Pattern of recurrence following local chemotherapy with biodegradable carmustine (BCNU) implants in patients with glioblastoma.

  • Alf Giese
  • Thomas Kucinski
  • Ulrich Knopp
  • Roland Goldbrunner
  • Wolfgang Hamel
  • H M Mehdorn
  • Jörg C Tonn
  • Dana Hilt
  • Manfred Westphal

Related Research units

Abstract

Recently a randomized placebo-controlled phase III trial of biodegradable polymers containing carmustine has demonstrated a significant survival benefit for patients treated with local chemotherapy. A local chemotherapy applied directly to the resection cavity may act directly on residual tumor cells in adjacent brain possibly leading to a local control of the tumor and increased survival.

Bibliographical data

Original languageGerman
Article number3
ISSN0167-594X
Publication statusPublished - 2004
pubmed 15015668