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Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis

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Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis. / Dengler, Julius; Maldaner, Nicolai; Bijlenga, Philippe; Burkhardt, Jan-Karl; Graewe, Alexander; Guhl, Susanne; Hong, Bujung; Hohaus, Christian; Kursumovic, Adisa; Mielke, Dorothee; Schebesch, Karl-Michael; Wostrack, Maria; Rufenacht, Daniel; Vajkoczy, Peter; Schmidt, Nils Ole; Giant Intracranial Aneurysm Registry Study Group.

In: J NEUROSURG, Vol. 123, No. 2, 17.04.2015, p. 446-452.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dengler, J, Maldaner, N, Bijlenga, P, Burkhardt, J-K, Graewe, A, Guhl, S, Hong, B, Hohaus, C, Kursumovic, A, Mielke, D, Schebesch, K-M, Wostrack, M, Rufenacht, D, Vajkoczy, P, Schmidt, NO & Giant Intracranial Aneurysm Registry Study Group 2015, 'Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis', J NEUROSURG, vol. 123, no. 2, pp. 446-452. https://doi.org/10.3171/2014.10.JNS141560

APA

Dengler, J., Maldaner, N., Bijlenga, P., Burkhardt, J-K., Graewe, A., Guhl, S., Hong, B., Hohaus, C., Kursumovic, A., Mielke, D., Schebesch, K-M., Wostrack, M., Rufenacht, D., Vajkoczy, P., Schmidt, N. O., & Giant Intracranial Aneurysm Registry Study Group (2015). Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis. J NEUROSURG, 123(2), 446-452. https://doi.org/10.3171/2014.10.JNS141560

Vancouver

Dengler J, Maldaner N, Bijlenga P, Burkhardt J-K, Graewe A, Guhl S et al. Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis. J NEUROSURG. 2015 Apr 17;123(2):446-452. https://doi.org/10.3171/2014.10.JNS141560

Bibtex

@article{f9a794aceb944147a5328df657047190,
title = "Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis",
abstract = "OBJECT The underlying mechanisms causing intracranial perianeurysmal edema (PAE) are still poorly understood. Since PAE is most frequently observed in giant intracranial aneurysms (GIAs), the authors designed a study to examine the occurrence of PAE in relation to the location, size, and partial thrombosis (PT) of GIAs along with the clinical impact of PAE. METHODS Magnetic resonance imaging data for patients with a diagnosis of unruptured GIA from the international multicenter Giant Intracranial Aneurysm Registry were retrospectively analyzed with regard to location and size of the GIA, PAE volume, and the presence of PT. The occurrence of PAE was correlated to clinical findings. RESULTS Imaging data for 69 GIAs were eligible for inclusion in this study. Perianeurysmal edema was observed in 33.3% of all cases, with the highest frequency in GIAs of the middle cerebral artery (MCA; 68.8%) and the lowest frequency in GIAs of the cavernous internal carotid artery (ICA; 0.0%). Independent predictors of PAE formation were GIA volume (OR 1.13, p = 0.02) and the occurrence of PT (OR 9.84, p = 0.04). Giant intracranial aneurysm location did not predict PAE occurrence. Giant aneurysms with PAE were larger than GIAs without PAE (p < 0.01), and GIA volume correlated with PAE volume (rs = 0.51, p = 0.01). Perianeurysmal edema had no influence on the modified Rankin Scale score (p = 0.30 or the occurrence of aphasia (p = 0.61) or hemiparesis (p = 0.82). CONCLUSIONS Perianeurysmal edema was associated with GIA size and the presence of PT. As no PAE was observed in cavernous ICA aneurysms, even though they exerted mass effect on the brain and also displayed PT, the dura mater may serve as a barrier protecting the brain from PAE formation.",
author = "Julius Dengler and Nicolai Maldaner and Philippe Bijlenga and Jan-Karl Burkhardt and Alexander Graewe and Susanne Guhl and Bujung Hong and Christian Hohaus and Adisa Kursumovic and Dorothee Mielke and Karl-Michael Schebesch and Maria Wostrack and Daniel Rufenacht and Peter Vajkoczy and Schmidt, {Nils Ole} and {Giant Intracranial Aneurysm Registry Study Group}",
year = "2015",
month = apr,
day = "17",
doi = "10.3171/2014.10.JNS141560",
language = "English",
volume = "123",
pages = "446--452",
journal = "J NEUROSURG",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "2",

}

RIS

TY - JOUR

T1 - Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis

AU - Dengler, Julius

AU - Maldaner, Nicolai

AU - Bijlenga, Philippe

AU - Burkhardt, Jan-Karl

AU - Graewe, Alexander

AU - Guhl, Susanne

AU - Hong, Bujung

AU - Hohaus, Christian

AU - Kursumovic, Adisa

AU - Mielke, Dorothee

AU - Schebesch, Karl-Michael

AU - Wostrack, Maria

AU - Rufenacht, Daniel

AU - Vajkoczy, Peter

AU - Schmidt, Nils Ole

AU - Giant Intracranial Aneurysm Registry Study Group

PY - 2015/4/17

Y1 - 2015/4/17

N2 - OBJECT The underlying mechanisms causing intracranial perianeurysmal edema (PAE) are still poorly understood. Since PAE is most frequently observed in giant intracranial aneurysms (GIAs), the authors designed a study to examine the occurrence of PAE in relation to the location, size, and partial thrombosis (PT) of GIAs along with the clinical impact of PAE. METHODS Magnetic resonance imaging data for patients with a diagnosis of unruptured GIA from the international multicenter Giant Intracranial Aneurysm Registry were retrospectively analyzed with regard to location and size of the GIA, PAE volume, and the presence of PT. The occurrence of PAE was correlated to clinical findings. RESULTS Imaging data for 69 GIAs were eligible for inclusion in this study. Perianeurysmal edema was observed in 33.3% of all cases, with the highest frequency in GIAs of the middle cerebral artery (MCA; 68.8%) and the lowest frequency in GIAs of the cavernous internal carotid artery (ICA; 0.0%). Independent predictors of PAE formation were GIA volume (OR 1.13, p = 0.02) and the occurrence of PT (OR 9.84, p = 0.04). Giant intracranial aneurysm location did not predict PAE occurrence. Giant aneurysms with PAE were larger than GIAs without PAE (p < 0.01), and GIA volume correlated with PAE volume (rs = 0.51, p = 0.01). Perianeurysmal edema had no influence on the modified Rankin Scale score (p = 0.30 or the occurrence of aphasia (p = 0.61) or hemiparesis (p = 0.82). CONCLUSIONS Perianeurysmal edema was associated with GIA size and the presence of PT. As no PAE was observed in cavernous ICA aneurysms, even though they exerted mass effect on the brain and also displayed PT, the dura mater may serve as a barrier protecting the brain from PAE formation.

AB - OBJECT The underlying mechanisms causing intracranial perianeurysmal edema (PAE) are still poorly understood. Since PAE is most frequently observed in giant intracranial aneurysms (GIAs), the authors designed a study to examine the occurrence of PAE in relation to the location, size, and partial thrombosis (PT) of GIAs along with the clinical impact of PAE. METHODS Magnetic resonance imaging data for patients with a diagnosis of unruptured GIA from the international multicenter Giant Intracranial Aneurysm Registry were retrospectively analyzed with regard to location and size of the GIA, PAE volume, and the presence of PT. The occurrence of PAE was correlated to clinical findings. RESULTS Imaging data for 69 GIAs were eligible for inclusion in this study. Perianeurysmal edema was observed in 33.3% of all cases, with the highest frequency in GIAs of the middle cerebral artery (MCA; 68.8%) and the lowest frequency in GIAs of the cavernous internal carotid artery (ICA; 0.0%). Independent predictors of PAE formation were GIA volume (OR 1.13, p = 0.02) and the occurrence of PT (OR 9.84, p = 0.04). Giant intracranial aneurysm location did not predict PAE occurrence. Giant aneurysms with PAE were larger than GIAs without PAE (p < 0.01), and GIA volume correlated with PAE volume (rs = 0.51, p = 0.01). Perianeurysmal edema had no influence on the modified Rankin Scale score (p = 0.30 or the occurrence of aphasia (p = 0.61) or hemiparesis (p = 0.82). CONCLUSIONS Perianeurysmal edema was associated with GIA size and the presence of PT. As no PAE was observed in cavernous ICA aneurysms, even though they exerted mass effect on the brain and also displayed PT, the dura mater may serve as a barrier protecting the brain from PAE formation.

U2 - 10.3171/2014.10.JNS141560

DO - 10.3171/2014.10.JNS141560

M3 - SCORING: Journal article

C2 - 25884259

VL - 123

SP - 446

EP - 452

JO - J NEUROSURG

JF - J NEUROSURG

SN - 0022-3085

IS - 2

ER -