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Particle characterisation and cytokine expression in failed small-diameter metal-on-metal total hip arthroplasties

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Particle characterisation and cytokine expression in failed small-diameter metal-on-metal total hip arthroplasties. / Singh, G; Nuechtern, J V; Meyer, H; Fiedler, G M; Awiszus, F; Junk-Jantsch, S; Bruegel, M; Pflueger, G; Lohmann, C H.

In: BONE JOINT J, Vol. 97-B, No. 7, 07.2015, p. 917-23.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Singh, G, Nuechtern, JV, Meyer, H, Fiedler, GM, Awiszus, F, Junk-Jantsch, S, Bruegel, M, Pflueger, G & Lohmann, CH 2015, 'Particle characterisation and cytokine expression in failed small-diameter metal-on-metal total hip arthroplasties', BONE JOINT J, vol. 97-B, no. 7, pp. 917-23. https://doi.org/10.1302/0301-620X.97B7.35163

APA

Singh, G., Nuechtern, J. V., Meyer, H., Fiedler, G. M., Awiszus, F., Junk-Jantsch, S., Bruegel, M., Pflueger, G., & Lohmann, C. H. (2015). Particle characterisation and cytokine expression in failed small-diameter metal-on-metal total hip arthroplasties. BONE JOINT J, 97-B(7), 917-23. https://doi.org/10.1302/0301-620X.97B7.35163

Vancouver

Singh G, Nuechtern JV, Meyer H, Fiedler GM, Awiszus F, Junk-Jantsch S et al. Particle characterisation and cytokine expression in failed small-diameter metal-on-metal total hip arthroplasties. BONE JOINT J. 2015 Jul;97-B(7):917-23. https://doi.org/10.1302/0301-620X.97B7.35163

Bibtex

@article{2e7a622b0ff8498586287955ccbad77f,
title = "Particle characterisation and cytokine expression in failed small-diameter metal-on-metal total hip arthroplasties",
abstract = "The peri-prosthetic tissue response to wear debris is complex and influenced by various factors including the size, area and number of particles. We hypothesised that the 'biologically active area' of all metal wear particles may predict the type of peri-prosthetic tissue response. Peri-prosthetic tissue was sampled from 21 patients undergoing revision of a small diameter metal-on-metal (MoM) total hip arthroplasty (THA) for aseptic loosening. An enzymatic protocol was used for tissue digestion and scanning electron microscope was used to characterise particles. Equivalent circle diameters and particle areas were calculated. Histomorphometric analyses were performed on all tissue specimens. Aspirates of synovial fluid were collected for analysis of the cytokine profile analysis, and compared with a control group of patients undergoing primary THA (n = 11) and revision of a failed ceramic-on-polyethylene arthroplasty (n = 6). The overall distribution of the size and area of the particles in both lymphocyte and non-lymphocyte-dominated responses were similar; however, the subgroup with lymphocyte-dominated peri-prosthetic tissue responses had a significantly larger total number of particles. 14 cytokines (interleukin (IL)-1{\ss}, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, interferon (IFN)-γ, and IFN-gamma-inducible protein 10), chemokines (macrophage inflammatory protein (MIP)-1α and MIP-1{\ss}), and growth factors (granulocyte macrophage colony stimulating factor (GM-CSF) and platelet derived growth factor) were detected at significantly higher levels in patients with metal wear debris compared with the control group. Significantly higher levels for IL-1{\ss}, IL-5, IL-10 and GM-CSF were found in the subgroup of tissues from failed MoM THAs with a lymphocyte-dominated peri-prosthetic response compared with those without this response. These results suggest that the 'biologically active area' predicts the type of peri-prosthetic tissue response. The cytokines IL-1{\ss}, IL-5, IL-10, and GM-CSF are associated with lymphocyte-dominated tissue responses from failed small-diameter MoM THA.",
keywords = "Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, Cytokines, Female, Hip Prosthesis, Humans, Lymphocytes, Male, Metal-on-Metal Joint Prostheses, Middle Aged, Particle Size, Prosthesis Design, Prosthesis Failure",
author = "G Singh and Nuechtern, {J V} and H Meyer and Fiedler, {G M} and F Awiszus and S Junk-Jantsch and M Bruegel and G Pflueger and Lohmann, {C H}",
note = "{\textcopyright}2015 The British Editorial Society of Bone & Joint Surgery.",
year = "2015",
month = jul,
doi = "10.1302/0301-620X.97B7.35163",
language = "English",
volume = "97-B",
pages = "917--23",
journal = "BONE JOINT J",
issn = "2049-4394",
publisher = "British Editorial Society of Bone and Joint Surgery",
number = "7",

}

RIS

TY - JOUR

T1 - Particle characterisation and cytokine expression in failed small-diameter metal-on-metal total hip arthroplasties

AU - Singh, G

AU - Nuechtern, J V

AU - Meyer, H

AU - Fiedler, G M

AU - Awiszus, F

AU - Junk-Jantsch, S

AU - Bruegel, M

AU - Pflueger, G

AU - Lohmann, C H

N1 - ©2015 The British Editorial Society of Bone & Joint Surgery.

PY - 2015/7

Y1 - 2015/7

N2 - The peri-prosthetic tissue response to wear debris is complex and influenced by various factors including the size, area and number of particles. We hypothesised that the 'biologically active area' of all metal wear particles may predict the type of peri-prosthetic tissue response. Peri-prosthetic tissue was sampled from 21 patients undergoing revision of a small diameter metal-on-metal (MoM) total hip arthroplasty (THA) for aseptic loosening. An enzymatic protocol was used for tissue digestion and scanning electron microscope was used to characterise particles. Equivalent circle diameters and particle areas were calculated. Histomorphometric analyses were performed on all tissue specimens. Aspirates of synovial fluid were collected for analysis of the cytokine profile analysis, and compared with a control group of patients undergoing primary THA (n = 11) and revision of a failed ceramic-on-polyethylene arthroplasty (n = 6). The overall distribution of the size and area of the particles in both lymphocyte and non-lymphocyte-dominated responses were similar; however, the subgroup with lymphocyte-dominated peri-prosthetic tissue responses had a significantly larger total number of particles. 14 cytokines (interleukin (IL)-1ß, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, interferon (IFN)-γ, and IFN-gamma-inducible protein 10), chemokines (macrophage inflammatory protein (MIP)-1α and MIP-1ß), and growth factors (granulocyte macrophage colony stimulating factor (GM-CSF) and platelet derived growth factor) were detected at significantly higher levels in patients with metal wear debris compared with the control group. Significantly higher levels for IL-1ß, IL-5, IL-10 and GM-CSF were found in the subgroup of tissues from failed MoM THAs with a lymphocyte-dominated peri-prosthetic response compared with those without this response. These results suggest that the 'biologically active area' predicts the type of peri-prosthetic tissue response. The cytokines IL-1ß, IL-5, IL-10, and GM-CSF are associated with lymphocyte-dominated tissue responses from failed small-diameter MoM THA.

AB - The peri-prosthetic tissue response to wear debris is complex and influenced by various factors including the size, area and number of particles. We hypothesised that the 'biologically active area' of all metal wear particles may predict the type of peri-prosthetic tissue response. Peri-prosthetic tissue was sampled from 21 patients undergoing revision of a small diameter metal-on-metal (MoM) total hip arthroplasty (THA) for aseptic loosening. An enzymatic protocol was used for tissue digestion and scanning electron microscope was used to characterise particles. Equivalent circle diameters and particle areas were calculated. Histomorphometric analyses were performed on all tissue specimens. Aspirates of synovial fluid were collected for analysis of the cytokine profile analysis, and compared with a control group of patients undergoing primary THA (n = 11) and revision of a failed ceramic-on-polyethylene arthroplasty (n = 6). The overall distribution of the size and area of the particles in both lymphocyte and non-lymphocyte-dominated responses were similar; however, the subgroup with lymphocyte-dominated peri-prosthetic tissue responses had a significantly larger total number of particles. 14 cytokines (interleukin (IL)-1ß, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, interferon (IFN)-γ, and IFN-gamma-inducible protein 10), chemokines (macrophage inflammatory protein (MIP)-1α and MIP-1ß), and growth factors (granulocyte macrophage colony stimulating factor (GM-CSF) and platelet derived growth factor) were detected at significantly higher levels in patients with metal wear debris compared with the control group. Significantly higher levels for IL-1ß, IL-5, IL-10 and GM-CSF were found in the subgroup of tissues from failed MoM THAs with a lymphocyte-dominated peri-prosthetic response compared with those without this response. These results suggest that the 'biologically active area' predicts the type of peri-prosthetic tissue response. The cytokines IL-1ß, IL-5, IL-10, and GM-CSF are associated with lymphocyte-dominated tissue responses from failed small-diameter MoM THA.

KW - Aged

KW - Aged, 80 and over

KW - Arthroplasty, Replacement, Hip

KW - Cytokines

KW - Female

KW - Hip Prosthesis

KW - Humans

KW - Lymphocytes

KW - Male

KW - Metal-on-Metal Joint Prostheses

KW - Middle Aged

KW - Particle Size

KW - Prosthesis Design

KW - Prosthesis Failure

U2 - 10.1302/0301-620X.97B7.35163

DO - 10.1302/0301-620X.97B7.35163

M3 - SCORING: Journal article

C2 - 26130346

VL - 97-B

SP - 917

EP - 923

JO - BONE JOINT J

JF - BONE JOINT J

SN - 2049-4394

IS - 7

ER -