interpersonal stressors or threats by attribution of meaning. Healthy adults with a disposition to identify with fictional characters showed lower oxytocin reactivity, possibly indicating familiarity with movie-based stimuli. The oxytocinergic system may be involved in maladaptive coping mechanisms in the framework of impaired mentalizing and associated dysfunctional responses to interpersonal challenges in schizophrenia.",
keywords = "Adaptation, Psychological, Adult, Case-Control Studies, Cognition, Empathy, Female, Humans, Male, Middle Aged, Oxytocin/blood, Pilot Projects, Radioimmunoassay, Schizophrenic Psychology",
author = "Christiane Montag and Johanna Sch{\"o}ner and Speck, {Lucas Guilherme} and Sandra Just and Frauke Stuke and Johannes Rentzsch and J{\"u}rgen Gallinat and Tomislav Maji{\'c}",
year = "2020",
doi = "10.1371/journal.pone.0231257",
language = "English",
volume = "15",
pages = "e0231257",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia

AU - Montag, Christiane

AU - Schöner, Johanna

AU - Speck, Lucas Guilherme

AU - Just, Sandra

AU - Stuke, Frauke

AU - Rentzsch, Johannes

AU - Gallinat, Jürgen

AU - Majić, Tomislav

PY - 2020

Y1 - 2020

N2 - Endogenous oxytocin has been associated with different aspects of social cognition in healthy subjects and patients with schizophrenia. In this pilot study, we investigated the relationship between plasma oxytocin and oxytocin level changes induced by empathy-eliciting, attachment-related movie scenes with correlates of cognitive and emotional empathy in patients and healthy controls. The Multifaceted Empathy Test (MET) and the Interpersonal Reactivity Index (IRI) were administered to patients with schizophrenia (N = 35, 12 females) and healthy controls (N = 35, 12 females) to estimate dimensions of cognitive and emotional empathy. Peripheral basal oxytocin concentrations and oxytocin responses to movie-based emotional stimuli were assessed using radioimmunoassay with sample extraction. In patients, induced oxytocin level changes were inversely correlated with MET cognitive empathy regarding negative emotional states. Controlling for non-social cognition and age revealed a significant negative association between basal oxytocin levels and MET cognitive empathy for positive emotions. In healthy subjects, oxytocin reactivity was inversely correlated with the IRI subscale "fantasy". Oxytocin was not related to any measure of emotional empathy. A hyper-reactive oxytocin system might be linked to impaired cognitive empathy as a part of a dysfunctional regulative circuit of attachment-related emotions and interpersonal stressors or threats by attribution of meaning. Healthy adults with a disposition to identify with fictional characters showed lower oxytocin reactivity, possibly indicating familiarity with movie-based stimuli. The oxytocinergic system may be involved in maladaptive coping mechanisms in the framework of impaired mentalizing and associated dysfunctional responses to interpersonal challenges in schizophrenia.

AB - Endogenous oxytocin has been associated with different aspects of social cognition in healthy subjects and patients with schizophrenia. In this pilot study, we investigated the relationship between plasma oxytocin and oxytocin level changes induced by empathy-eliciting, attachment-related movie scenes with correlates of cognitive and emotional empathy in patients and healthy controls. The Multifaceted Empathy Test (MET) and the Interpersonal Reactivity Index (IRI) were administered to patients with schizophrenia (N = 35, 12 females) and healthy controls (N = 35, 12 females) to estimate dimensions of cognitive and emotional empathy. Peripheral basal oxytocin concentrations and oxytocin responses to movie-based emotional stimuli were assessed using radioimmunoassay with sample extraction. In patients, induced oxytocin level changes were inversely correlated with MET cognitive empathy regarding negative emotional states. Controlling for non-social cognition and age revealed a significant negative association between basal oxytocin levels and MET cognitive empathy for positive emotions. In healthy subjects, oxytocin reactivity was inversely correlated with the IRI subscale "fantasy". Oxytocin was not related to any measure of emotional empathy. A hyper-reactive oxytocin system might be linked to impaired cognitive empathy as a part of a dysfunctional regulative circuit of attachment-related emotions and interpersonal stressors or threats by attribution of meaning. Healthy adults with a disposition to identify with fictional characters showed lower oxytocin reactivity, possibly indicating familiarity with movie-based stimuli. The oxytocinergic system may be involved in maladaptive coping mechanisms in the framework of impaired mentalizing and associated dysfunctional responses to interpersonal challenges in schizophrenia.

KW - Adaptation, Psychological

KW - Adult

KW - Case-Control Studies

KW - Cognition

KW - Empathy

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Oxytocin/blood

KW - Pilot Projects

KW - Radioimmunoassay

KW - Schizophrenic Psychology

U2 - 10.1371/journal.pone.0231257

DO - 10.1371/journal.pone.0231257

M3 - SCORING: Journal article

C2 - 32255800

VL - 15

SP - e0231257

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 4

ER -