Perioperative goal-directed therapy - What is the evidence?
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Perioperative goal-directed therapy - What is the evidence? / Kaufmann, Thomas; Saugel, Bernd; Scheeren, Thomas W L.
In: BEST PRAC RES-CL ANA, Vol. 33, No. 2, 06.2019, p. 179-187.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Perioperative goal-directed therapy - What is the evidence?
AU - Kaufmann, Thomas
AU - Saugel, Bernd
AU - Scheeren, Thomas W L
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019/6
Y1 - 2019/6
N2 - Perioperative goal-directed therapy aims at optimizing global hemodynamics during the perioperative period by titrating fluids, vasopressors, and/or inotropes to predefined hemodynamic goals. There is evidence on the benefit of perioperative goal-directed therapy, but its adoption into clinical practice is slow and incomprehensive. Current evidence indicates that treating patients according to perioperative goal-directed therapy protocols reduces morbidity and mortality, particularly in patients having high-risk surgery. Perioperative goal-directed therapy protocols need to be started early, should include vasoactive agents in addition to fluids, and should target blood flow related variables. Future promising developments in the field of perioperative goal-directed therapy include personalized hemodynamic management and closed-loop system management.
AB - Perioperative goal-directed therapy aims at optimizing global hemodynamics during the perioperative period by titrating fluids, vasopressors, and/or inotropes to predefined hemodynamic goals. There is evidence on the benefit of perioperative goal-directed therapy, but its adoption into clinical practice is slow and incomprehensive. Current evidence indicates that treating patients according to perioperative goal-directed therapy protocols reduces morbidity and mortality, particularly in patients having high-risk surgery. Perioperative goal-directed therapy protocols need to be started early, should include vasoactive agents in addition to fluids, and should target blood flow related variables. Future promising developments in the field of perioperative goal-directed therapy include personalized hemodynamic management and closed-loop system management.
U2 - 10.1016/j.bpa.2019.05.005
DO - 10.1016/j.bpa.2019.05.005
M3 - SCORING: Review article
C2 - 31582097
VL - 33
SP - 179
EP - 187
JO - BEST PRAC RES-CL ANA
JF - BEST PRAC RES-CL ANA
SN - 1521-6896
IS - 2
ER -