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Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck

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Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck. / Jansen, Florian; Betz, Christian Stephan; Belau, Matthias; Matnjani, Gesa; Clauditz, Till Sebastian; Rico, Sebastian Dwertmann; Stölzel, Katharina; Möckelmann, Nikolaus; Böttcher, Arne.

In: EUR ARCH OTO-RHINO-L, Vol. 280, No. 8, 08.2023, p. 3843-3853.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jansen, F, Betz, CS, Belau, M, Matnjani, G, Clauditz, TS, Rico, SD, Stölzel, K, Möckelmann, N & Böttcher, A 2023, 'Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck', EUR ARCH OTO-RHINO-L, vol. 280, no. 8, pp. 3843-3853. https://doi.org/10.1007/s00405-023-07972-4

APA

Jansen, F., Betz, C. S., Belau, M., Matnjani, G., Clauditz, T. S., Rico, S. D., Stölzel, K., Möckelmann, N., & Böttcher, A. (2023). Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck. EUR ARCH OTO-RHINO-L, 280(8), 3843-3853. https://doi.org/10.1007/s00405-023-07972-4

Vancouver

Jansen F, Betz CS, Belau M, Matnjani G, Clauditz TS, Rico SD et al. Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck. EUR ARCH OTO-RHINO-L. 2023 Aug;280(8):3843-3853. https://doi.org/10.1007/s00405-023-07972-4

Bibtex

@article{4bc7d0d085074fd193f2c7b3750dd998,
title = "Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck",
abstract = "PURPOSE: There are no consensus guidelines regarding the postoperative treatment of the contralateral pathologically node-negative neck in oropharyngeal squamous cell carcinoma. This study aimed to determine if omission of postoperative irradiation of the contralateral pathologically node-negative neck affects oncological outcomes.METHODS: We retrospectively identified 84 patients with primary surgical treatment including bilateral neck dissection and postoperative (chemo-)radiotherapy (PO(C)RT). Survival was analyzed using the log-rank test and the Kaplan-Meier method.RESULTS: Patients showed no decrease in tumor-free, cause-specific (CSS), or overall survival (OS) when PO(C)RT of the contralateral pathologically node-negative neck was omitted. Increased OS was found in patients with unilateral PO(C)RT and especially an increased OS and CSS was found in unilateral PO(C)RT and in tumors arising from lymphoepithelial tissue.CONCLUSIONS: Omitting the contralateral pathologically node-negative neck appears to be safe in terms of survival and our retrospective study advocates further prospective randomized control de-escalation trials.",
author = "Florian Jansen and Betz, {Christian Stephan} and Matthias Belau and Gesa Matnjani and Clauditz, {Till Sebastian} and Rico, {Sebastian Dwertmann} and Katharina St{\"o}lzel and Nikolaus M{\"o}ckelmann and Arne B{\"o}ttcher",
year = "2023",
month = aug,
doi = "10.1007/s00405-023-07972-4",
language = "English",
volume = "280",
pages = "3843--3853",
journal = "EUR ARCH OTO-RHINO-L",
issn = "0937-4477",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck

AU - Jansen, Florian

AU - Betz, Christian Stephan

AU - Belau, Matthias

AU - Matnjani, Gesa

AU - Clauditz, Till Sebastian

AU - Rico, Sebastian Dwertmann

AU - Stölzel, Katharina

AU - Möckelmann, Nikolaus

AU - Böttcher, Arne

PY - 2023/8

Y1 - 2023/8

N2 - PURPOSE: There are no consensus guidelines regarding the postoperative treatment of the contralateral pathologically node-negative neck in oropharyngeal squamous cell carcinoma. This study aimed to determine if omission of postoperative irradiation of the contralateral pathologically node-negative neck affects oncological outcomes.METHODS: We retrospectively identified 84 patients with primary surgical treatment including bilateral neck dissection and postoperative (chemo-)radiotherapy (PO(C)RT). Survival was analyzed using the log-rank test and the Kaplan-Meier method.RESULTS: Patients showed no decrease in tumor-free, cause-specific (CSS), or overall survival (OS) when PO(C)RT of the contralateral pathologically node-negative neck was omitted. Increased OS was found in patients with unilateral PO(C)RT and especially an increased OS and CSS was found in unilateral PO(C)RT and in tumors arising from lymphoepithelial tissue.CONCLUSIONS: Omitting the contralateral pathologically node-negative neck appears to be safe in terms of survival and our retrospective study advocates further prospective randomized control de-escalation trials.

AB - PURPOSE: There are no consensus guidelines regarding the postoperative treatment of the contralateral pathologically node-negative neck in oropharyngeal squamous cell carcinoma. This study aimed to determine if omission of postoperative irradiation of the contralateral pathologically node-negative neck affects oncological outcomes.METHODS: We retrospectively identified 84 patients with primary surgical treatment including bilateral neck dissection and postoperative (chemo-)radiotherapy (PO(C)RT). Survival was analyzed using the log-rank test and the Kaplan-Meier method.RESULTS: Patients showed no decrease in tumor-free, cause-specific (CSS), or overall survival (OS) when PO(C)RT of the contralateral pathologically node-negative neck was omitted. Increased OS was found in patients with unilateral PO(C)RT and especially an increased OS and CSS was found in unilateral PO(C)RT and in tumors arising from lymphoepithelial tissue.CONCLUSIONS: Omitting the contralateral pathologically node-negative neck appears to be safe in terms of survival and our retrospective study advocates further prospective randomized control de-escalation trials.

U2 - 10.1007/s00405-023-07972-4

DO - 10.1007/s00405-023-07972-4

M3 - SCORING: Journal article

C2 - 37133497

VL - 280

SP - 3843

EP - 3853

JO - EUR ARCH OTO-RHINO-L

JF - EUR ARCH OTO-RHINO-L

SN - 0937-4477

IS - 8

ER -