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Perfusion MRI of U87 brain tumors in a mouse model.

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Perfusion MRI of U87 brain tumors in a mouse model. / Sun, Yanping; Schmidt, Nils-Ole; Schmidt, Karl; Doshi, Sameer; Rubin, Joshua B; Mulkern, Robert V; Carroll, Rona; Ziu, Mateo; Erkmen, Kadir; Poussaint, Tina Y; Black, Peter; Albert, Mitchell; Burstein, Deborah; Kieran, Mark W.

In: MAGN RESON MED, Vol. 51, No. 5, 5, 2004, p. 893-899.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sun, Y, Schmidt, N-O, Schmidt, K, Doshi, S, Rubin, JB, Mulkern, RV, Carroll, R, Ziu, M, Erkmen, K, Poussaint, TY, Black, P, Albert, M, Burstein, D & Kieran, MW 2004, 'Perfusion MRI of U87 brain tumors in a mouse model.', MAGN RESON MED, vol. 51, no. 5, 5, pp. 893-899. <http://www.ncbi.nlm.nih.gov/pubmed/15122670?dopt=Citation>

APA

Sun, Y., Schmidt, N-O., Schmidt, K., Doshi, S., Rubin, J. B., Mulkern, R. V., Carroll, R., Ziu, M., Erkmen, K., Poussaint, T. Y., Black, P., Albert, M., Burstein, D., & Kieran, M. W. (2004). Perfusion MRI of U87 brain tumors in a mouse model. MAGN RESON MED, 51(5), 893-899. [5]. http://www.ncbi.nlm.nih.gov/pubmed/15122670?dopt=Citation

Vancouver

Sun Y, Schmidt N-O, Schmidt K, Doshi S, Rubin JB, Mulkern RV et al. Perfusion MRI of U87 brain tumors in a mouse model. MAGN RESON MED. 2004;51(5):893-899. 5.

Bibtex

@article{b749dfaf4fea447db7624e1c22b24aa3,
title = "Perfusion MRI of U87 brain tumors in a mouse model.",
abstract = "Continuous arterial spin labeling (CASL) was used to obtain an index of cerebral blood flow (ICBF) in the normal mouse brain and in an orthotopic mouse model of human U87 high-grade glioma at 8.5 T. Under the assumption of a constant tissue:blood partition coefficient for water in different tissues, the mean ICBF (n = 14) was found to be 50 +/- 9 mL/100g/min for tumor core and 209 +/- 11 mL/100g/min for normal tissue. The apparent T(1) (T(1app)) was 2.01 +/- 0.06 sec for tumor core and 1.66 +/- 0.03 sec for normal tissue. The ICBF and the T(1app) values were significantly different (P <0.001) between these two regions. The detailed changes of ICBF and T(1app) in the transition from the tumor core through the tumor periphery to surrounding tissue were studied. Immunohistochemistry indicated that tumor vascularity was not uniform, with microvessel density highest in normal brain and the tissue surrounding the tumor and lowest in the tumor core. The large difference in ICBF between the tumor core and normal tissue suggests that this index might be useful for the assessment of the efficacy of antiangiogenic therapy.",
author = "Yanping Sun and Nils-Ole Schmidt and Karl Schmidt and Sameer Doshi and Rubin, {Joshua B} and Mulkern, {Robert V} and Rona Carroll and Mateo Ziu and Kadir Erkmen and Poussaint, {Tina Y} and Peter Black and Mitchell Albert and Deborah Burstein and Kieran, {Mark W}",
year = "2004",
language = "Deutsch",
volume = "51",
pages = "893--899",
journal = "MAGN RESON MED",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Perfusion MRI of U87 brain tumors in a mouse model.

AU - Sun, Yanping

AU - Schmidt, Nils-Ole

AU - Schmidt, Karl

AU - Doshi, Sameer

AU - Rubin, Joshua B

AU - Mulkern, Robert V

AU - Carroll, Rona

AU - Ziu, Mateo

AU - Erkmen, Kadir

AU - Poussaint, Tina Y

AU - Black, Peter

AU - Albert, Mitchell

AU - Burstein, Deborah

AU - Kieran, Mark W

PY - 2004

Y1 - 2004

N2 - Continuous arterial spin labeling (CASL) was used to obtain an index of cerebral blood flow (ICBF) in the normal mouse brain and in an orthotopic mouse model of human U87 high-grade glioma at 8.5 T. Under the assumption of a constant tissue:blood partition coefficient for water in different tissues, the mean ICBF (n = 14) was found to be 50 +/- 9 mL/100g/min for tumor core and 209 +/- 11 mL/100g/min for normal tissue. The apparent T(1) (T(1app)) was 2.01 +/- 0.06 sec for tumor core and 1.66 +/- 0.03 sec for normal tissue. The ICBF and the T(1app) values were significantly different (P <0.001) between these two regions. The detailed changes of ICBF and T(1app) in the transition from the tumor core through the tumor periphery to surrounding tissue were studied. Immunohistochemistry indicated that tumor vascularity was not uniform, with microvessel density highest in normal brain and the tissue surrounding the tumor and lowest in the tumor core. The large difference in ICBF between the tumor core and normal tissue suggests that this index might be useful for the assessment of the efficacy of antiangiogenic therapy.

AB - Continuous arterial spin labeling (CASL) was used to obtain an index of cerebral blood flow (ICBF) in the normal mouse brain and in an orthotopic mouse model of human U87 high-grade glioma at 8.5 T. Under the assumption of a constant tissue:blood partition coefficient for water in different tissues, the mean ICBF (n = 14) was found to be 50 +/- 9 mL/100g/min for tumor core and 209 +/- 11 mL/100g/min for normal tissue. The apparent T(1) (T(1app)) was 2.01 +/- 0.06 sec for tumor core and 1.66 +/- 0.03 sec for normal tissue. The ICBF and the T(1app) values were significantly different (P <0.001) between these two regions. The detailed changes of ICBF and T(1app) in the transition from the tumor core through the tumor periphery to surrounding tissue were studied. Immunohistochemistry indicated that tumor vascularity was not uniform, with microvessel density highest in normal brain and the tissue surrounding the tumor and lowest in the tumor core. The large difference in ICBF between the tumor core and normal tissue suggests that this index might be useful for the assessment of the efficacy of antiangiogenic therapy.

M3 - SCORING: Zeitschriftenaufsatz

VL - 51

SP - 893

EP - 899

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 5

M1 - 5

ER -