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Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study

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Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study. / Spahr, Axel; Klein, Elena; Khuseyinova, Natalie; Boeckh, Clemens; Muche, Rainer; Kunze, Markus; Rothenbacher, Dietrich; Pezeshki, Gita; Hoffmeister, Albrecht; Koenig, Wolfgang.

In: JAMA INTERN MED, Vol. 166, No. 5, 13.03.2006, p. 554-559.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Spahr, A, Klein, E, Khuseyinova, N, Boeckh, C, Muche, R, Kunze, M, Rothenbacher, D, Pezeshki, G, Hoffmeister, A & Koenig, W 2006, 'Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study', JAMA INTERN MED, vol. 166, no. 5, pp. 554-559. https://doi.org/10.1001/archinte.166.5.554

APA

Spahr, A., Klein, E., Khuseyinova, N., Boeckh, C., Muche, R., Kunze, M., Rothenbacher, D., Pezeshki, G., Hoffmeister, A., & Koenig, W. (2006). Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study. JAMA INTERN MED, 166(5), 554-559. https://doi.org/10.1001/archinte.166.5.554

Vancouver

Spahr A, Klein E, Khuseyinova N, Boeckh C, Muche R, Kunze M et al. Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study. JAMA INTERN MED. 2006 Mar 13;166(5):554-559. https://doi.org/10.1001/archinte.166.5.554

Bibtex

@article{5e4ccf9043d74b3c9a1378940d4f0caf,
title = "Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study",
abstract = "BACKGROUND: Chronic inflammation from any source is associated with increased cardiovascular risk. Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects.METHODS: A total of 789 subjects (263 patients with angiographically confirmed, stable CHD and 526 population-based, age- and sex-matched controls without a history of CHD) were included in the Coronary Event and Periodontal Disease (CORODONT) study. Subgingival biofilm samples were analyzed for periodontal pathogens Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Porphyromonas gingivalis, Prevotella intermedia, and Treponema denticola using DNA-DNA hybridization. The need for periodontal treatment in each subject was assessed using the Community Periodontal Index of Treatment Needs (CPITN). The main outcome measures included total periodontal pathogen burden, number of the various periodontal pathogens in the subgingival biofilm, and periodontal treatment needs (according to the CPITN).RESULTS: In multivariable analyses, we found a statistically significant association between the periodontal pathogen burden (log10 of the sum of all pathogens) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.34-2.74; P<.001) or the number of A actinomycetemcomitans in periodontal pockets (log10) (OR, 2.70; 95% CI, 1.79-4.07; P<.001) and the presence of CHD. In addition, a statistically significant association between an increase in mean CPITN score by 1 and the presence of CHD (OR, 1.67; 95% CI, 1.08-2.58; P = .02) was observed.CONCLUSIONS: Our findings suggest an association between periodontitis and presence of CHD. Periodontal pathogen burden, and particularly infection with A actinomycetemcomitans, may be of special importance.",
keywords = "Adult, Aged, Bacteroidaceae/genetics, Bacteroidaceae Infections/complications, Chronic Disease, Coronary Disease/epidemiology, DNA, Bacterial/genetics, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Periodontitis/complications, Periodontium/microbiology, Prevalence, Retrospective Studies, Risk Factors",
author = "Axel Spahr and Elena Klein and Natalie Khuseyinova and Clemens Boeckh and Rainer Muche and Markus Kunze and Dietrich Rothenbacher and Gita Pezeshki and Albrecht Hoffmeister and Wolfgang Koenig",
year = "2006",
month = mar,
day = "13",
doi = "10.1001/archinte.166.5.554",
language = "English",
volume = "166",
pages = "554--559",
journal = "JAMA INTERN MED",
issn = "2168-6106",
publisher = "American Medical Association",
number = "5",

}

RIS

TY - JOUR

T1 - Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study

AU - Spahr, Axel

AU - Klein, Elena

AU - Khuseyinova, Natalie

AU - Boeckh, Clemens

AU - Muche, Rainer

AU - Kunze, Markus

AU - Rothenbacher, Dietrich

AU - Pezeshki, Gita

AU - Hoffmeister, Albrecht

AU - Koenig, Wolfgang

PY - 2006/3/13

Y1 - 2006/3/13

N2 - BACKGROUND: Chronic inflammation from any source is associated with increased cardiovascular risk. Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects.METHODS: A total of 789 subjects (263 patients with angiographically confirmed, stable CHD and 526 population-based, age- and sex-matched controls without a history of CHD) were included in the Coronary Event and Periodontal Disease (CORODONT) study. Subgingival biofilm samples were analyzed for periodontal pathogens Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Porphyromonas gingivalis, Prevotella intermedia, and Treponema denticola using DNA-DNA hybridization. The need for periodontal treatment in each subject was assessed using the Community Periodontal Index of Treatment Needs (CPITN). The main outcome measures included total periodontal pathogen burden, number of the various periodontal pathogens in the subgingival biofilm, and periodontal treatment needs (according to the CPITN).RESULTS: In multivariable analyses, we found a statistically significant association between the periodontal pathogen burden (log10 of the sum of all pathogens) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.34-2.74; P<.001) or the number of A actinomycetemcomitans in periodontal pockets (log10) (OR, 2.70; 95% CI, 1.79-4.07; P<.001) and the presence of CHD. In addition, a statistically significant association between an increase in mean CPITN score by 1 and the presence of CHD (OR, 1.67; 95% CI, 1.08-2.58; P = .02) was observed.CONCLUSIONS: Our findings suggest an association between periodontitis and presence of CHD. Periodontal pathogen burden, and particularly infection with A actinomycetemcomitans, may be of special importance.

AB - BACKGROUND: Chronic inflammation from any source is associated with increased cardiovascular risk. Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects.METHODS: A total of 789 subjects (263 patients with angiographically confirmed, stable CHD and 526 population-based, age- and sex-matched controls without a history of CHD) were included in the Coronary Event and Periodontal Disease (CORODONT) study. Subgingival biofilm samples were analyzed for periodontal pathogens Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Porphyromonas gingivalis, Prevotella intermedia, and Treponema denticola using DNA-DNA hybridization. The need for periodontal treatment in each subject was assessed using the Community Periodontal Index of Treatment Needs (CPITN). The main outcome measures included total periodontal pathogen burden, number of the various periodontal pathogens in the subgingival biofilm, and periodontal treatment needs (according to the CPITN).RESULTS: In multivariable analyses, we found a statistically significant association between the periodontal pathogen burden (log10 of the sum of all pathogens) (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.34-2.74; P<.001) or the number of A actinomycetemcomitans in periodontal pockets (log10) (OR, 2.70; 95% CI, 1.79-4.07; P<.001) and the presence of CHD. In addition, a statistically significant association between an increase in mean CPITN score by 1 and the presence of CHD (OR, 1.67; 95% CI, 1.08-2.58; P = .02) was observed.CONCLUSIONS: Our findings suggest an association between periodontitis and presence of CHD. Periodontal pathogen burden, and particularly infection with A actinomycetemcomitans, may be of special importance.

KW - Adult

KW - Aged

KW - Bacteroidaceae/genetics

KW - Bacteroidaceae Infections/complications

KW - Chronic Disease

KW - Coronary Disease/epidemiology

KW - DNA, Bacterial/genetics

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Periodontitis/complications

KW - Periodontium/microbiology

KW - Prevalence

KW - Retrospective Studies

KW - Risk Factors

U2 - 10.1001/archinte.166.5.554

DO - 10.1001/archinte.166.5.554

M3 - SCORING: Journal article

C2 - 16534043

VL - 166

SP - 554

EP - 559

JO - JAMA INTERN MED

JF - JAMA INTERN MED

SN - 2168-6106

IS - 5

ER -