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Patterns of chromosomal aberrations in urinary bladder tumours and adjacent urothelium.

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Patterns of chromosomal aberrations in urinary bladder tumours and adjacent urothelium. / Steidl, Christian; Simon, Ronald; Bürger, Horst; Brinkschmidt, Christian; Hertle, Lothar; Böcker, Werner; Terpe, Hans-Joachim.

In: J PATHOL, Vol. 198, No. 1, 1, 2002, p. 115-120.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Steidl, C, Simon, R, Bürger, H, Brinkschmidt, C, Hertle, L, Böcker, W & Terpe, H-J 2002, 'Patterns of chromosomal aberrations in urinary bladder tumours and adjacent urothelium.', J PATHOL, vol. 198, no. 1, 1, pp. 115-120. <http://www.ncbi.nlm.nih.gov/pubmed/12210071?dopt=Citation>

APA

Steidl, C., Simon, R., Bürger, H., Brinkschmidt, C., Hertle, L., Böcker, W., & Terpe, H-J. (2002). Patterns of chromosomal aberrations in urinary bladder tumours and adjacent urothelium. J PATHOL, 198(1), 115-120. [1]. http://www.ncbi.nlm.nih.gov/pubmed/12210071?dopt=Citation

Vancouver

Steidl C, Simon R, Bürger H, Brinkschmidt C, Hertle L, Böcker W et al. Patterns of chromosomal aberrations in urinary bladder tumours and adjacent urothelium. J PATHOL. 2002;198(1):115-120. 1.

Bibtex

@article{29b936ce2514442ba0a949109c2ef9ba,
title = "Patterns of chromosomal aberrations in urinary bladder tumours and adjacent urothelium.",
abstract = "Bladder cancer is often characterized by recurrent and multifocal growth, and tumours are frequently accompanied by precancerous alterations of the surrounding urothelium. These findings have led to the hypothesis that cells from areas of genetically aberrant but morphologically non-cancerous or even unremarkable mucosa may be the source of bladder carcinomas. Fluorescence in situ hybridization (FISH) was performed using ten probes targeting five different chromosomes that are known to be frequently altered in bladder cancer (centromere 1, 8, 9, 11, 17 and 1p36, 8p23, 9p21, 11q13, 17p13) on paraffin-embedded tissue sections of 11 superficial bladder cancers. Copy number changes of the tumours were compared to those in the urothelium adjacent to the tumour. Eleven of 11 (100%) tumours and eight of 11 (73%) samples of adjacent urothelium showed copy number changes of at least one chromosome. The occurrence of similar patterns of chromosomal aberrations in the tumours and their associated urothelium supports the hypothesis of a clonal relationship. It is concluded that FISH analysis targeting five different chromosomes is more sensitive than conventional histology for distinguishing between neoplastic and normal cells of the urothelium.",
author = "Christian Steidl and Ronald Simon and Horst B{\"u}rger and Christian Brinkschmidt and Lothar Hertle and Werner B{\"o}cker and Hans-Joachim Terpe",
year = "2002",
language = "Deutsch",
volume = "198",
pages = "115--120",
journal = "J PATHOL",
issn = "0022-3417",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Patterns of chromosomal aberrations in urinary bladder tumours and adjacent urothelium.

AU - Steidl, Christian

AU - Simon, Ronald

AU - Bürger, Horst

AU - Brinkschmidt, Christian

AU - Hertle, Lothar

AU - Böcker, Werner

AU - Terpe, Hans-Joachim

PY - 2002

Y1 - 2002

N2 - Bladder cancer is often characterized by recurrent and multifocal growth, and tumours are frequently accompanied by precancerous alterations of the surrounding urothelium. These findings have led to the hypothesis that cells from areas of genetically aberrant but morphologically non-cancerous or even unremarkable mucosa may be the source of bladder carcinomas. Fluorescence in situ hybridization (FISH) was performed using ten probes targeting five different chromosomes that are known to be frequently altered in bladder cancer (centromere 1, 8, 9, 11, 17 and 1p36, 8p23, 9p21, 11q13, 17p13) on paraffin-embedded tissue sections of 11 superficial bladder cancers. Copy number changes of the tumours were compared to those in the urothelium adjacent to the tumour. Eleven of 11 (100%) tumours and eight of 11 (73%) samples of adjacent urothelium showed copy number changes of at least one chromosome. The occurrence of similar patterns of chromosomal aberrations in the tumours and their associated urothelium supports the hypothesis of a clonal relationship. It is concluded that FISH analysis targeting five different chromosomes is more sensitive than conventional histology for distinguishing between neoplastic and normal cells of the urothelium.

AB - Bladder cancer is often characterized by recurrent and multifocal growth, and tumours are frequently accompanied by precancerous alterations of the surrounding urothelium. These findings have led to the hypothesis that cells from areas of genetically aberrant but morphologically non-cancerous or even unremarkable mucosa may be the source of bladder carcinomas. Fluorescence in situ hybridization (FISH) was performed using ten probes targeting five different chromosomes that are known to be frequently altered in bladder cancer (centromere 1, 8, 9, 11, 17 and 1p36, 8p23, 9p21, 11q13, 17p13) on paraffin-embedded tissue sections of 11 superficial bladder cancers. Copy number changes of the tumours were compared to those in the urothelium adjacent to the tumour. Eleven of 11 (100%) tumours and eight of 11 (73%) samples of adjacent urothelium showed copy number changes of at least one chromosome. The occurrence of similar patterns of chromosomal aberrations in the tumours and their associated urothelium supports the hypothesis of a clonal relationship. It is concluded that FISH analysis targeting five different chromosomes is more sensitive than conventional histology for distinguishing between neoplastic and normal cells of the urothelium.

M3 - SCORING: Zeitschriftenaufsatz

VL - 198

SP - 115

EP - 120

JO - J PATHOL

JF - J PATHOL

SN - 0022-3417

IS - 1

M1 - 1

ER -