Perimortem fixation of the gastric and duodenal mucosa: a diagnostic indication for oral poisoning.
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Perimortem fixation of the gastric and duodenal mucosa: a diagnostic indication for oral poisoning. / Sperhake, Jan; Tsokos, M; Sperhake, K.
In: INT J LEGAL MED, Vol. 112, No. 5, 5, 1999, p. 317-320.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Perimortem fixation of the gastric and duodenal mucosa: a diagnostic indication for oral poisoning.
AU - Sperhake, Jan
AU - Tsokos, M
AU - Sperhake, K
PY - 1999
Y1 - 1999
N2 - Two cases of fatal oral poisoning are presented. In the first case, a 40-year-old man died due to a lethal dose of mercury (blood concentration 113.8 microg/ml) and in the second, a 34-year-old man died of chloralhydrate overdose with a lethal blood concentration of trichloroethanol (52 microg/ml), the active metabolite of chloralhydrate. In both cases gross examination and histology showed an unusually well preserved gastrointestinal mucosa in addition to unspecific signs of intoxication. The two cases demonstrate that the phenomenon of perimortal fixation is a useful indication for the forensic pathologist and should direct the suspicion to oral poisoning. The detection of fixation facilitates toxicology screening by indicating that the relevant substance must have the capability to precipitate proteins.
AB - Two cases of fatal oral poisoning are presented. In the first case, a 40-year-old man died due to a lethal dose of mercury (blood concentration 113.8 microg/ml) and in the second, a 34-year-old man died of chloralhydrate overdose with a lethal blood concentration of trichloroethanol (52 microg/ml), the active metabolite of chloralhydrate. In both cases gross examination and histology showed an unusually well preserved gastrointestinal mucosa in addition to unspecific signs of intoxication. The two cases demonstrate that the phenomenon of perimortal fixation is a useful indication for the forensic pathologist and should direct the suspicion to oral poisoning. The detection of fixation facilitates toxicology screening by indicating that the relevant substance must have the capability to precipitate proteins.
M3 - SCORING: Zeitschriftenaufsatz
VL - 112
SP - 317
EP - 320
JO - INT J LEGAL MED
JF - INT J LEGAL MED
SN - 0937-9827
IS - 5
M1 - 5
ER -
