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Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma.

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Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. / Dahl, Anka; Schachner, Melitta; Moll, Ingrid; Berger, Jürgen; Schulze, Hans-Joachim; Brunner, Georg; Schumacher, Udo.

In: EUR J CANCER, Vol. 38, No. 13, 13, 2002, p. 1708-1716.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dahl, A, Schachner, M, Moll, I, Berger, J, Schulze, H-J, Brunner, G & Schumacher, U 2002, 'Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma.', EUR J CANCER, vol. 38, no. 13, 13, pp. 1708-1716. <http://www.ncbi.nlm.nih.gov/pubmed/12175686?dopt=Citation>

APA

Dahl, A., Schachner, M., Moll, I., Berger, J., Schulze, H-J., Brunner, G., & Schumacher, U. (2002). Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. EUR J CANCER, 38(13), 1708-1716. [13]. http://www.ncbi.nlm.nih.gov/pubmed/12175686?dopt=Citation

Vancouver

Dahl A, Schachner M, Moll I, Berger J, Schulze H-J, Brunner G et al. Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. EUR J CANCER. 2002;38(13):1708-1716. 13.

Bibtex

@article{6642aebbb5ac4e8eb27de935c9f665d4,
title = "Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma.",
abstract = "Modulation of cell adhesion molecule expression plays a key role in melanoma metastasis. In particular, the expression of the cell adhesion molecule L1 has been associated with the metastatic phenotype in a murine model of malignant melanoma. However, no such association between L1 expression and metastasis has been investigated in a clinical study. Therefore, L1 expression was determined immunohistochemically in 100 cases of malignant melanoma and correlated with metastasis in a 10-year retrospective study. Furthermore, nine distant metastases and five sentinel lymph node metastases were analysed for their L1 expression. Additionally, the expression of alpha2,3 sialic acid residues, which are recognised by the siglec domain of L1, was determined by Maackia amurensis agglutinin (MAA) lectin histochemistry. The log-rank test between Kaplan-Meier curves revealed a positive association between L1 expression and metastasis (P",
author = "Anka Dahl and Melitta Schachner and Ingrid Moll and J{\"u}rgen Berger and Hans-Joachim Schulze and Georg Brunner and Udo Schumacher",
year = "2002",
language = "Deutsch",
volume = "38",
pages = "1708--1716",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "13",

}

RIS

TY - JOUR

T1 - Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma.

AU - Dahl, Anka

AU - Schachner, Melitta

AU - Moll, Ingrid

AU - Berger, Jürgen

AU - Schulze, Hans-Joachim

AU - Brunner, Georg

AU - Schumacher, Udo

PY - 2002

Y1 - 2002

N2 - Modulation of cell adhesion molecule expression plays a key role in melanoma metastasis. In particular, the expression of the cell adhesion molecule L1 has been associated with the metastatic phenotype in a murine model of malignant melanoma. However, no such association between L1 expression and metastasis has been investigated in a clinical study. Therefore, L1 expression was determined immunohistochemically in 100 cases of malignant melanoma and correlated with metastasis in a 10-year retrospective study. Furthermore, nine distant metastases and five sentinel lymph node metastases were analysed for their L1 expression. Additionally, the expression of alpha2,3 sialic acid residues, which are recognised by the siglec domain of L1, was determined by Maackia amurensis agglutinin (MAA) lectin histochemistry. The log-rank test between Kaplan-Meier curves revealed a positive association between L1 expression and metastasis (P

AB - Modulation of cell adhesion molecule expression plays a key role in melanoma metastasis. In particular, the expression of the cell adhesion molecule L1 has been associated with the metastatic phenotype in a murine model of malignant melanoma. However, no such association between L1 expression and metastasis has been investigated in a clinical study. Therefore, L1 expression was determined immunohistochemically in 100 cases of malignant melanoma and correlated with metastasis in a 10-year retrospective study. Furthermore, nine distant metastases and five sentinel lymph node metastases were analysed for their L1 expression. Additionally, the expression of alpha2,3 sialic acid residues, which are recognised by the siglec domain of L1, was determined by Maackia amurensis agglutinin (MAA) lectin histochemistry. The log-rank test between Kaplan-Meier curves revealed a positive association between L1 expression and metastasis (P

M3 - SCORING: Zeitschriftenaufsatz

VL - 38

SP - 1708

EP - 1716

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 13

M1 - 13

ER -