Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis.

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Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis. / Schramm, Christoph; Lohse, Ansgar W.

In: CLIN REV ALLERG IMMU, Vol. 28, No. 2, 04.2005, p. 105-14.

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@article{66006f115d834980b3933a05183b7904,
title = "Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis.",
abstract = "Approximately 18% of patients with auto-immune liver disease present with features characteristic of a second auto-immune liver disease. These cases have been termed {"}overlap syndromes.{"}The pathogenesis of overlap syndromes is poorly understood, and few data are available regarding the clinical characteristics and outcome of this disease. Therefore, a consensus on the definition of overlap syndromes has not been reached. A common genetic background between auto-immune hepatitis (AIH) and its overlap with primary biliary cirrhosis(PBC) or primary sclerosing cholangitis (PSC) might confer susceptibility to a more inflammatory phenotype, probably requiring combined immunosuppressive treatment. This article focuses on the prevalence, diagnosis, and treatment of the overlap syndrome of AIH and PBC or PSC.",
keywords = "Autoantibodies, Cholagogues and Choleretics, Cholangitis, Sclerosing, Diagnosis, Differential, Hepatitis, Autoimmune, Humans, Liver Cirrhosis, Biliary, Prevalence, Ursodeoxycholic Acid, Journal Article, Review",
author = "Christoph Schramm and Lohse, {Ansgar W}",
year = "2005",
month = apr,
doi = "10.1385/CRIAI:28:2:105",
language = "English",
volume = "28",
pages = "105--14",
journal = "CLIN REV ALLERG IMMU",
issn = "1080-0549",
publisher = "Humana Press",
number = "2",

}

RIS

TY - JOUR

T1 - Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis.

AU - Schramm, Christoph

AU - Lohse, Ansgar W

PY - 2005/4

Y1 - 2005/4

N2 - Approximately 18% of patients with auto-immune liver disease present with features characteristic of a second auto-immune liver disease. These cases have been termed "overlap syndromes."The pathogenesis of overlap syndromes is poorly understood, and few data are available regarding the clinical characteristics and outcome of this disease. Therefore, a consensus on the definition of overlap syndromes has not been reached. A common genetic background between auto-immune hepatitis (AIH) and its overlap with primary biliary cirrhosis(PBC) or primary sclerosing cholangitis (PSC) might confer susceptibility to a more inflammatory phenotype, probably requiring combined immunosuppressive treatment. This article focuses on the prevalence, diagnosis, and treatment of the overlap syndrome of AIH and PBC or PSC.

AB - Approximately 18% of patients with auto-immune liver disease present with features characteristic of a second auto-immune liver disease. These cases have been termed "overlap syndromes."The pathogenesis of overlap syndromes is poorly understood, and few data are available regarding the clinical characteristics and outcome of this disease. Therefore, a consensus on the definition of overlap syndromes has not been reached. A common genetic background between auto-immune hepatitis (AIH) and its overlap with primary biliary cirrhosis(PBC) or primary sclerosing cholangitis (PSC) might confer susceptibility to a more inflammatory phenotype, probably requiring combined immunosuppressive treatment. This article focuses on the prevalence, diagnosis, and treatment of the overlap syndrome of AIH and PBC or PSC.

KW - Autoantibodies

KW - Cholagogues and Choleretics

KW - Cholangitis, Sclerosing

KW - Diagnosis, Differential

KW - Hepatitis, Autoimmune

KW - Humans

KW - Liver Cirrhosis, Biliary

KW - Prevalence

KW - Ursodeoxycholic Acid

KW - Journal Article

KW - Review

U2 - 10.1385/CRIAI:28:2:105

DO - 10.1385/CRIAI:28:2:105

M3 - SCORING: Review article

C2 - 15879617

VL - 28

SP - 105

EP - 114

JO - CLIN REV ALLERG IMMU

JF - CLIN REV ALLERG IMMU

SN - 1080-0549

IS - 2

ER -