Pain and neurodevelopmental outcomes of infants born very preterm
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Pain and neurodevelopmental outcomes of infants born very preterm. / Giordano, Vito; Deindl, Philipp; Gal, Elisabeth; Unterasinger, Lukas; Fuiko, Renate; Steinbauer, Philipp; Weninger, Manfred; Berger, Angelika; Olischar, Monika.
In: DEV MED CHILD NEUROL, Vol. 65, No. 8, 08.2023, p. 1043-1052.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Pain and neurodevelopmental outcomes of infants born very preterm
AU - Giordano, Vito
AU - Deindl, Philipp
AU - Gal, Elisabeth
AU - Unterasinger, Lukas
AU - Fuiko, Renate
AU - Steinbauer, Philipp
AU - Weninger, Manfred
AU - Berger, Angelika
AU - Olischar, Monika
N1 - © 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.
PY - 2023/8
Y1 - 2023/8
N2 - AIM: To investigate the impact of the level of pain experienced by infants born preterm on neurodevelopmental outcomes during their stay in a neonatal intensive care unit.METHOD: In this retrospective data analysis we included all surviving infants born preterm with a gestational age between 23 and 32 weeks from 2011 to 2015, who were assessed using the Neonatal Pain, Agitation, and Sedation Scale and examined at 1 year of age using the Bayley Scales of Infant Development. We excluded all infants who had suffered severe neurological morbidities and undergone surgical interventions.RESULTS: A total of 196 infants born preterm were included in the analyses: 105 in the 'no pain group' and 91 in the 'pain group'. Significant differences between the groups were detected for both mental and motor development (p = 0.003, 95% confidence interval [CI] 2.23-10.92; p = 0.025, 95% CI 0.64-9.78). The results remained significant after controlling for other important medical conditions (p = 0.001, 95% CI -19.65 to -5.40; p = 0.010, 95% CI -16.18 to -2.29).INTERPRETATION: Neonatal pain exposure was associated with altered neurodevelopmental outcomes of infants born very preterm at a corrected age of 12 months. This observation highlights the importance of adequate pain management to reduce the risk of poor neurodevelopmental outcomes in these vulnerable patients.
AB - AIM: To investigate the impact of the level of pain experienced by infants born preterm on neurodevelopmental outcomes during their stay in a neonatal intensive care unit.METHOD: In this retrospective data analysis we included all surviving infants born preterm with a gestational age between 23 and 32 weeks from 2011 to 2015, who were assessed using the Neonatal Pain, Agitation, and Sedation Scale and examined at 1 year of age using the Bayley Scales of Infant Development. We excluded all infants who had suffered severe neurological morbidities and undergone surgical interventions.RESULTS: A total of 196 infants born preterm were included in the analyses: 105 in the 'no pain group' and 91 in the 'pain group'. Significant differences between the groups were detected for both mental and motor development (p = 0.003, 95% confidence interval [CI] 2.23-10.92; p = 0.025, 95% CI 0.64-9.78). The results remained significant after controlling for other important medical conditions (p = 0.001, 95% CI -19.65 to -5.40; p = 0.010, 95% CI -16.18 to -2.29).INTERPRETATION: Neonatal pain exposure was associated with altered neurodevelopmental outcomes of infants born very preterm at a corrected age of 12 months. This observation highlights the importance of adequate pain management to reduce the risk of poor neurodevelopmental outcomes in these vulnerable patients.
U2 - 10.1111/dmcn.15505
DO - 10.1111/dmcn.15505
M3 - SCORING: Journal article
C2 - 36647629
VL - 65
SP - 1043
EP - 1052
JO - DEV MED CHILD NEUROL
JF - DEV MED CHILD NEUROL
SN - 0012-1622
IS - 8
ER -
