Outcomes of surgical bioprosthetic aortic valve replacement for aortic insufficiency
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Outcomes of surgical bioprosthetic aortic valve replacement for aortic insufficiency. / Danial, Pichoy; Girdauskas, Evaldas; Aissani, Anissa; Debauchez, Matthieu; Lebreton, Guillaume; Leprince, Pascal; Reichenspurner, Hermann; Petersen, Johannes; Lansac, Emmanuel.
In: ARCH CARDIOVASC DIS, Vol. 115, No. 11, 11.2022, p. 588-597.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Outcomes of surgical bioprosthetic aortic valve replacement for aortic insufficiency
AU - Danial, Pichoy
AU - Girdauskas, Evaldas
AU - Aissani, Anissa
AU - Debauchez, Matthieu
AU - Lebreton, Guillaume
AU - Leprince, Pascal
AU - Reichenspurner, Hermann
AU - Petersen, Johannes
AU - Lansac, Emmanuel
N1 - Copyright © 2022 Elsevier Masson SAS. All rights reserved.
PY - 2022/11
Y1 - 2022/11
N2 - BACKGROUND: Results and durability of aortic valve replacement in aortic stenosis are well known, but no study has focused on the results of aortic valve replacement in aortic insufficiency.AIM: The aim of this retrospective study was to describe our mid-term outcomes after aortic valve replacement for aortic insufficiency.METHODS: All consecutive adult patients who underwent bioprosthetic aortic valve replacement for aortic insufficiency at two European centres (in France and Germany) between May 2005 and December 2020 were analysed.RESULTS: During the study period, 289 patients were included. Mean age was 56.9±12.5 years. Overall operative mortality was 1.5%, and the 10-year survival estimate rate was 75.0%, which was significantly lower than in the age- and sex-matched general population, with a standardized mortality ratio of 2.88 (95% confidence interval 1.96-4.08; P<0001). Freedom from aortic valve-related death was 87.6%, and from aortic valve-related reoperation was 87.4%. No patient aged>60 years was reoperated on during follow-up. Freedom from severe structural valve deterioration at 10 years was 73.3%, and freedom from moderate structural valve deterioration at 10 years was 50.3%. Freedom from major adverse valve-related events at 10 years was 69.7%.CONCLUSIONS: Although bioprosthetic aortic valve replacement for aortic insufficiency shows good early results, 10-year mortality and major adverse valve-related event rates in young patients may be a concern, with a reduction in life expectancy compared with the general population.
AB - BACKGROUND: Results and durability of aortic valve replacement in aortic stenosis are well known, but no study has focused on the results of aortic valve replacement in aortic insufficiency.AIM: The aim of this retrospective study was to describe our mid-term outcomes after aortic valve replacement for aortic insufficiency.METHODS: All consecutive adult patients who underwent bioprosthetic aortic valve replacement for aortic insufficiency at two European centres (in France and Germany) between May 2005 and December 2020 were analysed.RESULTS: During the study period, 289 patients were included. Mean age was 56.9±12.5 years. Overall operative mortality was 1.5%, and the 10-year survival estimate rate was 75.0%, which was significantly lower than in the age- and sex-matched general population, with a standardized mortality ratio of 2.88 (95% confidence interval 1.96-4.08; P<0001). Freedom from aortic valve-related death was 87.6%, and from aortic valve-related reoperation was 87.4%. No patient aged>60 years was reoperated on during follow-up. Freedom from severe structural valve deterioration at 10 years was 73.3%, and freedom from moderate structural valve deterioration at 10 years was 50.3%. Freedom from major adverse valve-related events at 10 years was 69.7%.CONCLUSIONS: Although bioprosthetic aortic valve replacement for aortic insufficiency shows good early results, 10-year mortality and major adverse valve-related event rates in young patients may be a concern, with a reduction in life expectancy compared with the general population.
KW - Adult
KW - Humans
KW - Middle Aged
KW - Aged
KW - Aortic Valve/diagnostic imaging
KW - Retrospective Studies
KW - Heart Valve Prosthesis Implantation
KW - Postoperative Complications
KW - Bioprosthesis
KW - Heart Valve Prosthesis/adverse effects
KW - Aortic Valve Insufficiency/diagnostic imaging
KW - Aortic Valve Stenosis/surgery
KW - Reoperation
U2 - 10.1016/j.acvd.2022.08.001
DO - 10.1016/j.acvd.2022.08.001
M3 - SCORING: Journal article
C2 - 36272966
VL - 115
SP - 588
EP - 597
JO - ARCH CARDIOVASC DIS
JF - ARCH CARDIOVASC DIS
SN - 1875-2136
IS - 11
ER -
