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Perihematomal Edema and Clinical Outcome in Intracerebral Hemorrhage Related to Different Oral Anticoagulants

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Perihematomal Edema and Clinical Outcome in Intracerebral Hemorrhage Related to Different Oral Anticoagulants. / Nawabi, Jawed; Elsayed, Sarah; Morotti, Andrea; Speth, Anna; Liu, Melanie; Kniep, Helge; McDonough, Rosalie; Broocks, Gabriel; Faizy, Tobias; Can, Elif; Sporns, Peter B; Fiehler, Jens; Hamm, Bernd; Penzkofer, Tobias; Bohner, Georg; Schlunk, Frieder; Hanning, Uta.

In: J CLIN MED, Vol. 10, No. 11, 2234, 21.05.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nawabi, J, Elsayed, S, Morotti, A, Speth, A, Liu, M, Kniep, H, McDonough, R, Broocks, G, Faizy, T, Can, E, Sporns, PB, Fiehler, J, Hamm, B, Penzkofer, T, Bohner, G, Schlunk, F & Hanning, U 2021, 'Perihematomal Edema and Clinical Outcome in Intracerebral Hemorrhage Related to Different Oral Anticoagulants', J CLIN MED, vol. 10, no. 11, 2234. https://doi.org/10.3390/jcm10112234

APA

Nawabi, J., Elsayed, S., Morotti, A., Speth, A., Liu, M., Kniep, H., McDonough, R., Broocks, G., Faizy, T., Can, E., Sporns, P. B., Fiehler, J., Hamm, B., Penzkofer, T., Bohner, G., Schlunk, F., & Hanning, U. (2021). Perihematomal Edema and Clinical Outcome in Intracerebral Hemorrhage Related to Different Oral Anticoagulants. J CLIN MED, 10(11), [2234]. https://doi.org/10.3390/jcm10112234

Vancouver

Nawabi J, Elsayed S, Morotti A, Speth A, Liu M, Kniep H et al. Perihematomal Edema and Clinical Outcome in Intracerebral Hemorrhage Related to Different Oral Anticoagulants. J CLIN MED. 2021 May 21;10(11). 2234. https://doi.org/10.3390/jcm10112234

Bibtex

@article{576b0ab7f48f42c68f4668d1d23b5e65,
title = "Perihematomal Edema and Clinical Outcome in Intracerebral Hemorrhage Related to Different Oral Anticoagulants",
abstract = "BACKGROUND: There is a need to examine the effects of different types of oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) on perihematomal edema (PHE), which is gaining considerable appeal as a biomarker for secondary brain injury and clinical outcome.METHODS: In a large multicenter approach, computed tomography-derived imaging markers for PHE (absolute PHE, relative PHE (rPHE), edema expansion distance (EED)) were calculated for patients with OAC-ICH and NON-OAC-ICH. Exploratory analysis for non-vitamin-K-antagonist OAC (NOAC) and vitamin-K-antagonists (VKA) was performed. The predictive performance of logistic regression models, employing predictors of poor functional outcome (modified Rankin scale 4-6), was explored.RESULTS: Of 811 retrospectively enrolled patients, 212 (26.14%) had an OAC-ICH. Mean rPHE and mean EED were significantly lower in patients with OAC-ICH compared to NON-OAC-ICH, p-value 0.001 and 0.007; whereas, mean absolute PHE did not differ, p-value 0.091. Mean EED was also significantly lower in NOAC compared to NON-OAC-ICH, p-value 0.05. Absolute PHE was an independent predictor of poor clinical outcome in NON-OAC-ICH (OR 1.02; 95%CI 1.002-1.028; p-value 0.027), but not in OAC-ICH (p-value 0.45).CONCLUSION: Quantitative markers of early PHE (rPHE and EED) were lower in patients with OAC-ICH compared to those with NON-OAC-ICH, with significantly lower levels of EED in NOAC compared to NON-OAC-ICH. Increase of early PHE volume did not increase the likelihood of poor outcome in OAC-ICH, but was independently associated with poor outcome in NON-OAC-ICH. The results underline the importance of etiology-specific treatment strategies. Further prospective studies are needed.",
author = "Jawed Nawabi and Sarah Elsayed and Andrea Morotti and Anna Speth and Melanie Liu and Helge Kniep and Rosalie McDonough and Gabriel Broocks and Tobias Faizy and Elif Can and Sporns, {Peter B} and Jens Fiehler and Bernd Hamm and Tobias Penzkofer and Georg Bohner and Frieder Schlunk and Uta Hanning",
year = "2021",
month = may,
day = "21",
doi = "10.3390/jcm10112234",
language = "English",
volume = "10",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "11",

}

RIS

TY - JOUR

T1 - Perihematomal Edema and Clinical Outcome in Intracerebral Hemorrhage Related to Different Oral Anticoagulants

AU - Nawabi, Jawed

AU - Elsayed, Sarah

AU - Morotti, Andrea

AU - Speth, Anna

AU - Liu, Melanie

AU - Kniep, Helge

AU - McDonough, Rosalie

AU - Broocks, Gabriel

AU - Faizy, Tobias

AU - Can, Elif

AU - Sporns, Peter B

AU - Fiehler, Jens

AU - Hamm, Bernd

AU - Penzkofer, Tobias

AU - Bohner, Georg

AU - Schlunk, Frieder

AU - Hanning, Uta

PY - 2021/5/21

Y1 - 2021/5/21

N2 - BACKGROUND: There is a need to examine the effects of different types of oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) on perihematomal edema (PHE), which is gaining considerable appeal as a biomarker for secondary brain injury and clinical outcome.METHODS: In a large multicenter approach, computed tomography-derived imaging markers for PHE (absolute PHE, relative PHE (rPHE), edema expansion distance (EED)) were calculated for patients with OAC-ICH and NON-OAC-ICH. Exploratory analysis for non-vitamin-K-antagonist OAC (NOAC) and vitamin-K-antagonists (VKA) was performed. The predictive performance of logistic regression models, employing predictors of poor functional outcome (modified Rankin scale 4-6), was explored.RESULTS: Of 811 retrospectively enrolled patients, 212 (26.14%) had an OAC-ICH. Mean rPHE and mean EED were significantly lower in patients with OAC-ICH compared to NON-OAC-ICH, p-value 0.001 and 0.007; whereas, mean absolute PHE did not differ, p-value 0.091. Mean EED was also significantly lower in NOAC compared to NON-OAC-ICH, p-value 0.05. Absolute PHE was an independent predictor of poor clinical outcome in NON-OAC-ICH (OR 1.02; 95%CI 1.002-1.028; p-value 0.027), but not in OAC-ICH (p-value 0.45).CONCLUSION: Quantitative markers of early PHE (rPHE and EED) were lower in patients with OAC-ICH compared to those with NON-OAC-ICH, with significantly lower levels of EED in NOAC compared to NON-OAC-ICH. Increase of early PHE volume did not increase the likelihood of poor outcome in OAC-ICH, but was independently associated with poor outcome in NON-OAC-ICH. The results underline the importance of etiology-specific treatment strategies. Further prospective studies are needed.

AB - BACKGROUND: There is a need to examine the effects of different types of oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) on perihematomal edema (PHE), which is gaining considerable appeal as a biomarker for secondary brain injury and clinical outcome.METHODS: In a large multicenter approach, computed tomography-derived imaging markers for PHE (absolute PHE, relative PHE (rPHE), edema expansion distance (EED)) were calculated for patients with OAC-ICH and NON-OAC-ICH. Exploratory analysis for non-vitamin-K-antagonist OAC (NOAC) and vitamin-K-antagonists (VKA) was performed. The predictive performance of logistic regression models, employing predictors of poor functional outcome (modified Rankin scale 4-6), was explored.RESULTS: Of 811 retrospectively enrolled patients, 212 (26.14%) had an OAC-ICH. Mean rPHE and mean EED were significantly lower in patients with OAC-ICH compared to NON-OAC-ICH, p-value 0.001 and 0.007; whereas, mean absolute PHE did not differ, p-value 0.091. Mean EED was also significantly lower in NOAC compared to NON-OAC-ICH, p-value 0.05. Absolute PHE was an independent predictor of poor clinical outcome in NON-OAC-ICH (OR 1.02; 95%CI 1.002-1.028; p-value 0.027), but not in OAC-ICH (p-value 0.45).CONCLUSION: Quantitative markers of early PHE (rPHE and EED) were lower in patients with OAC-ICH compared to those with NON-OAC-ICH, with significantly lower levels of EED in NOAC compared to NON-OAC-ICH. Increase of early PHE volume did not increase the likelihood of poor outcome in OAC-ICH, but was independently associated with poor outcome in NON-OAC-ICH. The results underline the importance of etiology-specific treatment strategies. Further prospective studies are needed.

U2 - 10.3390/jcm10112234

DO - 10.3390/jcm10112234

M3 - SCORING: Journal article

C2 - 34063991

VL - 10

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 11

M1 - 2234

ER -