Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings.

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Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings. / Kellner, Michael; Otte, Christian; Yassouridis, Alexander; Schick, Mildred; Jahn, Holger; Wiedemann, Klaus.

In: EUR NEUROPSYCHOPHARM, Vol. 14, No. 4, 4, 2004, p. 337-339.

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@article{fd4157bc1c85423ba659db4f358e5791,
title = "Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings.",
abstract = "Using overnight metyrapone and combined dexamethasone/metyrapone tests, hypothalamic-pituitary-adrenocortical (HPA) axis feedback regulation was characterised in 10 patients with post-traumatic stress disorder (PTSD) and 10 matched healthy comparison subjects. Significant treatment effects of both metyrapone and the combination of dexamethasone and metyrapone were observed for adrenocorticotropic hormone (ACTH), 11-deoxycortisol (11-DOC) and cortisol, but no differences between patients and comparison subjects emerged. Dose-response studies using metyrapone and glucocorticoid agonists are needed to further investigate HPA axis regulation in PTSD.",
author = "Michael Kellner and Christian Otte and Alexander Yassouridis and Mildred Schick and Holger Jahn and Klaus Wiedemann",
year = "2004",
language = "Deutsch",
volume = "14",
pages = "337--339",
journal = "EUR NEUROPSYCHOPHARM",
issn = "0924-977X",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings.

AU - Kellner, Michael

AU - Otte, Christian

AU - Yassouridis, Alexander

AU - Schick, Mildred

AU - Jahn, Holger

AU - Wiedemann, Klaus

PY - 2004

Y1 - 2004

N2 - Using overnight metyrapone and combined dexamethasone/metyrapone tests, hypothalamic-pituitary-adrenocortical (HPA) axis feedback regulation was characterised in 10 patients with post-traumatic stress disorder (PTSD) and 10 matched healthy comparison subjects. Significant treatment effects of both metyrapone and the combination of dexamethasone and metyrapone were observed for adrenocorticotropic hormone (ACTH), 11-deoxycortisol (11-DOC) and cortisol, but no differences between patients and comparison subjects emerged. Dose-response studies using metyrapone and glucocorticoid agonists are needed to further investigate HPA axis regulation in PTSD.

AB - Using overnight metyrapone and combined dexamethasone/metyrapone tests, hypothalamic-pituitary-adrenocortical (HPA) axis feedback regulation was characterised in 10 patients with post-traumatic stress disorder (PTSD) and 10 matched healthy comparison subjects. Significant treatment effects of both metyrapone and the combination of dexamethasone and metyrapone were observed for adrenocorticotropic hormone (ACTH), 11-deoxycortisol (11-DOC) and cortisol, but no differences between patients and comparison subjects emerged. Dose-response studies using metyrapone and glucocorticoid agonists are needed to further investigate HPA axis regulation in PTSD.

M3 - SCORING: Zeitschriftenaufsatz

VL - 14

SP - 337

EP - 339

JO - EUR NEUROPSYCHOPHARM

JF - EUR NEUROPSYCHOPHARM

SN - 0924-977X

IS - 4

M1 - 4

ER -