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Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy: incidence and correlation with course of disease

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Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy: incidence and correlation with course of disease. / Vogel, Monika N; Weisel, Katja; Maksimovic, Olga; Peters, Sebastian; Brodoefel, Harald; Claussen, Claus D; Horger, Marius S.

In: AM J ROENTGENOL, Vol. 193, No. 3, 09.2009, p. 656-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vogel, MN, Weisel, K, Maksimovic, O, Peters, S, Brodoefel, H, Claussen, CD & Horger, MS 2009, 'Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy: incidence and correlation with course of disease', AM J ROENTGENOL, vol. 193, no. 3, pp. 656-61. https://doi.org/10.2214/AJR.08.2002

APA

Vogel, M. N., Weisel, K., Maksimovic, O., Peters, S., Brodoefel, H., Claussen, C. D., & Horger, M. S. (2009). Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy: incidence and correlation with course of disease. AM J ROENTGENOL, 193(3), 656-61. https://doi.org/10.2214/AJR.08.2002

Vancouver

Vogel MN, Weisel K, Maksimovic O, Peters S, Brodoefel H, Claussen CD et al. Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy: incidence and correlation with course of disease. AM J ROENTGENOL. 2009 Sep;193(3):656-61. https://doi.org/10.2214/AJR.08.2002

Bibtex

@article{33527a724add43e0a5a8b99d091c820a,
title = "Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy: incidence and correlation with course of disease",
abstract = "OBJECTIVE: The purposes of this study were single-center analysis of the incidence of pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy and correlation of the occurrence of pathologic fractures with the course of disease.MATERIALS AND METHODS: One hundred ninety-one patients with multiple myeloma consecutively underwent unenhanced whole-body low-dose MDCT in parallel with hematologic follow-up. Only patients undergoing at least two whole-body low-dose MDCT examinations were included in this retrospective study, resulting in 561 survey intervals. The median analysis period per patient was 23 months (range, 3-53 months). Fracture incidence and the relation between newly occurring fractures and course of the disease were assessed.RESULTS: Forty-nine pathologic fractures were detected in 49 of the 561 survey intervals (8.7%) and in 36 of the 191 patients (19%). Fractures were found on MDCT images irrespective of disease course. They were found in 25 of 202 intervals (12.4%) of progressive disease, in 14 of 171 intervals (8.2%) of disease remission, and in 10 of 188 intervals (5.3%) of stable disease. The overall calculated annual incidence of pathologic fractures in patients with multiple myeloma was 14%. Eleven patients had more than one fracture, all of which were vertebral compression fractures. Three patients had three episodes of bone fracture, and eight patients had two episodes.CONCLUSION: Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy occur independently of myeloma activity and therefore should not be considered a sign of disease progression.",
keywords = "Adult, Aged, Aged, 80 and over, Analysis of Variance, Bone Density Conservation Agents, Chi-Square Distribution, Diphosphonates, Female, Fractures, Spontaneous, Humans, Incidence, Male, Middle Aged, Multiple Myeloma, Radiographic Image Interpretation, Computer-Assisted, Retrospective Studies, Tomography, X-Ray Computed, Journal Article",
author = "Vogel, {Monika N} and Katja Weisel and Olga Maksimovic and Sebastian Peters and Harald Brodoefel and Claussen, {Claus D} and Horger, {Marius S}",
year = "2009",
month = sep,
doi = "10.2214/AJR.08.2002",
language = "English",
volume = "193",
pages = "656--61",
journal = "AM J ROENTGENOL",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "3",

}

RIS

TY - JOUR

T1 - Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy: incidence and correlation with course of disease

AU - Vogel, Monika N

AU - Weisel, Katja

AU - Maksimovic, Olga

AU - Peters, Sebastian

AU - Brodoefel, Harald

AU - Claussen, Claus D

AU - Horger, Marius S

PY - 2009/9

Y1 - 2009/9

N2 - OBJECTIVE: The purposes of this study were single-center analysis of the incidence of pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy and correlation of the occurrence of pathologic fractures with the course of disease.MATERIALS AND METHODS: One hundred ninety-one patients with multiple myeloma consecutively underwent unenhanced whole-body low-dose MDCT in parallel with hematologic follow-up. Only patients undergoing at least two whole-body low-dose MDCT examinations were included in this retrospective study, resulting in 561 survey intervals. The median analysis period per patient was 23 months (range, 3-53 months). Fracture incidence and the relation between newly occurring fractures and course of the disease were assessed.RESULTS: Forty-nine pathologic fractures were detected in 49 of the 561 survey intervals (8.7%) and in 36 of the 191 patients (19%). Fractures were found on MDCT images irrespective of disease course. They were found in 25 of 202 intervals (12.4%) of progressive disease, in 14 of 171 intervals (8.2%) of disease remission, and in 10 of 188 intervals (5.3%) of stable disease. The overall calculated annual incidence of pathologic fractures in patients with multiple myeloma was 14%. Eleven patients had more than one fracture, all of which were vertebral compression fractures. Three patients had three episodes of bone fracture, and eight patients had two episodes.CONCLUSION: Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy occur independently of myeloma activity and therefore should not be considered a sign of disease progression.

AB - OBJECTIVE: The purposes of this study were single-center analysis of the incidence of pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy and correlation of the occurrence of pathologic fractures with the course of disease.MATERIALS AND METHODS: One hundred ninety-one patients with multiple myeloma consecutively underwent unenhanced whole-body low-dose MDCT in parallel with hematologic follow-up. Only patients undergoing at least two whole-body low-dose MDCT examinations were included in this retrospective study, resulting in 561 survey intervals. The median analysis period per patient was 23 months (range, 3-53 months). Fracture incidence and the relation between newly occurring fractures and course of the disease were assessed.RESULTS: Forty-nine pathologic fractures were detected in 49 of the 561 survey intervals (8.7%) and in 36 of the 191 patients (19%). Fractures were found on MDCT images irrespective of disease course. They were found in 25 of 202 intervals (12.4%) of progressive disease, in 14 of 171 intervals (8.2%) of disease remission, and in 10 of 188 intervals (5.3%) of stable disease. The overall calculated annual incidence of pathologic fractures in patients with multiple myeloma was 14%. Eleven patients had more than one fracture, all of which were vertebral compression fractures. Three patients had three episodes of bone fracture, and eight patients had two episodes.CONCLUSION: Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy occur independently of myeloma activity and therefore should not be considered a sign of disease progression.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Analysis of Variance

KW - Bone Density Conservation Agents

KW - Chi-Square Distribution

KW - Diphosphonates

KW - Female

KW - Fractures, Spontaneous

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Multiple Myeloma

KW - Radiographic Image Interpretation, Computer-Assisted

KW - Retrospective Studies

KW - Tomography, X-Ray Computed

KW - Journal Article

U2 - 10.2214/AJR.08.2002

DO - 10.2214/AJR.08.2002

M3 - SCORING: Journal article

C2 - 19696278

VL - 193

SP - 656

EP - 661

JO - AM J ROENTGENOL

JF - AM J ROENTGENOL

SN - 0361-803X

IS - 3

ER -