P-105 Glycine attenuates impairments of interhemispheric gamma-band connectivity in the ketamine model of schizophrenia
Related Research units
Abstract
Methods: In a double-blind, randomized, placebo-controlled crossover design, 25 n healthy volunteers were measured using 64-channel-electroencephalography (EEG). Psychopathologic changes were assessed by PANSS and the subjective 5D-ASC questionnaire.
Results: Interhemispheric connectivity analysis were performed using eLORETA source estimation and lagged phase synchronization (LPS) in the gamma-band range (30–100 Hz). Ketamine induced a schizophrenia-like change in laterality of dichotic hearing that could be reversed by glycine-modulation. In addition, interhemispheric gamma-band connectivity was found to be altered both under ketamine and glycine (higher interhemispheric gamma-band connectivity). Pretreatment with glycine normalized the ketamine-induced alterations of interhemispheric connectivity.
Conclusion: These findings argue for an important role of glutamatergic neurotransmission for the interhemispheric communication between bilateral auditory cortices. NMDAR-modulation could help to restore E/I-imbalance causing disturbed auditory perception in schizophrenia.
Bibliographical data
Original language | English |
---|---|
Article number | e56 |
ISSN | 1388-2457 |
DOIs | |
Publication status | Published - 04.2023 |