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PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog

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PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog. / Wideman, Jeremy G; Balacco, Dario L; Fieblinger, Tim; Richards, Thomas A.

In: F1000 Research, Vol. 7, 2018, p. 1088.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wideman, JG, Balacco, DL, Fieblinger, T & Richards, TA 2018, 'PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog', F1000 Research, vol. 7, pp. 1088. https://doi.org/10.12688/f1000research.15523.1

APA

Wideman, J. G., Balacco, D. L., Fieblinger, T., & Richards, T. A. (2018). PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog. F1000 Research, 7, 1088. https://doi.org/10.12688/f1000research.15523.1

Vancouver

Wideman JG, Balacco DL, Fieblinger T, Richards TA. PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog. F1000 Research. 2018;7:1088. https://doi.org/10.12688/f1000research.15523.1

Bibtex

@article{0593348238a340779b3cd784c093d712,
title = "PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog",
abstract = "Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a {"}functional ortholog{"} of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data with respect to the evolution of ER-mitochondria tethering. Our phylogenetic analyses show that PDZD8 co-occurs with ERMES components in lineages closely related to animals solidifying its identity as a paralog of Mmm1. Additionally, we identify two related paralogs, one specific to flagellated fungi, and one present only in unicellular relatives of animals. These results point to a complex evolutionary history of ER-mitochondria tethering involving multiple gene gains and losses in the lineage leading to animals and fungi.",
keywords = "Animals, Humans, Mitochondrial Proteins/genetics, Phylogeny, Saccharomyces cerevisiae/genetics, Saccharomyces cerevisiae Proteins/genetics",
author = "Wideman, {Jeremy G} and Balacco, {Dario L} and Tim Fieblinger and Richards, {Thomas A}",
year = "2018",
doi = "10.12688/f1000research.15523.1",
language = "English",
volume = "7",
pages = "1088",

}

RIS

TY - JOUR

T1 - PDZD8 is not the 'functional ortholog' of Mmm1, it is a paralog

AU - Wideman, Jeremy G

AU - Balacco, Dario L

AU - Fieblinger, Tim

AU - Richards, Thomas A

PY - 2018

Y1 - 2018

N2 - Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a "functional ortholog" of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data with respect to the evolution of ER-mitochondria tethering. Our phylogenetic analyses show that PDZD8 co-occurs with ERMES components in lineages closely related to animals solidifying its identity as a paralog of Mmm1. Additionally, we identify two related paralogs, one specific to flagellated fungi, and one present only in unicellular relatives of animals. These results point to a complex evolutionary history of ER-mitochondria tethering involving multiple gene gains and losses in the lineage leading to animals and fungi.

AB - Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a "functional ortholog" of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data with respect to the evolution of ER-mitochondria tethering. Our phylogenetic analyses show that PDZD8 co-occurs with ERMES components in lineages closely related to animals solidifying its identity as a paralog of Mmm1. Additionally, we identify two related paralogs, one specific to flagellated fungi, and one present only in unicellular relatives of animals. These results point to a complex evolutionary history of ER-mitochondria tethering involving multiple gene gains and losses in the lineage leading to animals and fungi.

KW - Animals

KW - Humans

KW - Mitochondrial Proteins/genetics

KW - Phylogeny

KW - Saccharomyces cerevisiae/genetics

KW - Saccharomyces cerevisiae Proteins/genetics

U2 - 10.12688/f1000research.15523.1

DO - 10.12688/f1000research.15523.1

M3 - SCORING: Journal article

C2 - 30109028

VL - 7

SP - 1088

ER -