Research ExplorerPublicationsp53 Alterationen und HPV Status in oralen Plattenepithelkarz...

p53 Alterationen und HPV Status in oralen Plattenepithelkarzinomen

Standard

p53 Alterationen und HPV Status in oralen Plattenepithelkarzinomen. / Barten, M; Ostwald, C; Müller, P; Löning, T; Milde-Langosch, K; Wukasch, Y.

In: Verh Dtsch Ges Pathol, Vol. 78, 1994, p. 255-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Barten, M, Ostwald, C, Müller, P, Löning, T, Milde-Langosch, K & Wukasch, Y 1994, 'p53 Alterationen und HPV Status in oralen Plattenepithelkarzinomen', Verh Dtsch Ges Pathol, vol. 78, pp. 255-9.

APA

Barten, M., Ostwald, C., Müller, P., Löning, T., Milde-Langosch, K., & Wukasch, Y. (1994). p53 Alterationen und HPV Status in oralen Plattenepithelkarzinomen. Verh Dtsch Ges Pathol, 78, 255-9.

Vancouver

Barten M, Ostwald C, Müller P, Löning T, Milde-Langosch K, Wukasch Y. p53 Alterationen und HPV Status in oralen Plattenepithelkarzinomen. Verh Dtsch Ges Pathol. 1994;78:255-9.

Bibtex

@article{42337fc7ba1d420c82dc6363b6320313,
title = "p53 Alterationen und HPV Status in oralen Plattenepithelkarzinomen",
abstract = "Immunohistochemical examination of p53 protein accumulation, analysis of the p53 gene using amplification of the exons 5-8 followed by TGGE, and PCR based HPV typing were carried out on 40 oral squamous cell carcinomas. 28 of 40 oral carcinomas (70%) contained DNA of the oncogenic HPV types 16 and 18. A p53 accumulation was present in 20 of 37 tumors (54%). Mutations of the p53 gene were detected in 15 of 39 carcinomas (38%). 15 of 20 oral carcinomas with abnormal p53 expression and 11/15 tumors with mutations of the p53 gene were HPV positive. Our results demonstrate a frequent occurrence of p53 abnormalities in HPV positive oral squamous cell carcinomas. This pattern is divergent from HPV related genital carcinomas and could reflect differences in the etiology of squamous cell carcinomas of different sites.",
keywords = "Biopsy, Carcinoma, Squamous Cell, DNA Mutational Analysis, DNA, Neoplasm, DNA, Viral, Exons, Genes, p53, Humans, Immunohistochemistry, Mouth Neoplasms, Papillomaviridae, Point Mutation, Polymerase Chain Reaction",
author = "M Barten and C Ostwald and P M{\"u}ller and T L{\"o}ning and K Milde-Langosch and Y Wukasch",
year = "1994",
language = "Deutsch",
volume = "78",
pages = "255--9",

}

RIS

TY - JOUR

T1 - p53 Alterationen und HPV Status in oralen Plattenepithelkarzinomen

AU - Barten, M

AU - Ostwald, C

AU - Müller, P

AU - Löning, T

AU - Milde-Langosch, K

AU - Wukasch, Y

PY - 1994

Y1 - 1994

N2 - Immunohistochemical examination of p53 protein accumulation, analysis of the p53 gene using amplification of the exons 5-8 followed by TGGE, and PCR based HPV typing were carried out on 40 oral squamous cell carcinomas. 28 of 40 oral carcinomas (70%) contained DNA of the oncogenic HPV types 16 and 18. A p53 accumulation was present in 20 of 37 tumors (54%). Mutations of the p53 gene were detected in 15 of 39 carcinomas (38%). 15 of 20 oral carcinomas with abnormal p53 expression and 11/15 tumors with mutations of the p53 gene were HPV positive. Our results demonstrate a frequent occurrence of p53 abnormalities in HPV positive oral squamous cell carcinomas. This pattern is divergent from HPV related genital carcinomas and could reflect differences in the etiology of squamous cell carcinomas of different sites.

AB - Immunohistochemical examination of p53 protein accumulation, analysis of the p53 gene using amplification of the exons 5-8 followed by TGGE, and PCR based HPV typing were carried out on 40 oral squamous cell carcinomas. 28 of 40 oral carcinomas (70%) contained DNA of the oncogenic HPV types 16 and 18. A p53 accumulation was present in 20 of 37 tumors (54%). Mutations of the p53 gene were detected in 15 of 39 carcinomas (38%). 15 of 20 oral carcinomas with abnormal p53 expression and 11/15 tumors with mutations of the p53 gene were HPV positive. Our results demonstrate a frequent occurrence of p53 abnormalities in HPV positive oral squamous cell carcinomas. This pattern is divergent from HPV related genital carcinomas and could reflect differences in the etiology of squamous cell carcinomas of different sites.

KW - Biopsy

KW - Carcinoma, Squamous Cell

KW - DNA Mutational Analysis

KW - DNA, Neoplasm

KW - DNA, Viral

KW - Exons

KW - Genes, p53

KW - Humans

KW - Immunohistochemistry

KW - Mouth Neoplasms

KW - Papillomaviridae

KW - Point Mutation

KW - Polymerase Chain Reaction

M3 - SCORING: Zeitschriftenaufsatz

C2 - 7533995

VL - 78

SP - 255

EP - 259

ER -