Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis

Hermann Faller; Elmar Brähler; Martin Härter; Monika Keller; Holger Schulz; Karl Wegscheider; Joachim Weis; Anna Boehncke; Matthias Richard; Susanne Sehner; Uwe Koch; Anja Mehnert

doi:10.1002/pon.3811

Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis

Standard

Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis. / Faller, Hermann; Brähler, Elmar; Härter, Martin; Keller, Monika; Schulz, Holger ; Wegscheider, Karl; Weis, Joachim; Boehncke, Anna; Richard, Matthias; Sehner, Susanne ; Koch, Uwe; Mehnert, Anja.

In: PSYCHO-ONCOLOGY, Vol. 24, No. 11, 11.2015, p. 1456-1462.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Faller, H, Brähler, E, Härter, M, Keller, M, Schulz, H , Wegscheider, K, Weis, J, Boehncke, A, Richard, M, Sehner, S , Koch, U & Mehnert, A 2015, 'Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis', PSYCHO-ONCOLOGY, vol. 24, no. 11, pp. 1456-1462. https://doi.org/10.1002/pon.3811

APA

Faller, H., Brähler, E., Härter, M., Keller, M., Schulz, H., Wegscheider, K., Weis, J., Boehncke, A., Richard, M., Sehner, S., Koch, U., & Mehnert, A. (2015). Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis. PSYCHO-ONCOLOGY, 24(11), 1456-1462. https://doi.org/10.1002/pon.3811

Vancouver

Faller H, Brähler E, Härter M, Keller M, Schulz H , Wegscheider K et al. Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis. PSYCHO-ONCOLOGY. 2015 Nov;24(11):1456-1462. https://doi.org/10.1002/pon.3811

Bibtex

@article{de9013c2e27e4aee8f534754f50a5eb4,

title = "Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis",

abstract = "OBJECTIVE: This study aimed to examine whether depressive symptoms and performance status are independent predictors of both the physical and psychological domains of health-related quality of life (HRQoL) in cancer patients.METHODS: A sample of 4020 cancer patients (mean age 58 years, 51% women) was evaluated. Depressive symptoms were measured with the patient health questionnaire and HRQoL with the European Organisation for Research and Treatment of Cancer quality of life questionnaire core 30. The impact of the illness on everyday activities was assessed with physician ratings of both the Karnofsky performance status and the Eastern Cooperative Oncology Group performance status. The simultaneous effects of depression and performance status on quality of life outcomes were estimated using structural equation modeling.RESULTS: Both depressive symptoms and performance status independently predicted the physical and psychological domains of HRQoL. However, the impact of depressive symptoms on the physical HRQoL was stronger than the impact of performance status on the psychological HRQoL.CONCLUSION: Our results suggest that comorbid depressive symptoms are independently associated with both physical and psychological HRQoL in cancer patients after controlling for the physician-rated performance status. Thus, comorbid depression should be taken into account when evaluating reduced HRQoL in cancer patients. To support a causal impact of depression on HRQoL, intervention studies are needed to show that improving depression enhances cancer patients' HRQoL. Copyright {\textcopyright} 2015 John Wiley & Sons, Ltd.",

author = "Hermann Faller and Elmar Br{\"a}hler and Martin H{\"a}rter and Monika Keller and Holger Schulz and Karl Wegscheider and Joachim Weis and Anna Boehncke and Matthias Richard and Susanne Sehner and Uwe Koch and Anja Mehnert",

note = "Copyright {\textcopyright} 2015 John Wiley & Sons, Ltd.",

year = "2015",

month = nov,

doi = "10.1002/pon.3811",

language = "English",

volume = "24",

pages = "1456--1462",

journal = "PSYCHO-ONCOLOGY",

issn = "1057-9249",

publisher = "John Wiley and Sons Ltd",

number = "11",

}

RIS

TY - JOUR

T1 - Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis

AU - Faller, Hermann

AU - Brähler, Elmar

AU - Härter, Martin

AU - Keller, Monika

AU - Schulz, Holger

AU - Wegscheider, Karl

AU - Weis, Joachim

AU - Boehncke, Anna

AU - Richard, Matthias

AU - Sehner, Susanne

AU - Koch, Uwe

AU - Mehnert, Anja

PY - 2015/11

Y1 - 2015/11

N2 - OBJECTIVE: This study aimed to examine whether depressive symptoms and performance status are independent predictors of both the physical and psychological domains of health-related quality of life (HRQoL) in cancer patients.METHODS: A sample of 4020 cancer patients (mean age 58 years, 51% women) was evaluated. Depressive symptoms were measured with the patient health questionnaire and HRQoL with the European Organisation for Research and Treatment of Cancer quality of life questionnaire core 30. The impact of the illness on everyday activities was assessed with physician ratings of both the Karnofsky performance status and the Eastern Cooperative Oncology Group performance status. The simultaneous effects of depression and performance status on quality of life outcomes were estimated using structural equation modeling.RESULTS: Both depressive symptoms and performance status independently predicted the physical and psychological domains of HRQoL. However, the impact of depressive symptoms on the physical HRQoL was stronger than the impact of performance status on the psychological HRQoL.CONCLUSION: Our results suggest that comorbid depressive symptoms are independently associated with both physical and psychological HRQoL in cancer patients after controlling for the physician-rated performance status. Thus, comorbid depression should be taken into account when evaluating reduced HRQoL in cancer patients. To support a causal impact of depression on HRQoL, intervention studies are needed to show that improving depression enhances cancer patients' HRQoL. Copyright © 2015 John Wiley & Sons, Ltd.

AB - OBJECTIVE: This study aimed to examine whether depressive symptoms and performance status are independent predictors of both the physical and psychological domains of health-related quality of life (HRQoL) in cancer patients.METHODS: A sample of 4020 cancer patients (mean age 58 years, 51% women) was evaluated. Depressive symptoms were measured with the patient health questionnaire and HRQoL with the European Organisation for Research and Treatment of Cancer quality of life questionnaire core 30. The impact of the illness on everyday activities was assessed with physician ratings of both the Karnofsky performance status and the Eastern Cooperative Oncology Group performance status. The simultaneous effects of depression and performance status on quality of life outcomes were estimated using structural equation modeling.RESULTS: Both depressive symptoms and performance status independently predicted the physical and psychological domains of HRQoL. However, the impact of depressive symptoms on the physical HRQoL was stronger than the impact of performance status on the psychological HRQoL.CONCLUSION: Our results suggest that comorbid depressive symptoms are independently associated with both physical and psychological HRQoL in cancer patients after controlling for the physician-rated performance status. Thus, comorbid depression should be taken into account when evaluating reduced HRQoL in cancer patients. To support a causal impact of depression on HRQoL, intervention studies are needed to show that improving depression enhances cancer patients' HRQoL. Copyright © 2015 John Wiley & Sons, Ltd.

U2 - 10.1002/pon.3811

DO - 10.1002/pon.3811

M3 - SCORING: Journal article

C2 - 25851732

VL - 24

SP - 1456

EP - 1462

JO - PSYCHO-ONCOLOGY

JF - PSYCHO-ONCOLOGY

SN - 1057-9249

IS - 11

ER -