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Pedophilic sex offenders are characterised by reduced GABA concentration in dorsal anterior cingulate cortex

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Pedophilic sex offenders are characterised by reduced GABA concentration in dorsal anterior cingulate cortex. / Ristow, Inka; Li, Meng; Colic, Lejla; Marr, Vanessa; Födisch, Carina; von Düring, Felicia; Schiltz, Kolja; Drumkova, Krasimira; Witzel, Joachim; Walter, Henrik; Beier, Klaus; Kruger, Tillmann H C; Ponseti, Jorge; Schiffer, Boris; Walter, Martin.

In: NEUROIMAGE-CLIN, Vol. 18, 2018, p. 335-341.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ristow, I, Li, M, Colic, L, Marr, V, Födisch, C, von Düring, F, Schiltz, K, Drumkova, K, Witzel, J, Walter, H, Beier, K, Kruger, THC, Ponseti, J, Schiffer, B & Walter, M 2018, 'Pedophilic sex offenders are characterised by reduced GABA concentration in dorsal anterior cingulate cortex', NEUROIMAGE-CLIN, vol. 18, pp. 335-341. https://doi.org/10.1016/j.nicl.2018.01.018

APA

Ristow, I., Li, M., Colic, L., Marr, V., Födisch, C., von Düring, F., Schiltz, K., Drumkova, K., Witzel, J., Walter, H., Beier, K., Kruger, T. H. C., Ponseti, J., Schiffer, B., & Walter, M. (2018). Pedophilic sex offenders are characterised by reduced GABA concentration in dorsal anterior cingulate cortex. NEUROIMAGE-CLIN, 18, 335-341. https://doi.org/10.1016/j.nicl.2018.01.018

Vancouver

Ristow I, Li M, Colic L, Marr V, Födisch C, von Düring F et al. Pedophilic sex offenders are characterised by reduced GABA concentration in dorsal anterior cingulate cortex. NEUROIMAGE-CLIN. 2018;18:335-341. https://doi.org/10.1016/j.nicl.2018.01.018

Bibtex

@article{42e00e9a8822401ba0ac53dc635a4374,
title = "Pedophilic sex offenders are characterised by reduced GABA concentration in dorsal anterior cingulate cortex",
abstract = "A pedophilic disorder is characterised by abnormal sexual urges towards prepubescent children. Child abusive behavior is frequently a result of lack of behavioral inhibition and current treatment options entail, next to suppressing unchangeable sexual orientation, measures to increase cognitive and attentional control. We tested, if in brain regions subserving attentional control of behavior and perception of salient stimuli, such inhibition deficit can be observed also on the level of inhibitory neurotransmitters. We measured GABA concentration in the dorsal anterior cingulate cortex (dACC) and in a control region, the pregenual anterior cingulate cortex (pgACC) in pedophilic sex offenders (N = 13) and matched controls (N = 13) using a 7 Tesla STEAM magnetic resonance spectroscopy (MRS). In dACC but not in the control region pedophilic sex offenders showed reduced GABA/Cr concentrations compared to healthy controls. The reduction was robust after controlling for potential influence of age and gray matter proportion within the MRS voxel (p < 0.04). Importantly, reduced GABA/Cr in patients was correlated with lower self-control measured with the Barratt Impulsiveness Scale (p = 0.028, r = -0.689). In a region related to cognitive control and salience mapping, pedophilic sex offenders showed reduction of the inhibitory neurotransmitter GABA which may be seen as a neuronal correlate of inhibition and behavioral control.",
keywords = "Adult, Brain Mapping, Correlation of Data, Creatine, Gyrus Cinguli, Humans, Inhibition (Psychology), Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Middle Aged, Pedophilia, Sex Offenses, Young Adult, gamma-Aminobutyric Acid, Journal Article, Research Support, Non-U.S. Gov't",
author = "Inka Ristow and Meng Li and Lejla Colic and Vanessa Marr and Carina F{\"o}disch and {von D{\"u}ring}, Felicia and Kolja Schiltz and Krasimira Drumkova and Joachim Witzel and Henrik Walter and Klaus Beier and Kruger, {Tillmann H C} and Jorge Ponseti and Boris Schiffer and Martin Walter",
year = "2018",
doi = "10.1016/j.nicl.2018.01.018",
language = "English",
volume = "18",
pages = "335--341",
journal = "NEUROIMAGE-CLIN",
issn = "2213-1582",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Pedophilic sex offenders are characterised by reduced GABA concentration in dorsal anterior cingulate cortex

AU - Ristow, Inka

AU - Li, Meng

AU - Colic, Lejla

AU - Marr, Vanessa

AU - Födisch, Carina

AU - von Düring, Felicia

AU - Schiltz, Kolja

AU - Drumkova, Krasimira

AU - Witzel, Joachim

AU - Walter, Henrik

AU - Beier, Klaus

AU - Kruger, Tillmann H C

AU - Ponseti, Jorge

AU - Schiffer, Boris

AU - Walter, Martin

PY - 2018

Y1 - 2018

N2 - A pedophilic disorder is characterised by abnormal sexual urges towards prepubescent children. Child abusive behavior is frequently a result of lack of behavioral inhibition and current treatment options entail, next to suppressing unchangeable sexual orientation, measures to increase cognitive and attentional control. We tested, if in brain regions subserving attentional control of behavior and perception of salient stimuli, such inhibition deficit can be observed also on the level of inhibitory neurotransmitters. We measured GABA concentration in the dorsal anterior cingulate cortex (dACC) and in a control region, the pregenual anterior cingulate cortex (pgACC) in pedophilic sex offenders (N = 13) and matched controls (N = 13) using a 7 Tesla STEAM magnetic resonance spectroscopy (MRS). In dACC but not in the control region pedophilic sex offenders showed reduced GABA/Cr concentrations compared to healthy controls. The reduction was robust after controlling for potential influence of age and gray matter proportion within the MRS voxel (p < 0.04). Importantly, reduced GABA/Cr in patients was correlated with lower self-control measured with the Barratt Impulsiveness Scale (p = 0.028, r = -0.689). In a region related to cognitive control and salience mapping, pedophilic sex offenders showed reduction of the inhibitory neurotransmitter GABA which may be seen as a neuronal correlate of inhibition and behavioral control.

AB - A pedophilic disorder is characterised by abnormal sexual urges towards prepubescent children. Child abusive behavior is frequently a result of lack of behavioral inhibition and current treatment options entail, next to suppressing unchangeable sexual orientation, measures to increase cognitive and attentional control. We tested, if in brain regions subserving attentional control of behavior and perception of salient stimuli, such inhibition deficit can be observed also on the level of inhibitory neurotransmitters. We measured GABA concentration in the dorsal anterior cingulate cortex (dACC) and in a control region, the pregenual anterior cingulate cortex (pgACC) in pedophilic sex offenders (N = 13) and matched controls (N = 13) using a 7 Tesla STEAM magnetic resonance spectroscopy (MRS). In dACC but not in the control region pedophilic sex offenders showed reduced GABA/Cr concentrations compared to healthy controls. The reduction was robust after controlling for potential influence of age and gray matter proportion within the MRS voxel (p < 0.04). Importantly, reduced GABA/Cr in patients was correlated with lower self-control measured with the Barratt Impulsiveness Scale (p = 0.028, r = -0.689). In a region related to cognitive control and salience mapping, pedophilic sex offenders showed reduction of the inhibitory neurotransmitter GABA which may be seen as a neuronal correlate of inhibition and behavioral control.

KW - Adult

KW - Brain Mapping

KW - Correlation of Data

KW - Creatine

KW - Gyrus Cinguli

KW - Humans

KW - Inhibition (Psychology)

KW - Magnetic Resonance Imaging

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Middle Aged

KW - Pedophilia

KW - Sex Offenses

KW - Young Adult

KW - gamma-Aminobutyric Acid

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.nicl.2018.01.018

DO - 10.1016/j.nicl.2018.01.018

M3 - SCORING: Journal article

C2 - 29876253

VL - 18

SP - 335

EP - 341

JO - NEUROIMAGE-CLIN

JF - NEUROIMAGE-CLIN

SN - 2213-1582

ER -