Research ExplorerPublicationsPathophysiologie und Pathomorphologie der Osteoporose

Pathophysiologie und Pathomorphologie der Osteoporose

Standard

Pathophysiologie und Pathomorphologie der Osteoporose. / Priemel, M; Münch, C; Beil, F T; Ritzel, H; Amling, M.

In: RADIOLOGE, Vol. 46, No. 10, 01.10.2006, p. 831-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Priemel, M, Münch, C, Beil, FT, Ritzel, H & Amling, M 2006, 'Pathophysiologie und Pathomorphologie der Osteoporose', RADIOLOGE, vol. 46, no. 10, pp. 831-8. https://doi.org/10.1007/s00117-006-1413-4

APA

Priemel, M., Münch, C., Beil, F. T., Ritzel, H., & Amling, M. (2006). Pathophysiologie und Pathomorphologie der Osteoporose. RADIOLOGE, 46(10), 831-8. https://doi.org/10.1007/s00117-006-1413-4

Vancouver

Priemel M, Münch C, Beil FT, Ritzel H, Amling M. Pathophysiologie und Pathomorphologie der Osteoporose. RADIOLOGE. 2006 Oct 1;46(10):831-8. https://doi.org/10.1007/s00117-006-1413-4

Bibtex

@article{487be63d324c428ba07a019f180f6fdd,
title = "Pathophysiologie und Pathomorphologie der Osteoporose",
abstract = "Osteoporosis is a disease that leads to fragility fractures due to loss of bone mass and bone microstructure. This review presents an update on the fundamental pathophysiologic and pathomorphologic mechanisms of bone loss situations. Pathomorphologic characteristics such as perforations and microcallus formations are explained. The physiologic relevance of the remodeling process as well as its control by local-paracrine, systemic-endocrine and central-neural signaling pathways is discussed. Furthermore the role of hormones such as estrogen, FSH and leptin, of transcription-factors such as Runx2 and osterix and as well as that of the wnt signaling pathway for bone cell differentiation and function is presented. On the basis of current knowledge osteoporosis can be diagnosed, treated and fractures can be prevented. However, it is likely that new and even more effective diagnostic and therapeutic strategies will emerge as our understanding of the remodeling process that controls osteoblast and osteoclast function increases.",
keywords = "Bone Resorption, Bone and Bones, Calcification, Physiologic, Fractures, Spontaneous, Growth Hormone, Humans, Models, Biological, Osteoporosis",
author = "M Priemel and C M{\"u}nch and Beil, {F T} and H Ritzel and M Amling",
year = "2006",
month = oct,
day = "1",
doi = "10.1007/s00117-006-1413-4",
language = "Deutsch",
volume = "46",
pages = "831--8",
journal = "RADIOLOGE",
issn = "0033-832X",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Pathophysiologie und Pathomorphologie der Osteoporose

AU - Priemel, M

AU - Münch, C

AU - Beil, F T

AU - Ritzel, H

AU - Amling, M

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Osteoporosis is a disease that leads to fragility fractures due to loss of bone mass and bone microstructure. This review presents an update on the fundamental pathophysiologic and pathomorphologic mechanisms of bone loss situations. Pathomorphologic characteristics such as perforations and microcallus formations are explained. The physiologic relevance of the remodeling process as well as its control by local-paracrine, systemic-endocrine and central-neural signaling pathways is discussed. Furthermore the role of hormones such as estrogen, FSH and leptin, of transcription-factors such as Runx2 and osterix and as well as that of the wnt signaling pathway for bone cell differentiation and function is presented. On the basis of current knowledge osteoporosis can be diagnosed, treated and fractures can be prevented. However, it is likely that new and even more effective diagnostic and therapeutic strategies will emerge as our understanding of the remodeling process that controls osteoblast and osteoclast function increases.

AB - Osteoporosis is a disease that leads to fragility fractures due to loss of bone mass and bone microstructure. This review presents an update on the fundamental pathophysiologic and pathomorphologic mechanisms of bone loss situations. Pathomorphologic characteristics such as perforations and microcallus formations are explained. The physiologic relevance of the remodeling process as well as its control by local-paracrine, systemic-endocrine and central-neural signaling pathways is discussed. Furthermore the role of hormones such as estrogen, FSH and leptin, of transcription-factors such as Runx2 and osterix and as well as that of the wnt signaling pathway for bone cell differentiation and function is presented. On the basis of current knowledge osteoporosis can be diagnosed, treated and fractures can be prevented. However, it is likely that new and even more effective diagnostic and therapeutic strategies will emerge as our understanding of the remodeling process that controls osteoblast and osteoclast function increases.

KW - Bone Resorption

KW - Bone and Bones

KW - Calcification, Physiologic

KW - Fractures, Spontaneous

KW - Growth Hormone

KW - Humans

KW - Models, Biological

KW - Osteoporosis

U2 - 10.1007/s00117-006-1413-4

DO - 10.1007/s00117-006-1413-4

M3 - SCORING: Zeitschriftenaufsatz

C2 - 16964480

VL - 46

SP - 831

EP - 838

JO - RADIOLOGE

JF - RADIOLOGE

SN - 0033-832X

IS - 10

ER -