P300 in obsessive-compulsive disorder: source localization and the effects of treatment

Christina Andreou; Gregor Leicht; Vlad Popescu; Oliver Pogarell; Paraskevi Mavrogiorgou; Dan Rujescu; Ina Giegling; Michael Zaudig; Georg Juckel; Ulrich Hegerl; Christoph Mulert

doi:10.1016/j.jpsychires.2013.09.003

P300 in obsessive-compulsive disorder: source localization and the effects of treatment

Standard

P300 in obsessive-compulsive disorder: source localization and the effects of treatment. / Andreou, Christina; Leicht, Gregor; Popescu, Vlad; Pogarell, Oliver; Mavrogiorgou, Paraskevi; Rujescu, Dan; Giegling, Ina; Zaudig, Michael; Juckel, Georg; Hegerl, Ulrich; Mulert, Christoph.

In: J PSYCHIATR RES, Vol. 47, No. 12, 01.12.2013, p. 1975-83.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Andreou, C, Leicht, G, Popescu, V, Pogarell, O, Mavrogiorgou, P, Rujescu, D, Giegling, I, Zaudig, M, Juckel, G, Hegerl, U & Mulert, C 2013, 'P300 in obsessive-compulsive disorder: source localization and the effects of treatment', J PSYCHIATR RES, vol. 47, no. 12, pp. 1975-83. https://doi.org/10.1016/j.jpsychires.2013.09.003

APA

Andreou, C., Leicht, G., Popescu, V., Pogarell, O., Mavrogiorgou, P., Rujescu, D., Giegling, I., Zaudig, M., Juckel, G., Hegerl, U., & Mulert, C. (2013). P300 in obsessive-compulsive disorder: source localization and the effects of treatment. J PSYCHIATR RES, 47(12), 1975-83. https://doi.org/10.1016/j.jpsychires.2013.09.003

Vancouver

Andreou C, Leicht G, Popescu V, Pogarell O, Mavrogiorgou P, Rujescu D et al. P300 in obsessive-compulsive disorder: source localization and the effects of treatment. J PSYCHIATR RES. 2013 Dec 1;47(12):1975-83. https://doi.org/10.1016/j.jpsychires.2013.09.003

Bibtex

@article{9f1a83063a1f4548a4d64415b57ab14f,

title = "P300 in obsessive-compulsive disorder: source localization and the effects of treatment",

abstract = "Converging evidence suggests that frontostriatal abnormalities underlie OCD symptoms. The event-related potential P300 is generated along a widely distributed network involving several of the areas implicated in OCD. P300 abnormalities reported in patients with OCD suggest increased activity in these areas. The aim of the present study was to investigate this assumption in unmedicated patients with OCD, and to assess the effects of OCD treatment on P300 brain activity patterns. Seventy-one unmedicated patients with a DSM-IV diagnosis of OCD and 71 age- and gender-matched healthy control subjects participated in the study. The P300 was obtained through 32-channel EEG during an auditory oddball paradigm. Forty-three patients underwent a second EEG assessment after treatment with sertraline and behavioural therapy. Low-resolution electromagnetic tomography (LORETA) was used to localize the sources of brain electrical activity. Results: Increased P300-related activity was observed predominantly in the left orbitofrontal cortex, but also in left prefrontal, parietal and temporal areas, in patients compared to controls at baseline. After treatment, reduction of left middle frontal cortex hyperactivity was observed in patients. Conclusions: Findings of increased activity in frontoparietal areas in patients are consistent with several previous studies. Importantly, OCD treatment led to reduction of hyperactivity in the left middle frontal cortex, an area associated with context processing and uncertainty that might be important for the emergence of OCD symptoms. Thus, the present study is the first to show an association between P300 abnormalities and activity in brain regions postulated to be involved in the pathophysiology of OCD.",

keywords = "Adolescent, Adult, Antidepressive Agents, Brain Mapping, Case-Control Studies, Cognitive Therapy, Electroencephalography, Event-Related Potentials, P300, Female, Frontal Lobe, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Sertraline, Young Adult",

author = "Christina Andreou and Gregor Leicht and Vlad Popescu and Oliver Pogarell and Paraskevi Mavrogiorgou and Dan Rujescu and Ina Giegling and Michael Zaudig and Georg Juckel and Ulrich Hegerl and Christoph Mulert",

year = "2013",

month = dec,

day = "1",

doi = "10.1016/j.jpsychires.2013.09.003",

language = "English",

volume = "47",

pages = "1975--83",

journal = "J PSYCHIATR RES",

issn = "0022-3956",

publisher = "Elsevier Limited",

number = "12",

}

RIS

TY - JOUR

T1 - P300 in obsessive-compulsive disorder: source localization and the effects of treatment

AU - Andreou, Christina

AU - Leicht, Gregor

AU - Popescu, Vlad

AU - Pogarell, Oliver

AU - Mavrogiorgou, Paraskevi

AU - Rujescu, Dan

AU - Giegling, Ina

AU - Zaudig, Michael

AU - Juckel, Georg

AU - Hegerl, Ulrich

AU - Mulert, Christoph

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Converging evidence suggests that frontostriatal abnormalities underlie OCD symptoms. The event-related potential P300 is generated along a widely distributed network involving several of the areas implicated in OCD. P300 abnormalities reported in patients with OCD suggest increased activity in these areas. The aim of the present study was to investigate this assumption in unmedicated patients with OCD, and to assess the effects of OCD treatment on P300 brain activity patterns. Seventy-one unmedicated patients with a DSM-IV diagnosis of OCD and 71 age- and gender-matched healthy control subjects participated in the study. The P300 was obtained through 32-channel EEG during an auditory oddball paradigm. Forty-three patients underwent a second EEG assessment after treatment with sertraline and behavioural therapy. Low-resolution electromagnetic tomography (LORETA) was used to localize the sources of brain electrical activity. Results: Increased P300-related activity was observed predominantly in the left orbitofrontal cortex, but also in left prefrontal, parietal and temporal areas, in patients compared to controls at baseline. After treatment, reduction of left middle frontal cortex hyperactivity was observed in patients. Conclusions: Findings of increased activity in frontoparietal areas in patients are consistent with several previous studies. Importantly, OCD treatment led to reduction of hyperactivity in the left middle frontal cortex, an area associated with context processing and uncertainty that might be important for the emergence of OCD symptoms. Thus, the present study is the first to show an association between P300 abnormalities and activity in brain regions postulated to be involved in the pathophysiology of OCD.

AB - Converging evidence suggests that frontostriatal abnormalities underlie OCD symptoms. The event-related potential P300 is generated along a widely distributed network involving several of the areas implicated in OCD. P300 abnormalities reported in patients with OCD suggest increased activity in these areas. The aim of the present study was to investigate this assumption in unmedicated patients with OCD, and to assess the effects of OCD treatment on P300 brain activity patterns. Seventy-one unmedicated patients with a DSM-IV diagnosis of OCD and 71 age- and gender-matched healthy control subjects participated in the study. The P300 was obtained through 32-channel EEG during an auditory oddball paradigm. Forty-three patients underwent a second EEG assessment after treatment with sertraline and behavioural therapy. Low-resolution electromagnetic tomography (LORETA) was used to localize the sources of brain electrical activity. Results: Increased P300-related activity was observed predominantly in the left orbitofrontal cortex, but also in left prefrontal, parietal and temporal areas, in patients compared to controls at baseline. After treatment, reduction of left middle frontal cortex hyperactivity was observed in patients. Conclusions: Findings of increased activity in frontoparietal areas in patients are consistent with several previous studies. Importantly, OCD treatment led to reduction of hyperactivity in the left middle frontal cortex, an area associated with context processing and uncertainty that might be important for the emergence of OCD symptoms. Thus, the present study is the first to show an association between P300 abnormalities and activity in brain regions postulated to be involved in the pathophysiology of OCD.

KW - Adolescent

KW - Adult

KW - Antidepressive Agents

KW - Brain Mapping

KW - Case-Control Studies

KW - Cognitive Therapy

KW - Electroencephalography

KW - Event-Related Potentials, P300

KW - Female

KW - Frontal Lobe

KW - Humans

KW - Male

KW - Middle Aged

KW - Obsessive-Compulsive Disorder

KW - Psychiatric Status Rating Scales

KW - Sertraline

KW - Young Adult

U2 - 10.1016/j.jpsychires.2013.09.003

DO - 10.1016/j.jpsychires.2013.09.003

M3 - SCORING: Journal article

C2 - 24075207

VL - 47

SP - 1975

EP - 1983

JO - J PSYCHIATR RES

JF - J PSYCHIATR RES

SN - 0022-3956

IS - 12

ER -