Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes.
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Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes. / Rau, Thomas; Nose, Monika; Remmers, Ute; Weil, Joachim; Weissmüller, Astrid; Davia, Kerry; Harding, Sian; Peppel, Karsten; Koch, Walter J; Eschenhagen, Thomas.
In: FASEB J, Vol. 17, No. 3, 3, 2003, p. 523-525.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes.
AU - Rau, Thomas
AU - Nose, Monika
AU - Remmers, Ute
AU - Weil, Joachim
AU - Weissmüller, Astrid
AU - Davia, Kerry
AU - Harding, Sian
AU - Peppel, Karsten
AU - Koch, Walter J
AU - Eschenhagen, Thomas
PY - 2003
Y1 - 2003
N2 - The role of Galpha(i)-2 overexpression in desensitization of beta-adrenergic signaling in heart failure is controversial. An adenovirus-based approach was used to investigate whether overexpression of Galpha(i)-2 impairs beta-adrenergic stimulation of adenylyl cyclase (AC) activity and cAMP levels in neonatal rat cardiac myocytes (NRCM) and cell shortening of adult rat ventricular myocytes (ARVM). Infection of NRCM with Ad5Galpha(i)-2 increased Galpha(i)-2 by 50-600% in a virus dose-dependent manner. Overexpression was paralleled by suppression of GTP- and isoprenaline-stimulated AC by 10-72% (P
AB - The role of Galpha(i)-2 overexpression in desensitization of beta-adrenergic signaling in heart failure is controversial. An adenovirus-based approach was used to investigate whether overexpression of Galpha(i)-2 impairs beta-adrenergic stimulation of adenylyl cyclase (AC) activity and cAMP levels in neonatal rat cardiac myocytes (NRCM) and cell shortening of adult rat ventricular myocytes (ARVM). Infection of NRCM with Ad5Galpha(i)-2 increased Galpha(i)-2 by 50-600% in a virus dose-dependent manner. Overexpression was paralleled by suppression of GTP- and isoprenaline-stimulated AC by 10-72% (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 17
SP - 523
EP - 525
JO - FASEB J
JF - FASEB J
SN - 0892-6638
IS - 3
M1 - 3
ER -