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Oxytocin attenuates amygdala responses to emotional faces regardless of valence

Standard

Oxytocin attenuates amygdala responses to emotional faces regardless of valence. / Domes, Gregor; Heinrichs, Markus; Gläscher, Jan; Büchel, Christian; Braus, Dieter F; Herpertz, Sabine C.

In: BIOL PSYCHIAT, Vol. 62, No. 10, 15.11.2007, p. 1187-90.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Domes, G, Heinrichs, M, Gläscher, J, Büchel, C, Braus, DF & Herpertz, SC 2007, 'Oxytocin attenuates amygdala responses to emotional faces regardless of valence', BIOL PSYCHIAT, vol. 62, no. 10, pp. 1187-90. https://doi.org/10.1016/j.biopsych.2007.03.025

APA

Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007). Oxytocin attenuates amygdala responses to emotional faces regardless of valence. BIOL PSYCHIAT, 62(10), 1187-90. https://doi.org/10.1016/j.biopsych.2007.03.025

Vancouver

Domes G, Heinrichs M, Gläscher J, Büchel C, Braus DF, Herpertz SC. Oxytocin attenuates amygdala responses to emotional faces regardless of valence. BIOL PSYCHIAT. 2007 Nov 15;62(10):1187-90. https://doi.org/10.1016/j.biopsych.2007.03.025

Bibtex

@article{6a1515c5ae354c30a6d1ceb2894ea430,
title = "Oxytocin attenuates amygdala responses to emotional faces regardless of valence",
abstract = "BACKGROUND: Oxytocin is known to reduce anxiety and stress in social interactions as well as to modulate approach behavior. Recent studies suggest that the amygdala might be the primary neuronal basis for these effects.METHODS: In a functional magnetic resonance imaging study using a double-blind, placebo-controlled within-subject design, we measured neural responses to fearful, angry, and happy facial expressions after intranasal application of 24 IU oxytocin compared with placebo.RESULTS: Oxytocin reduced right-sided amygdala responses to all three face categories even when the emotional content of the presented face was not evaluated explicitly. Exploratory whole brain analysis revealed modulatory effects in prefrontal and temporal areas as well as in the brainstem.CONCLUSIONS: Results suggest a modulatory role of oxytocin on amygdala responses to facial expressions irrespective of their valence. Reduction of amygdala activity to positive and negative stimuli might reflect reduced uncertainty about the predictive value of a social stimulus and thereby facilitates social approach behavior.",
keywords = "Adult, Amygdala, Brain Mapping, Double-Blind Method, Emotions, Facial Expression, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Oxytocin, Pattern Recognition, Visual, Photic Stimulation",
author = "Gregor Domes and Markus Heinrichs and Jan Gl{\"a}scher and Christian B{\"u}chel and Braus, {Dieter F} and Herpertz, {Sabine C}",
year = "2007",
month = nov,
day = "15",
doi = "10.1016/j.biopsych.2007.03.025",
language = "English",
volume = "62",
pages = "1187--90",
journal = "BIOL PSYCHIAT",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "10",

}

RIS

TY - JOUR

T1 - Oxytocin attenuates amygdala responses to emotional faces regardless of valence

AU - Domes, Gregor

AU - Heinrichs, Markus

AU - Gläscher, Jan

AU - Büchel, Christian

AU - Braus, Dieter F

AU - Herpertz, Sabine C

PY - 2007/11/15

Y1 - 2007/11/15

N2 - BACKGROUND: Oxytocin is known to reduce anxiety and stress in social interactions as well as to modulate approach behavior. Recent studies suggest that the amygdala might be the primary neuronal basis for these effects.METHODS: In a functional magnetic resonance imaging study using a double-blind, placebo-controlled within-subject design, we measured neural responses to fearful, angry, and happy facial expressions after intranasal application of 24 IU oxytocin compared with placebo.RESULTS: Oxytocin reduced right-sided amygdala responses to all three face categories even when the emotional content of the presented face was not evaluated explicitly. Exploratory whole brain analysis revealed modulatory effects in prefrontal and temporal areas as well as in the brainstem.CONCLUSIONS: Results suggest a modulatory role of oxytocin on amygdala responses to facial expressions irrespective of their valence. Reduction of amygdala activity to positive and negative stimuli might reflect reduced uncertainty about the predictive value of a social stimulus and thereby facilitates social approach behavior.

AB - BACKGROUND: Oxytocin is known to reduce anxiety and stress in social interactions as well as to modulate approach behavior. Recent studies suggest that the amygdala might be the primary neuronal basis for these effects.METHODS: In a functional magnetic resonance imaging study using a double-blind, placebo-controlled within-subject design, we measured neural responses to fearful, angry, and happy facial expressions after intranasal application of 24 IU oxytocin compared with placebo.RESULTS: Oxytocin reduced right-sided amygdala responses to all three face categories even when the emotional content of the presented face was not evaluated explicitly. Exploratory whole brain analysis revealed modulatory effects in prefrontal and temporal areas as well as in the brainstem.CONCLUSIONS: Results suggest a modulatory role of oxytocin on amygdala responses to facial expressions irrespective of their valence. Reduction of amygdala activity to positive and negative stimuli might reflect reduced uncertainty about the predictive value of a social stimulus and thereby facilitates social approach behavior.

KW - Adult

KW - Amygdala

KW - Brain Mapping

KW - Double-Blind Method

KW - Emotions

KW - Facial Expression

KW - Functional Laterality

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Oxygen

KW - Oxytocin

KW - Pattern Recognition, Visual

KW - Photic Stimulation

U2 - 10.1016/j.biopsych.2007.03.025

DO - 10.1016/j.biopsych.2007.03.025

M3 - SCORING: Journal article

C2 - 17617382

VL - 62

SP - 1187

EP - 1190

JO - BIOL PSYCHIAT

JF - BIOL PSYCHIAT

SN - 0006-3223

IS - 10

ER -