Patch-based carcinoma detection on confocal laser endomicroscopy images - a cross-site robustness assessment
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Patch-based carcinoma detection on confocal laser endomicroscopy images - a cross-site robustness assessment. / Aubreville, Marc; Goncalves, Miguel; Knipfer, Christian; Oetter, Nicolai; Würfl, Tobias; Neumann, Helmut; Stelzle, Florian; Bohr, Christopher; Maier, Andreas.
In: BIOIMAGING 2018 - 5th International Conference on Bioimaging, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018, 2018, p. 27-34.Research output: SCORING: Contribution to journal › Conference article in journal › Research › peer-review
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TY - JOUR
T1 - Patch-based carcinoma detection on confocal laser endomicroscopy images - a cross-site robustness assessment
AU - Aubreville, Marc
AU - Goncalves, Miguel
AU - Knipfer, Christian
AU - Oetter, Nicolai
AU - Würfl, Tobias
AU - Neumann, Helmut
AU - Stelzle, Florian
AU - Bohr, Christopher
AU - Maier, Andreas
PY - 2018
Y1 - 2018
N2 - Deep learning technologies such as convolutional neural networks (CNN) provide powerful methods for image recognition and have recently been employed in the field of automated carcinoma detection in confocal laser endomicroscopy (CLE) images. CLE is a (sub-)surface microscopic imaging technique that reaches magnifications of up to 1000x and is thus suitable for in vivo structural tissue analysis. In this work, we aim to evaluate the prospects of a priorly developed deep learning-based algorithm targeted at the identification of oral squamous cell carcinoma with regard to its generalization to further anatomic locations of squamous cell carcinomas in the area of head and neck. We applied the algorithm on images acquired from the vocal fold area of five patients with histologically verified squamous cell carcinoma and presumably healthy control images of the clinically normal contra-lateral vocal cord. We find that the network trained on the oral cavity data reaches an accuracy of 89.45% and an area-under-the-curve (AUC) value of 0.955, when applied on the vocal cords data. Compared to the state of the art, we achieve very similar results, yet with an algorithm that was trained on a completely disjunct data set. Concatenating both data sets yielded further improvements in cross-validation with an accuracy of 90.81% and AUC of 0.970. In this study, for the first time to our knowledge, a deep learning mechanism for the identification of oral carcinomas using CLE Images could be applied to other disciplines in the area of head and neck. This study shows the prospect of the algorithmic approach to generalize well on other malignant entities of the head and neck, regardless of the anatomical location and furthermore in an examiner-independent manner.
AB - Deep learning technologies such as convolutional neural networks (CNN) provide powerful methods for image recognition and have recently been employed in the field of automated carcinoma detection in confocal laser endomicroscopy (CLE) images. CLE is a (sub-)surface microscopic imaging technique that reaches magnifications of up to 1000x and is thus suitable for in vivo structural tissue analysis. In this work, we aim to evaluate the prospects of a priorly developed deep learning-based algorithm targeted at the identification of oral squamous cell carcinoma with regard to its generalization to further anatomic locations of squamous cell carcinomas in the area of head and neck. We applied the algorithm on images acquired from the vocal fold area of five patients with histologically verified squamous cell carcinoma and presumably healthy control images of the clinically normal contra-lateral vocal cord. We find that the network trained on the oral cavity data reaches an accuracy of 89.45% and an area-under-the-curve (AUC) value of 0.955, when applied on the vocal cords data. Compared to the state of the art, we achieve very similar results, yet with an algorithm that was trained on a completely disjunct data set. Concatenating both data sets yielded further improvements in cross-validation with an accuracy of 90.81% and AUC of 0.970. In this study, for the first time to our knowledge, a deep learning mechanism for the identification of oral carcinomas using CLE Images could be applied to other disciplines in the area of head and neck. This study shows the prospect of the algorithmic approach to generalize well on other malignant entities of the head and neck, regardless of the anatomical location and furthermore in an examiner-independent manner.
KW - Automatic Carcinoma Detection
KW - Confocal Laser Endomicroscopy
KW - Deep Convolutional Networks
KW - Squamous Cell Carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85051722163&partnerID=8YFLogxK
U2 - 10.5220/0006534700270034
DO - 10.5220/0006534700270034
M3 - Conference article in journal
AN - SCOPUS:85051722163
SP - 27
EP - 34
T2 - 5th International Conference on Bioimaging, BIOIMAGING 2018 - Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018
Y2 - 19 January 2018 through 21 January 2018
ER -