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Pathological gambling is linked to reduced activation of the mesolimbic reward system

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Pathological gambling is linked to reduced activation of the mesolimbic reward system. / Reuter, Jan; Raedler, Thomas; Rose, Michael; Hand, Iver; Gläscher, Jan; Büchel, Christian.

In: NAT NEUROSCI, Vol. 8, No. 2, 01.02.2005, p. 147-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Reuter, J, Raedler, T, Rose, M, Hand, I, Gläscher, J & Büchel, C 2005, 'Pathological gambling is linked to reduced activation of the mesolimbic reward system', NAT NEUROSCI, vol. 8, no. 2, pp. 147-8. https://doi.org/10.1038/nn1378

APA

Reuter, J., Raedler, T., Rose, M., Hand, I., Gläscher, J., & Büchel, C. (2005). Pathological gambling is linked to reduced activation of the mesolimbic reward system. NAT NEUROSCI, 8(2), 147-8. https://doi.org/10.1038/nn1378

Vancouver

Reuter J, Raedler T, Rose M, Hand I, Gläscher J, Büchel C. Pathological gambling is linked to reduced activation of the mesolimbic reward system. NAT NEUROSCI. 2005 Feb 1;8(2):147-8. https://doi.org/10.1038/nn1378

Bibtex

@article{55742795be06468abea1c0eadcaa9e7a,
title = "Pathological gambling is linked to reduced activation of the mesolimbic reward system",
abstract = "By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.",
keywords = "Adult, Behavior, Addictive, Brain Mapping, Case-Control Studies, Functional Laterality, Gambling, Humans, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Prefrontal Cortex, Psychiatric Status Rating Scales, Regression Analysis, Reward, Risk-Taking",
author = "Jan Reuter and Thomas Raedler and Michael Rose and Iver Hand and Jan Gl{\"a}scher and Christian B{\"u}chel",
year = "2005",
month = feb,
day = "1",
doi = "10.1038/nn1378",
language = "English",
volume = "8",
pages = "147--8",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Pathological gambling is linked to reduced activation of the mesolimbic reward system

AU - Reuter, Jan

AU - Raedler, Thomas

AU - Rose, Michael

AU - Hand, Iver

AU - Gläscher, Jan

AU - Büchel, Christian

PY - 2005/2/1

Y1 - 2005/2/1

N2 - By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.

AB - By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.

KW - Adult

KW - Behavior, Addictive

KW - Brain Mapping

KW - Case-Control Studies

KW - Functional Laterality

KW - Gambling

KW - Humans

KW - Limbic System

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Neuropsychological Tests

KW - Oxygen

KW - Prefrontal Cortex

KW - Psychiatric Status Rating Scales

KW - Regression Analysis

KW - Reward

KW - Risk-Taking

U2 - 10.1038/nn1378

DO - 10.1038/nn1378

M3 - SCORING: Journal article

C2 - 15643429

VL - 8

SP - 147

EP - 148

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 2

ER -