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Outcomes of Ventral Onlay Buccal Mucosa Graft Urethroplasty in Patients after Radiotherapy

Standard

Outcomes of Ventral Onlay Buccal Mucosa Graft Urethroplasty in Patients after Radiotherapy. / Ahyai, Sascha A; Schmid, Marianne; Kuhl, Marie; Kluth, Luis A; Soave, Armin; Riechardt, Silke; Chun, Felix K-H; Engel, Oliver; Fisch, Margit; Dahlem, Roland.

In: J UROLOGY, Vol. 194, No. 2, 08.2015, p. 441-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ahyai, SA, Schmid, M, Kuhl, M, Kluth, LA, Soave, A, Riechardt, S, Chun, FK-H, Engel, O, Fisch, M & Dahlem, R 2015, 'Outcomes of Ventral Onlay Buccal Mucosa Graft Urethroplasty in Patients after Radiotherapy', J UROLOGY, vol. 194, no. 2, pp. 441-6. https://doi.org/10.1016/j.juro.2015.03.116

APA

Ahyai, S. A., Schmid, M., Kuhl, M., Kluth, L. A., Soave, A., Riechardt, S., Chun, F. K-H., Engel, O., Fisch, M., & Dahlem, R. (2015). Outcomes of Ventral Onlay Buccal Mucosa Graft Urethroplasty in Patients after Radiotherapy. J UROLOGY, 194(2), 441-6. https://doi.org/10.1016/j.juro.2015.03.116

Vancouver

Ahyai SA, Schmid M, Kuhl M, Kluth LA, Soave A, Riechardt S et al. Outcomes of Ventral Onlay Buccal Mucosa Graft Urethroplasty in Patients after Radiotherapy. J UROLOGY. 2015 Aug;194(2):441-6. https://doi.org/10.1016/j.juro.2015.03.116

Bibtex

@article{ab88c1317c644f01a0ad021a350eecff,
title = "Outcomes of Ventral Onlay Buccal Mucosa Graft Urethroplasty in Patients after Radiotherapy",
abstract = "PURPOSE: We evaluated stricture-free survival and functional outcomes of buccal mucosa graft urethroplasty in patients with urethral stricture disease after radiotherapy.MATERIALS AND METHODS: We reviewed our urethroplasty database for patients with a radiotherapy history who underwent buccal mucosa graft urethroplasty between January 2009 and October 2013. We reviewed patient charts and the institutional, standardized, nonvalidated questionnaires administered to each patient postoperatively. Study end points included 1) the success rate, 2) continence status, 3) erectile function and 4) patient satisfaction postoperatively. Success was defined as stricture-free survival.RESULTS: Of 38 men included in the study prostate cancer was the most common indication for radiotherapy in 35 (92.1%). External beam radiotherapy was performed in 24 cases (64.9%), brachytherapy was done in 8 (21.6%) and a combination of the 2 treatments was performed in 6 (13.5%). Strictures were in the bulbar/bulbomembranous urethra and had a median length of 3.0 cm (range 1.0 to 8.0). The overall success rate was 71.1% at a median followup of 26.5 months (range 1.0 to 50.0). Median time to stricture recurrence was 17.0 months (range 3.0 to 44.0). De novo urinary incontinence was observed in 4 patients (10.5%). Erectile function remained mostly unchanged compared to preoperative status. Study limitations include the small sample size and the lack of validated questionnaires.CONCLUSIONS: At short-term to mid-term followup the success rate of ventral onlay buccal mucosa graft urethroplasty in patients with radiotherapy history seems acceptable. However, patients must be counseled about the increased risk of urinary incontinence. Longer followup is warranted to address long-term outcomes.",
keywords = "Adult, Aged, Aged, 80 and over, Disease-Free Survival, Follow-Up Studies, Humans, Male, Middle Aged, Mouth Mucosa, Prostatic Neoplasms, Radiation Injuries, Radiotherapy, Adjuvant, Reconstructive Surgical Procedures, Retrospective Studies, Time Factors, Treatment Outcome, Urethra, Urethral Stricture, Urologic Surgical Procedures, Male",
author = "Ahyai, {Sascha A} and Marianne Schmid and Marie Kuhl and Kluth, {Luis A} and Armin Soave and Silke Riechardt and Chun, {Felix K-H} and Oliver Engel and Margit Fisch and Roland Dahlem",
note = "Copyright {\textcopyright} 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.",
year = "2015",
month = aug,
doi = "10.1016/j.juro.2015.03.116",
language = "English",
volume = "194",
pages = "441--6",
journal = "J UROLOGY",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Outcomes of Ventral Onlay Buccal Mucosa Graft Urethroplasty in Patients after Radiotherapy

AU - Ahyai, Sascha A

AU - Schmid, Marianne

AU - Kuhl, Marie

AU - Kluth, Luis A

AU - Soave, Armin

AU - Riechardt, Silke

AU - Chun, Felix K-H

AU - Engel, Oliver

AU - Fisch, Margit

AU - Dahlem, Roland

N1 - Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2015/8

Y1 - 2015/8

N2 - PURPOSE: We evaluated stricture-free survival and functional outcomes of buccal mucosa graft urethroplasty in patients with urethral stricture disease after radiotherapy.MATERIALS AND METHODS: We reviewed our urethroplasty database for patients with a radiotherapy history who underwent buccal mucosa graft urethroplasty between January 2009 and October 2013. We reviewed patient charts and the institutional, standardized, nonvalidated questionnaires administered to each patient postoperatively. Study end points included 1) the success rate, 2) continence status, 3) erectile function and 4) patient satisfaction postoperatively. Success was defined as stricture-free survival.RESULTS: Of 38 men included in the study prostate cancer was the most common indication for radiotherapy in 35 (92.1%). External beam radiotherapy was performed in 24 cases (64.9%), brachytherapy was done in 8 (21.6%) and a combination of the 2 treatments was performed in 6 (13.5%). Strictures were in the bulbar/bulbomembranous urethra and had a median length of 3.0 cm (range 1.0 to 8.0). The overall success rate was 71.1% at a median followup of 26.5 months (range 1.0 to 50.0). Median time to stricture recurrence was 17.0 months (range 3.0 to 44.0). De novo urinary incontinence was observed in 4 patients (10.5%). Erectile function remained mostly unchanged compared to preoperative status. Study limitations include the small sample size and the lack of validated questionnaires.CONCLUSIONS: At short-term to mid-term followup the success rate of ventral onlay buccal mucosa graft urethroplasty in patients with radiotherapy history seems acceptable. However, patients must be counseled about the increased risk of urinary incontinence. Longer followup is warranted to address long-term outcomes.

AB - PURPOSE: We evaluated stricture-free survival and functional outcomes of buccal mucosa graft urethroplasty in patients with urethral stricture disease after radiotherapy.MATERIALS AND METHODS: We reviewed our urethroplasty database for patients with a radiotherapy history who underwent buccal mucosa graft urethroplasty between January 2009 and October 2013. We reviewed patient charts and the institutional, standardized, nonvalidated questionnaires administered to each patient postoperatively. Study end points included 1) the success rate, 2) continence status, 3) erectile function and 4) patient satisfaction postoperatively. Success was defined as stricture-free survival.RESULTS: Of 38 men included in the study prostate cancer was the most common indication for radiotherapy in 35 (92.1%). External beam radiotherapy was performed in 24 cases (64.9%), brachytherapy was done in 8 (21.6%) and a combination of the 2 treatments was performed in 6 (13.5%). Strictures were in the bulbar/bulbomembranous urethra and had a median length of 3.0 cm (range 1.0 to 8.0). The overall success rate was 71.1% at a median followup of 26.5 months (range 1.0 to 50.0). Median time to stricture recurrence was 17.0 months (range 3.0 to 44.0). De novo urinary incontinence was observed in 4 patients (10.5%). Erectile function remained mostly unchanged compared to preoperative status. Study limitations include the small sample size and the lack of validated questionnaires.CONCLUSIONS: At short-term to mid-term followup the success rate of ventral onlay buccal mucosa graft urethroplasty in patients with radiotherapy history seems acceptable. However, patients must be counseled about the increased risk of urinary incontinence. Longer followup is warranted to address long-term outcomes.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Disease-Free Survival

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Mouth Mucosa

KW - Prostatic Neoplasms

KW - Radiation Injuries

KW - Radiotherapy, Adjuvant

KW - Reconstructive Surgical Procedures

KW - Retrospective Studies

KW - Time Factors

KW - Treatment Outcome

KW - Urethra

KW - Urethral Stricture

KW - Urologic Surgical Procedures, Male

U2 - 10.1016/j.juro.2015.03.116

DO - 10.1016/j.juro.2015.03.116

M3 - SCORING: Journal article

C2 - 25846417

VL - 194

SP - 441

EP - 446

JO - J UROLOGY

JF - J UROLOGY

SN - 0022-5347

IS - 2

ER -