Research ExplorerPublicationsPatient Characteristics, Treatment and Outcome in Non-Ischem...

Patient Characteristics, Treatment and Outcome in Non-Ischemic vs. Ischemic Cardiogenic Shock

Standard

Patient Characteristics, Treatment and Outcome in Non-Ischemic vs. Ischemic Cardiogenic Shock. / Schrage, Benedikt; Weimann, Jessica; Dabboura, Salim; Yan, Isabell; Hilal, Rafel; Becher, Peter Moritz; Seiffert, Moritz; Bernhardt, Alexander M; Kluge, Stefan; Reichenspurner, Hermann; Blankenberg, Stefan; Westermann, Dirk.

In: J CLIN MED, Vol. 9, No. 4, 28.03.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schrage, B, Weimann, J, Dabboura, S, Yan, I, Hilal, R, Becher, PM, Seiffert, M, Bernhardt, AM, Kluge, S, Reichenspurner, H, Blankenberg, S & Westermann, D 2020, 'Patient Characteristics, Treatment and Outcome in Non-Ischemic vs. Ischemic Cardiogenic Shock', J CLIN MED, vol. 9, no. 4. https://doi.org/10.3390/jcm9040931

APA

Schrage, B., Weimann, J., Dabboura, S., Yan, I., Hilal, R., Becher, P. M., Seiffert, M., Bernhardt, A. M., Kluge, S., Reichenspurner, H., Blankenberg, S., & Westermann, D. (2020). Patient Characteristics, Treatment and Outcome in Non-Ischemic vs. Ischemic Cardiogenic Shock. J CLIN MED, 9(4). https://doi.org/10.3390/jcm9040931

Vancouver

Schrage B, Weimann J, Dabboura S, Yan I, Hilal R, Becher PM et al. Patient Characteristics, Treatment and Outcome in Non-Ischemic vs. Ischemic Cardiogenic Shock. J CLIN MED. 2020 Mar 28;9(4). https://doi.org/10.3390/jcm9040931

Bibtex

@article{1f72fee8821241a987cba2c926e08d4c,
title = "Patient Characteristics, Treatment and Outcome in Non-Ischemic vs. Ischemic Cardiogenic Shock",
abstract = ": Aim: Evidence on non-ischemic cardiogenic shock (CS) is scarce. The aim of this study was to investigate differences in patient characteristics, use of treatments and outcomes in patients with non-ischemic vs. ischemic CS.METHODS: Patients with CS admitted between October 2009 and October 2017 were identified and stratified as non-ischemic/ischemic CS based on the absence/presence of acute myocardial infarction. Logistic/Cox regression models were fitted to investigate the association between non-ischemic CS and patient characteristics, use of treatments and 30-day in-hospital mortality.RESULTS: A total of 978 patients were enrolled in this study; median age was 70 (interquartile range 58, 79) years and 70% were male. Of these, 505 patients (52%) had non-ischemic CS. Patients with non-ischemic CS were more likely to be younger and female; were less likely to be active smokers, to have diabetes or decreased renal function, but more likely to have a history of myocardial infarction; and they were more likely to present with unfavorable hemodynamics and with mechanical ventilation. Regarding treatments, patients with non-ischemic CS were more likely to be treated with catecholamines, but less likely to be treated with extracorporeal membrane oxygenation or percutaneous left-ventricular assist devices. After adjustment for multiple relevant confounders, non-ischemic CS was associated with a significant increase in the risk of 30-day in-hospital mortality (hazard ratio 1.14, 95% confidence interval 1.04-1.24, p < 0.01).CONCLUSION: In this large study, non-ischemic CS accounted for more than 50% of all CS cases. Non-ischemic CS was not only associated with relevant differences in patient characteristics and use of treatments, but also with a worse prognosis. These findings highlight the need for effective treatment strategies for patients with non-ischemic CS.",
author = "Benedikt Schrage and Jessica Weimann and Salim Dabboura and Isabell Yan and Rafel Hilal and Becher, {Peter Moritz} and Moritz Seiffert and Bernhardt, {Alexander M} and Stefan Kluge and Hermann Reichenspurner and Stefan Blankenberg and Dirk Westermann",
year = "2020",
month = mar,
day = "28",
doi = "10.3390/jcm9040931",
language = "English",
volume = "9",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Patient Characteristics, Treatment and Outcome in Non-Ischemic vs. Ischemic Cardiogenic Shock

AU - Schrage, Benedikt

AU - Weimann, Jessica

AU - Dabboura, Salim

AU - Yan, Isabell

AU - Hilal, Rafel

AU - Becher, Peter Moritz

AU - Seiffert, Moritz

AU - Bernhardt, Alexander M

AU - Kluge, Stefan

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Westermann, Dirk

PY - 2020/3/28

Y1 - 2020/3/28

N2 - : Aim: Evidence on non-ischemic cardiogenic shock (CS) is scarce. The aim of this study was to investigate differences in patient characteristics, use of treatments and outcomes in patients with non-ischemic vs. ischemic CS.METHODS: Patients with CS admitted between October 2009 and October 2017 were identified and stratified as non-ischemic/ischemic CS based on the absence/presence of acute myocardial infarction. Logistic/Cox regression models were fitted to investigate the association between non-ischemic CS and patient characteristics, use of treatments and 30-day in-hospital mortality.RESULTS: A total of 978 patients were enrolled in this study; median age was 70 (interquartile range 58, 79) years and 70% were male. Of these, 505 patients (52%) had non-ischemic CS. Patients with non-ischemic CS were more likely to be younger and female; were less likely to be active smokers, to have diabetes or decreased renal function, but more likely to have a history of myocardial infarction; and they were more likely to present with unfavorable hemodynamics and with mechanical ventilation. Regarding treatments, patients with non-ischemic CS were more likely to be treated with catecholamines, but less likely to be treated with extracorporeal membrane oxygenation or percutaneous left-ventricular assist devices. After adjustment for multiple relevant confounders, non-ischemic CS was associated with a significant increase in the risk of 30-day in-hospital mortality (hazard ratio 1.14, 95% confidence interval 1.04-1.24, p < 0.01).CONCLUSION: In this large study, non-ischemic CS accounted for more than 50% of all CS cases. Non-ischemic CS was not only associated with relevant differences in patient characteristics and use of treatments, but also with a worse prognosis. These findings highlight the need for effective treatment strategies for patients with non-ischemic CS.

AB - : Aim: Evidence on non-ischemic cardiogenic shock (CS) is scarce. The aim of this study was to investigate differences in patient characteristics, use of treatments and outcomes in patients with non-ischemic vs. ischemic CS.METHODS: Patients with CS admitted between October 2009 and October 2017 were identified and stratified as non-ischemic/ischemic CS based on the absence/presence of acute myocardial infarction. Logistic/Cox regression models were fitted to investigate the association between non-ischemic CS and patient characteristics, use of treatments and 30-day in-hospital mortality.RESULTS: A total of 978 patients were enrolled in this study; median age was 70 (interquartile range 58, 79) years and 70% were male. Of these, 505 patients (52%) had non-ischemic CS. Patients with non-ischemic CS were more likely to be younger and female; were less likely to be active smokers, to have diabetes or decreased renal function, but more likely to have a history of myocardial infarction; and they were more likely to present with unfavorable hemodynamics and with mechanical ventilation. Regarding treatments, patients with non-ischemic CS were more likely to be treated with catecholamines, but less likely to be treated with extracorporeal membrane oxygenation or percutaneous left-ventricular assist devices. After adjustment for multiple relevant confounders, non-ischemic CS was associated with a significant increase in the risk of 30-day in-hospital mortality (hazard ratio 1.14, 95% confidence interval 1.04-1.24, p < 0.01).CONCLUSION: In this large study, non-ischemic CS accounted for more than 50% of all CS cases. Non-ischemic CS was not only associated with relevant differences in patient characteristics and use of treatments, but also with a worse prognosis. These findings highlight the need for effective treatment strategies for patients with non-ischemic CS.

U2 - 10.3390/jcm9040931

DO - 10.3390/jcm9040931

M3 - SCORING: Journal article

C2 - 32231121

VL - 9

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 4

ER -