Research ExplorerPublicationsPatterns of distant metastases in vulvar cancer

Patterns of distant metastases in vulvar cancer

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Patterns of distant metastases in vulvar cancer. / Prieske, Katharina; Haeringer, Nicole; Grimm, Donata; Trillsch, Fabian; Eulenburg, Christine; Burandt, Eike; Schmalfeldt, Barbara; Mahner, Sven; Mueller, Volkmar; Woelber, Linn.

In: GYNECOL ONCOL, Vol. 142, No. 3, 09.2016, p. 427-34.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Prieske, K, Haeringer, N, Grimm, D, Trillsch, F, Eulenburg, C, Burandt, E, Schmalfeldt, B, Mahner, S, Mueller, V & Woelber, L 2016, 'Patterns of distant metastases in vulvar cancer', GYNECOL ONCOL, vol. 142, no. 3, pp. 427-34. https://doi.org/10.1016/j.ygyno.2016.07.009

APA

Prieske, K., Haeringer, N., Grimm, D., Trillsch, F., Eulenburg, C., Burandt, E., Schmalfeldt, B., Mahner, S., Mueller, V., & Woelber, L. (2016). Patterns of distant metastases in vulvar cancer. GYNECOL ONCOL, 142(3), 427-34. https://doi.org/10.1016/j.ygyno.2016.07.009

Vancouver

Prieske K, Haeringer N, Grimm D, Trillsch F, Eulenburg C, Burandt E et al. Patterns of distant metastases in vulvar cancer. GYNECOL ONCOL. 2016 Sep;142(3):427-34. https://doi.org/10.1016/j.ygyno.2016.07.009

Bibtex

@article{d799adbbd54b441289339b1493849888,
title = "Patterns of distant metastases in vulvar cancer",
abstract = "OBJECTIVE: Metastatic vulvar cancer is a rare disease. Information on metastatic patterns and corresponding prognosis or therapeutic approaches is scarce. We therefore analyzed pattern and course of metastatic disease in a large single center cohort.METHODS: All patients with primary squamous-cell cancer of the vulvar [n=391, median age: 60years (range 20-94)] treated at the Gynecological Cancer Center Hamburg-Eppendorf 1996-2013 were retrospectively evaluated for occurrence of distant metastasis. Furthermore, a systematic Medline database search was performed using the terms: 'vulvar cancer' AND 'metastasis', 'chemotherapy', 'patterns of recurrence', or 'prognosis'.RESULTS: Out of 391 patients with primary squamous cell vulvar cancer, 20 patients (5.1%) eventually presented with distant metastases. In these 20 patients, median time to first diagnosis of metastasis after primary diagnosis was 13.4months (range 4-104). Often patients experienced one or more local recurrences before distant spread (12/20, 60.0%). Documented metastatic sites were lung (n=9), liver (n=7), bone (n=5), skin (n=4) and lymph-nodes (axillary/thoracic/paraaortic, n=3). The majority of patients presented with unilocal metastases (13/20, 65.0%). In univariate analysis tumor diameter, invasion depth, nodal status and number of metastatic lymph-nodes were identified predictive for occurrence of distant metastases. 2-year-overall-survival-rate after metastases of all metastatic patients was 11.3%; median survival from first diagnosis of metastases was 5.6months.CONCLUSION: The occurrence of distant metastasis from vulvar cancer is a rare event with very limited prognosis. Further efforts, especially translational research will be crucial to identify prognostic markers as well as therapeutic targets to improve survival in these patients.",
keywords = "Journal Article",
author = "Katharina Prieske and Nicole Haeringer and Donata Grimm and Fabian Trillsch and Christine Eulenburg and Eike Burandt and Barbara Schmalfeldt and Sven Mahner and Volkmar Mueller and Linn Woelber",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = sep,
doi = "10.1016/j.ygyno.2016.07.009",
language = "English",
volume = "142",
pages = "427--34",
journal = "GYNECOL ONCOL",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Patterns of distant metastases in vulvar cancer

AU - Prieske, Katharina

AU - Haeringer, Nicole

AU - Grimm, Donata

AU - Trillsch, Fabian

AU - Eulenburg, Christine

AU - Burandt, Eike

AU - Schmalfeldt, Barbara

AU - Mahner, Sven

AU - Mueller, Volkmar

AU - Woelber, Linn

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/9

Y1 - 2016/9

N2 - OBJECTIVE: Metastatic vulvar cancer is a rare disease. Information on metastatic patterns and corresponding prognosis or therapeutic approaches is scarce. We therefore analyzed pattern and course of metastatic disease in a large single center cohort.METHODS: All patients with primary squamous-cell cancer of the vulvar [n=391, median age: 60years (range 20-94)] treated at the Gynecological Cancer Center Hamburg-Eppendorf 1996-2013 were retrospectively evaluated for occurrence of distant metastasis. Furthermore, a systematic Medline database search was performed using the terms: 'vulvar cancer' AND 'metastasis', 'chemotherapy', 'patterns of recurrence', or 'prognosis'.RESULTS: Out of 391 patients with primary squamous cell vulvar cancer, 20 patients (5.1%) eventually presented with distant metastases. In these 20 patients, median time to first diagnosis of metastasis after primary diagnosis was 13.4months (range 4-104). Often patients experienced one or more local recurrences before distant spread (12/20, 60.0%). Documented metastatic sites were lung (n=9), liver (n=7), bone (n=5), skin (n=4) and lymph-nodes (axillary/thoracic/paraaortic, n=3). The majority of patients presented with unilocal metastases (13/20, 65.0%). In univariate analysis tumor diameter, invasion depth, nodal status and number of metastatic lymph-nodes were identified predictive for occurrence of distant metastases. 2-year-overall-survival-rate after metastases of all metastatic patients was 11.3%; median survival from first diagnosis of metastases was 5.6months.CONCLUSION: The occurrence of distant metastasis from vulvar cancer is a rare event with very limited prognosis. Further efforts, especially translational research will be crucial to identify prognostic markers as well as therapeutic targets to improve survival in these patients.

AB - OBJECTIVE: Metastatic vulvar cancer is a rare disease. Information on metastatic patterns and corresponding prognosis or therapeutic approaches is scarce. We therefore analyzed pattern and course of metastatic disease in a large single center cohort.METHODS: All patients with primary squamous-cell cancer of the vulvar [n=391, median age: 60years (range 20-94)] treated at the Gynecological Cancer Center Hamburg-Eppendorf 1996-2013 were retrospectively evaluated for occurrence of distant metastasis. Furthermore, a systematic Medline database search was performed using the terms: 'vulvar cancer' AND 'metastasis', 'chemotherapy', 'patterns of recurrence', or 'prognosis'.RESULTS: Out of 391 patients with primary squamous cell vulvar cancer, 20 patients (5.1%) eventually presented with distant metastases. In these 20 patients, median time to first diagnosis of metastasis after primary diagnosis was 13.4months (range 4-104). Often patients experienced one or more local recurrences before distant spread (12/20, 60.0%). Documented metastatic sites were lung (n=9), liver (n=7), bone (n=5), skin (n=4) and lymph-nodes (axillary/thoracic/paraaortic, n=3). The majority of patients presented with unilocal metastases (13/20, 65.0%). In univariate analysis tumor diameter, invasion depth, nodal status and number of metastatic lymph-nodes were identified predictive for occurrence of distant metastases. 2-year-overall-survival-rate after metastases of all metastatic patients was 11.3%; median survival from first diagnosis of metastases was 5.6months.CONCLUSION: The occurrence of distant metastasis from vulvar cancer is a rare event with very limited prognosis. Further efforts, especially translational research will be crucial to identify prognostic markers as well as therapeutic targets to improve survival in these patients.

KW - Journal Article

U2 - 10.1016/j.ygyno.2016.07.009

DO - 10.1016/j.ygyno.2016.07.009

M3 - SCORING: Journal article

C2 - 27401841

VL - 142

SP - 427

EP - 434

JO - GYNECOL ONCOL

JF - GYNECOL ONCOL

SN - 0090-8258

IS - 3

ER -