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Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion

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Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion. / Faizy, Tobias D; Kabiri, Reza; Christensen, Soren; Mlynash, Michael; Kuraitis, Gabriella; Broocks, Gabriel; Hanning, Uta; Nawabi, Jawed; Lansberg, Maarten G; Marks, Michael P; Albers, Gregory W; Fiehler, Jens; Wintermark, Max; Heit, Jeremy J.

In: J CEREBR BLOOD F MET, Vol. 41, No. 8, 01.08.2021, p. 2067-2075.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Faizy, TD, Kabiri, R, Christensen, S, Mlynash, M, Kuraitis, G, Broocks, G, Hanning, U, Nawabi, J, Lansberg, MG, Marks, MP, Albers, GW, Fiehler, J, Wintermark, M & Heit, JJ 2021, 'Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion', J CEREBR BLOOD F MET, vol. 41, no. 8, pp. 2067-2075. https://doi.org/10.1177/0271678X21992200

APA

Faizy, T. D., Kabiri, R., Christensen, S., Mlynash, M., Kuraitis, G., Broocks, G., Hanning, U., Nawabi, J., Lansberg, M. G., Marks, M. P., Albers, G. W., Fiehler, J., Wintermark, M., & Heit, J. J. (2021). Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion. J CEREBR BLOOD F MET, 41(8), 2067-2075. https://doi.org/10.1177/0271678X21992200

Vancouver

Faizy TD, Kabiri R, Christensen S, Mlynash M, Kuraitis G, Broocks G et al. Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion. J CEREBR BLOOD F MET. 2021 Aug 1;41(8):2067-2075. https://doi.org/10.1177/0271678X21992200

Bibtex

@article{76b43ec4726646d18ecd5d30ae7d2fb8,
title = "Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion",
abstract = "Ischemic lesion Net Water Uptake (NWU) quantifies cerebral edema formation and likely correlates with the microvascular perfusion status of patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). We hypothesized that favorable tissue-level collaterals (TLC) predict less NWU and good functional outcomes. We performed a retrospective multicenter analysis of AIS-LVO patients who underwent thrombectomy triage. TLC were measured on cerebral perfusion studies using the hypoperfusion intensity ratio (HIR; volume ratio of brain tissue with [Tmax > 10 sec/Tmax > 6 sec]); favorable TLC were regarded as HIR ≤ 0.4. NWU was determined using a quantitative densitometry approach on follow-up CT. Primary outcome was NWU. Secondary outcome was a good functional outcome (modified Rankin Scale [mRS] 0-2).580 patients met inclusion criteria. Favorable TLC (β: 4.23, SE: 0.65; p < 0.001) predicted smaller NWU after treatment. Favorable TLC (OR: 2.35, [95% CI: 1.31-4.21]; p < 0.001), and decreased NWU (OR: 0.75, [95% CI: 0.70-0.79]; p < 0.001) predicted good functional outcome, while controlling for age, glucose, CTA collaterals, baseline NIHSS and good vessel reperfusion status.We conclude that favorable TLC predict less ischemic lesion NWU after treatment in AIS-LVO patients. Favorable TLC and decreased NWU were independent predictors of good functional outcome.",
keywords = "Acute Disease, Aged, Aged, 80 and over, Brain/blood supply, Collateral Circulation, Female, Humans, Ischemic Stroke/diagnostic imaging, Logistic Models, Magnetic Resonance Imaging, Male, Middle Aged, Odds Ratio, Perfusion Imaging/methods, Retrospective Studies, Thrombectomy, Tissue Plasminogen Activator/therapeutic use, Tomography, X-Ray Computed",
author = "Faizy, {Tobias D} and Reza Kabiri and Soren Christensen and Michael Mlynash and Gabriella Kuraitis and Gabriel Broocks and Uta Hanning and Jawed Nawabi and Lansberg, {Maarten G} and Marks, {Michael P} and Albers, {Gregory W} and Jens Fiehler and Max Wintermark and Heit, {Jeremy J}",
year = "2021",
month = aug,
day = "1",
doi = "10.1177/0271678X21992200",
language = "English",
volume = "41",
pages = "2067--2075",
journal = "J CEREBR BLOOD F MET",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "8",

}

RIS

TY - JOUR

T1 - Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion

AU - Faizy, Tobias D

AU - Kabiri, Reza

AU - Christensen, Soren

AU - Mlynash, Michael

AU - Kuraitis, Gabriella

AU - Broocks, Gabriel

AU - Hanning, Uta

AU - Nawabi, Jawed

AU - Lansberg, Maarten G

AU - Marks, Michael P

AU - Albers, Gregory W

AU - Fiehler, Jens

AU - Wintermark, Max

AU - Heit, Jeremy J

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Ischemic lesion Net Water Uptake (NWU) quantifies cerebral edema formation and likely correlates with the microvascular perfusion status of patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). We hypothesized that favorable tissue-level collaterals (TLC) predict less NWU and good functional outcomes. We performed a retrospective multicenter analysis of AIS-LVO patients who underwent thrombectomy triage. TLC were measured on cerebral perfusion studies using the hypoperfusion intensity ratio (HIR; volume ratio of brain tissue with [Tmax > 10 sec/Tmax > 6 sec]); favorable TLC were regarded as HIR ≤ 0.4. NWU was determined using a quantitative densitometry approach on follow-up CT. Primary outcome was NWU. Secondary outcome was a good functional outcome (modified Rankin Scale [mRS] 0-2).580 patients met inclusion criteria. Favorable TLC (β: 4.23, SE: 0.65; p < 0.001) predicted smaller NWU after treatment. Favorable TLC (OR: 2.35, [95% CI: 1.31-4.21]; p < 0.001), and decreased NWU (OR: 0.75, [95% CI: 0.70-0.79]; p < 0.001) predicted good functional outcome, while controlling for age, glucose, CTA collaterals, baseline NIHSS and good vessel reperfusion status.We conclude that favorable TLC predict less ischemic lesion NWU after treatment in AIS-LVO patients. Favorable TLC and decreased NWU were independent predictors of good functional outcome.

AB - Ischemic lesion Net Water Uptake (NWU) quantifies cerebral edema formation and likely correlates with the microvascular perfusion status of patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). We hypothesized that favorable tissue-level collaterals (TLC) predict less NWU and good functional outcomes. We performed a retrospective multicenter analysis of AIS-LVO patients who underwent thrombectomy triage. TLC were measured on cerebral perfusion studies using the hypoperfusion intensity ratio (HIR; volume ratio of brain tissue with [Tmax > 10 sec/Tmax > 6 sec]); favorable TLC were regarded as HIR ≤ 0.4. NWU was determined using a quantitative densitometry approach on follow-up CT. Primary outcome was NWU. Secondary outcome was a good functional outcome (modified Rankin Scale [mRS] 0-2).580 patients met inclusion criteria. Favorable TLC (β: 4.23, SE: 0.65; p < 0.001) predicted smaller NWU after treatment. Favorable TLC (OR: 2.35, [95% CI: 1.31-4.21]; p < 0.001), and decreased NWU (OR: 0.75, [95% CI: 0.70-0.79]; p < 0.001) predicted good functional outcome, while controlling for age, glucose, CTA collaterals, baseline NIHSS and good vessel reperfusion status.We conclude that favorable TLC predict less ischemic lesion NWU after treatment in AIS-LVO patients. Favorable TLC and decreased NWU were independent predictors of good functional outcome.

KW - Acute Disease

KW - Aged

KW - Aged, 80 and over

KW - Brain/blood supply

KW - Collateral Circulation

KW - Female

KW - Humans

KW - Ischemic Stroke/diagnostic imaging

KW - Logistic Models

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Perfusion Imaging/methods

KW - Retrospective Studies

KW - Thrombectomy

KW - Tissue Plasminogen Activator/therapeutic use

KW - Tomography, X-Ray Computed

U2 - 10.1177/0271678X21992200

DO - 10.1177/0271678X21992200

M3 - SCORING: Journal article

C2 - 33557694

VL - 41

SP - 2067

EP - 2075

JO - J CEREBR BLOOD F MET

JF - J CEREBR BLOOD F MET

SN - 0271-678X

IS - 8

ER -