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Outcomes of robotic-assisted versus open radical cystectomy in a large-scale, contemporary cohort of bladder cancer patients

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Outcomes of robotic-assisted versus open radical cystectomy in a large-scale, contemporary cohort of bladder cancer patients. / Hoeh, Benedikt; Flammia, Rocco S; Hohenhorst, Lukas; Sorce, Gabriele; Chierigo, Francesco; Panunzio, Andrea; Tian, Zhe; Saad, Fred; Gallucci, Michele; Briganti, Alberto; Terrone, Carlo; Shariat, Shahrokh F; Graefen, Markus; Tilki, Derya; Antonelli, Alessandro; Kluth, Luis A; Becker, Andreas; Chun, Felix K H; Karakiewicz, Pierre I.

In: J SURG ONCOL, Vol. 126, No. 4, 09.2022, p. 830-837.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hoeh, B, Flammia, RS, Hohenhorst, L, Sorce, G, Chierigo, F, Panunzio, A, Tian, Z, Saad, F, Gallucci, M, Briganti, A, Terrone, C, Shariat, SF, Graefen, M, Tilki, D, Antonelli, A, Kluth, LA, Becker, A, Chun, FKH & Karakiewicz, PI 2022, 'Outcomes of robotic-assisted versus open radical cystectomy in a large-scale, contemporary cohort of bladder cancer patients', J SURG ONCOL, vol. 126, no. 4, pp. 830-837. https://doi.org/10.1002/jso.26973

APA

Hoeh, B., Flammia, R. S., Hohenhorst, L., Sorce, G., Chierigo, F., Panunzio, A., Tian, Z., Saad, F., Gallucci, M., Briganti, A., Terrone, C., Shariat, S. F., Graefen, M., Tilki, D., Antonelli, A., Kluth, L. A., Becker, A., Chun, F. K. H., & Karakiewicz, P. I. (2022). Outcomes of robotic-assisted versus open radical cystectomy in a large-scale, contemporary cohort of bladder cancer patients. J SURG ONCOL, 126(4), 830-837. https://doi.org/10.1002/jso.26973

Vancouver

Hoeh B, Flammia RS, Hohenhorst L, Sorce G, Chierigo F, Panunzio A et al. Outcomes of robotic-assisted versus open radical cystectomy in a large-scale, contemporary cohort of bladder cancer patients. J SURG ONCOL. 2022 Sep;126(4):830-837. https://doi.org/10.1002/jso.26973

Bibtex

@article{98e5d5083e36402fa597087466a98234,
title = "Outcomes of robotic-assisted versus open radical cystectomy in a large-scale, contemporary cohort of bladder cancer patients",
abstract = "BACKGROUND AND OBJECTIVES: To test for differences in perioperative outcomes and total hospital costs (THC) in nonmetastatic bladder cancer patients undergoing open (ORC) versus robotic-assisted radical cystectomy (RARC).METHODS: We relied on the National Inpatient Sample database (2016-2019). Statistics consisted of trend analyses, multivariable logistic, Poisson, and linear regression models.RESULTS: Of 5280 patients, 1876 (36%) versus 3200 (60%) underwent RARC versus ORC. RARC increased from 32% to 41% (estimated annual percentage change [EAPC]: + 8.6%; p = 0.02). Rates of transfusion (8% vs. 16%), intraoperative (2% vs. 3%), wound (6% vs. 10%), and pulmonary (6% vs. 10%) complications were lower in RARC patients (all p < 0.05). Moreover, median length of stay (LOS) was shorter in RARC (6 vs. 7days; p < 0.001). Conversely, median THC (31,486 vs. 27,162$; p < 0.001) were higher in RARC. Multivariable logistic regression-derived odds ratios addressing transfusion (0.49), intraoperative (0.53), wound (0.68), and pulmonary (0.71) complications favored RARC (all p < 0.01). In multivariable Poisson and linear regression models, RARC was associated with shorter LOS (Rate ratio:0.86; p < 0.001), yet higher THC (Coef.:5,859$; p < 0.001). RARC in-hospital mortality was lower (1% vs. 2%; p = 0.04).CONCLUSIONS: RARC complications, LOS, and mortality appear more favorable than ORC, but result in higher THC. The favorable RARC profile contributes to its increasing popularity throughout the United States.",
keywords = "Humans, Cystectomy/adverse effects, Postoperative Complications/etiology, Robotic Surgical Procedures, Treatment Outcome, Urinary Bladder, Urinary Bladder Neoplasms",
author = "Benedikt Hoeh and Flammia, {Rocco S} and Lukas Hohenhorst and Gabriele Sorce and Francesco Chierigo and Andrea Panunzio and Zhe Tian and Fred Saad and Michele Gallucci and Alberto Briganti and Carlo Terrone and Shariat, {Shahrokh F} and Markus Graefen and Derya Tilki and Alessandro Antonelli and Kluth, {Luis A} and Andreas Becker and Chun, {Felix K H} and Karakiewicz, {Pierre I}",
note = "{\textcopyright} 2022 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.",
year = "2022",
month = sep,
doi = "10.1002/jso.26973",
language = "English",
volume = "126",
pages = "830--837",
journal = "J SURG ONCOL",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Outcomes of robotic-assisted versus open radical cystectomy in a large-scale, contemporary cohort of bladder cancer patients

AU - Hoeh, Benedikt

AU - Flammia, Rocco S

AU - Hohenhorst, Lukas

AU - Sorce, Gabriele

AU - Chierigo, Francesco

AU - Panunzio, Andrea

AU - Tian, Zhe

AU - Saad, Fred

AU - Gallucci, Michele

AU - Briganti, Alberto

AU - Terrone, Carlo

AU - Shariat, Shahrokh F

AU - Graefen, Markus

AU - Tilki, Derya

AU - Antonelli, Alessandro

AU - Kluth, Luis A

AU - Becker, Andreas

AU - Chun, Felix K H

AU - Karakiewicz, Pierre I

N1 - © 2022 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.

PY - 2022/9

Y1 - 2022/9

N2 - BACKGROUND AND OBJECTIVES: To test for differences in perioperative outcomes and total hospital costs (THC) in nonmetastatic bladder cancer patients undergoing open (ORC) versus robotic-assisted radical cystectomy (RARC).METHODS: We relied on the National Inpatient Sample database (2016-2019). Statistics consisted of trend analyses, multivariable logistic, Poisson, and linear regression models.RESULTS: Of 5280 patients, 1876 (36%) versus 3200 (60%) underwent RARC versus ORC. RARC increased from 32% to 41% (estimated annual percentage change [EAPC]: + 8.6%; p = 0.02). Rates of transfusion (8% vs. 16%), intraoperative (2% vs. 3%), wound (6% vs. 10%), and pulmonary (6% vs. 10%) complications were lower in RARC patients (all p < 0.05). Moreover, median length of stay (LOS) was shorter in RARC (6 vs. 7days; p < 0.001). Conversely, median THC (31,486 vs. 27,162$; p < 0.001) were higher in RARC. Multivariable logistic regression-derived odds ratios addressing transfusion (0.49), intraoperative (0.53), wound (0.68), and pulmonary (0.71) complications favored RARC (all p < 0.01). In multivariable Poisson and linear regression models, RARC was associated with shorter LOS (Rate ratio:0.86; p < 0.001), yet higher THC (Coef.:5,859$; p < 0.001). RARC in-hospital mortality was lower (1% vs. 2%; p = 0.04).CONCLUSIONS: RARC complications, LOS, and mortality appear more favorable than ORC, but result in higher THC. The favorable RARC profile contributes to its increasing popularity throughout the United States.

AB - BACKGROUND AND OBJECTIVES: To test for differences in perioperative outcomes and total hospital costs (THC) in nonmetastatic bladder cancer patients undergoing open (ORC) versus robotic-assisted radical cystectomy (RARC).METHODS: We relied on the National Inpatient Sample database (2016-2019). Statistics consisted of trend analyses, multivariable logistic, Poisson, and linear regression models.RESULTS: Of 5280 patients, 1876 (36%) versus 3200 (60%) underwent RARC versus ORC. RARC increased from 32% to 41% (estimated annual percentage change [EAPC]: + 8.6%; p = 0.02). Rates of transfusion (8% vs. 16%), intraoperative (2% vs. 3%), wound (6% vs. 10%), and pulmonary (6% vs. 10%) complications were lower in RARC patients (all p < 0.05). Moreover, median length of stay (LOS) was shorter in RARC (6 vs. 7days; p < 0.001). Conversely, median THC (31,486 vs. 27,162$; p < 0.001) were higher in RARC. Multivariable logistic regression-derived odds ratios addressing transfusion (0.49), intraoperative (0.53), wound (0.68), and pulmonary (0.71) complications favored RARC (all p < 0.01). In multivariable Poisson and linear regression models, RARC was associated with shorter LOS (Rate ratio:0.86; p < 0.001), yet higher THC (Coef.:5,859$; p < 0.001). RARC in-hospital mortality was lower (1% vs. 2%; p = 0.04).CONCLUSIONS: RARC complications, LOS, and mortality appear more favorable than ORC, but result in higher THC. The favorable RARC profile contributes to its increasing popularity throughout the United States.

KW - Humans

KW - Cystectomy/adverse effects

KW - Postoperative Complications/etiology

KW - Robotic Surgical Procedures

KW - Treatment Outcome

KW - Urinary Bladder

KW - Urinary Bladder Neoplasms

U2 - 10.1002/jso.26973

DO - 10.1002/jso.26973

M3 - SCORING: Journal article

C2 - 35661361

VL - 126

SP - 830

EP - 837

JO - J SURG ONCOL

JF - J SURG ONCOL

SN - 0022-4790

IS - 4

ER -