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P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region

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P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region. / Gröbe, Alexander; Hanken, Henning; Al-Dam, Ahmed; Cachovan, Georg; Smeets, Ralf; Krohn, Antje; Clauditz, Till; Grob, Tobias; Simon, Ronald; Sauter, Guido; Kluwe, Lan; Heiland, Max; Blessmann, Marco.

In: CLIN ORAL INVEST, Vol. 18, No. 1, 2014, p. 211-217.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gröbe, A, Hanken, H, Al-Dam, A, Cachovan, G, Smeets, R, Krohn, A, Clauditz, T, Grob, T, Simon, R, Sauter, G, Kluwe, L, Heiland, M & Blessmann, M 2014, 'P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region', CLIN ORAL INVEST, vol. 18, no. 1, pp. 211-217. https://doi.org/10.1007/s00784-013-0939-x

APA

Gröbe, A., Hanken, H., Al-Dam, A., Cachovan, G., Smeets, R., Krohn, A., Clauditz, T., Grob, T., Simon, R., Sauter, G., Kluwe, L., Heiland, M., & Blessmann, M. (2014). P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region. CLIN ORAL INVEST, 18(1), 211-217. https://doi.org/10.1007/s00784-013-0939-x

Vancouver

Gröbe A, Hanken H, Al-Dam A, Cachovan G, Smeets R, Krohn A et al. P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region. CLIN ORAL INVEST. 2014;18(1):211-217. https://doi.org/10.1007/s00784-013-0939-x

Bibtex

@article{d5df77ce0d824908877908183af85d80,
title = "P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region",
abstract = "OBJECTIVES: The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination.MATERIALS AND METHODS: Sections made from two tissue arrays composed of 222 oral squamous cell carcinomas and 427 squamous cell carcinomas of the head and neck region, respectively, were examined for p53 expression and Ki-67 index by means of immunohistochemistry. Correlation of long-term clinical findings of the patients and pathological features of tumours with laboratory results were examined statistically.RESULTS: No significant correlation was found between the p53 immunohistochemical expression in the 207 oral carcinomas and features of the tumours and patient outcomes. There was no significant association between the Ki-67 labelling index and the p53 expression.DISCUSSION: Our failure in detecting any association of the p53 immunohistochemical expression regardless of HPV status with clinical features of these tumours suggests it lacks a prognostic value for squamous cell carcinomas of the oral cavity.CLINICAL RELEVANCE: The prognostic value of p53 immunostaining in oral squamous carcinoma is not clarified yet. In the present study, there is no impact on any prognostical item nor even a correlation with cell proliferation (Ki-67) regardless of HPV status.",
author = "Alexander Gr{\"o}be and Henning Hanken and Ahmed Al-Dam and Georg Cachovan and Ralf Smeets and Antje Krohn and Till Clauditz and Tobias Grob and Ronald Simon and Guido Sauter and Lan Kluwe and Max Heiland and Marco Blessmann",
year = "2014",
doi = "10.1007/s00784-013-0939-x",
language = "English",
volume = "18",
pages = "211--217",
journal = "CLIN ORAL INVEST",
issn = "1432-6981",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region

AU - Gröbe, Alexander

AU - Hanken, Henning

AU - Al-Dam, Ahmed

AU - Cachovan, Georg

AU - Smeets, Ralf

AU - Krohn, Antje

AU - Clauditz, Till

AU - Grob, Tobias

AU - Simon, Ronald

AU - Sauter, Guido

AU - Kluwe, Lan

AU - Heiland, Max

AU - Blessmann, Marco

PY - 2014

Y1 - 2014

N2 - OBJECTIVES: The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination.MATERIALS AND METHODS: Sections made from two tissue arrays composed of 222 oral squamous cell carcinomas and 427 squamous cell carcinomas of the head and neck region, respectively, were examined for p53 expression and Ki-67 index by means of immunohistochemistry. Correlation of long-term clinical findings of the patients and pathological features of tumours with laboratory results were examined statistically.RESULTS: No significant correlation was found between the p53 immunohistochemical expression in the 207 oral carcinomas and features of the tumours and patient outcomes. There was no significant association between the Ki-67 labelling index and the p53 expression.DISCUSSION: Our failure in detecting any association of the p53 immunohistochemical expression regardless of HPV status with clinical features of these tumours suggests it lacks a prognostic value for squamous cell carcinomas of the oral cavity.CLINICAL RELEVANCE: The prognostic value of p53 immunostaining in oral squamous carcinoma is not clarified yet. In the present study, there is no impact on any prognostical item nor even a correlation with cell proliferation (Ki-67) regardless of HPV status.

AB - OBJECTIVES: The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination.MATERIALS AND METHODS: Sections made from two tissue arrays composed of 222 oral squamous cell carcinomas and 427 squamous cell carcinomas of the head and neck region, respectively, were examined for p53 expression and Ki-67 index by means of immunohistochemistry. Correlation of long-term clinical findings of the patients and pathological features of tumours with laboratory results were examined statistically.RESULTS: No significant correlation was found between the p53 immunohistochemical expression in the 207 oral carcinomas and features of the tumours and patient outcomes. There was no significant association between the Ki-67 labelling index and the p53 expression.DISCUSSION: Our failure in detecting any association of the p53 immunohistochemical expression regardless of HPV status with clinical features of these tumours suggests it lacks a prognostic value for squamous cell carcinomas of the oral cavity.CLINICAL RELEVANCE: The prognostic value of p53 immunostaining in oral squamous carcinoma is not clarified yet. In the present study, there is no impact on any prognostical item nor even a correlation with cell proliferation (Ki-67) regardless of HPV status.

U2 - 10.1007/s00784-013-0939-x

DO - 10.1007/s00784-013-0939-x

M3 - SCORING: Journal article

C2 - 23404560

VL - 18

SP - 211

EP - 217

JO - CLIN ORAL INVEST

JF - CLIN ORAL INVEST

SN - 1432-6981

IS - 1

ER -